Browsing Neuroscience by Title
Now showing items 84-103 of 117
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Real-time tracking of olfactory information, and correlating behavior with odor plume-encounters in an olfactory-guided navigation task: On why my ethanol plumes brought all the mice to the yard
Understanding the neural underpinnings of sensory-guided decision-making has been one of the central pursuits of neuroscience. Olfaction is one key sensory modality that ensures the survival of a species by guiding essential ... -
Regulation of mitochondrial and nonmitochondrial protein turnover by the PINK1-Parkin pathway
(2013-07-23)The accumulation of damaged mitochondria has been proposed as a key factor in aging and in the pathogenesis of many common age-related diseases, including Parkinson disease (PD). Recently, <italic>in vitro</italic> studies ... -
Remembering What We've Seen: The Hippocampus and Relational Memory
Relational memory is the ability to remember arbitrary associations between objects or events. These memories include things related by location, order, and context. Lesions of the medial temporal lobe (MTL) cause severe ... -
Representation of color in the human retina
Preceding the development of modern biological techniques, psychophysical experimentation and careful reasoning alone yielded an accurate account of human color perception predicated upon three opponent processes: blue ... -
Role of perineuronal nets in the cerebellar nuclei: Insights from histology and behavior
(2013-11-14)Perineuronal nets are structures in the extracellular matrix that previous work implicates in either inhibiting synaptic plasticity or protecting neurons from oxidative damage. We use histological techniques to explore the ... -
The role of the corticothalamic projection in the primate motor thalamus
(2007)The work in this dissertation focuses on identifying corticothalamic neurons and characterizing the signals carried along this pathway in the primate motor system. All experiments were carried out in awake primates performing ... -
Role of the Ventral Striatal Pathways in Reinforcement Learning: Chemogenetic Modulation During the Incubation of Craving
Cocaine addiction is a major public health problem with high rates of relapse. The incubation of cocaine craving, characterized by an increase in cue-induced cocaine seeking behavior after abstinence, is thought to play a ... -
Roles of GABAergic interneurons in calcium waves of the developing neocortex
Between early periods of brain development when genetic programs structure the basic features of the brain, and later periods when sensory-driven electrical activity refines neuronal connections, spontaneous activity ... -
Serotonin and Song: neuronal and behavioral effects in the zebra finch
(2013-04-17)Serotonin (5-HT) is a neuromodulator important in a vast array of neurological processes, including sensory and motor processing. Dysfunction of the 5-HT system is associated with depression and other clinically important ... -
Simulating the Effects of Neural Pathology on Cochlear Implant Responses
Cochlear implants (CIs) provide a strategy for treating severe to profound sensorineural hearing loss (SNHL) that cannot be adequately managed by amplifying acoustic signals. There is considerable variability of CI ... -
Sleep is important: How circadian-timed trauma keeps mice up at day and the societal implications that keep me up at night
This thesis centers on the vital process of sleep and its profound influences on various dimensions of human life, with focus on connections between sleep and aspects of well-being. This thesis adopts a multidisciplinary ... -
Sleeping on the Job: How studying sleep and circadian rhythm disturbances in a mouse model of Dravet syndrome kept me up at night
Epilepsies are among the most common neurological disorders in the world, and sleep disturbances are highly comorbid with many forms of epilepsy. Dravet syndrome (DS) is a severe form of childhood onset epilepsy caused by ... -
Somatic Size and Cav1.3 Channel Expression in Vulnerable and Resistant Motoneurons of the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
(2013-11-14)The loss of motoneurons is an undisputed feature of amyotrophic lateral sclerosis (ALS) and its animal models (SOD1 mutant mice), but how the disease affects the size and shape of motoneurons prior to their degeneration ... -
Spatial organization of long-range inhibition in binaural hearing
(2013-02-25)We are able to follow our friend's voice as she calls across a crowded plaza or whispers in a darkened theater. Amazingly our sense of hearing can identify and localize sounds ranging eight orders of magnitude in loudness. ... -
Specificity in Glia-Neuron Interactions
Glia are important regulators of nervous system development and function. In both central and peripheral nervous systems, glia modulate neuron structure and function through a vast array of molecular mechanisms. One remaining ... -
Spontaneous and Evoked Calcium Waves Reveal State Dependent Functional Connectivity Changes in the Developing and Adult Mouse Cortex
During development, and into adulthood, the mouse cortex exhibits propagating waves that span the entire cortex. These waves are typically observed as a pattern whereby local cortical activity is followed by activation in ... -
Spontaneous and task-related changes in resting state connectivity
Resting state brain connectivity is thought to represent ongoing cognitive processes, including memory consolidation, that occur outside of the context of a specific task. While the existence of synchronous brain activity ... -
Stage-dependent regulation of intracellular calcium by spontaneous activity in developing brainstem
(2013-11-14)Spontaneous activity supports developmental processes in many brain regions during embryogenesis, and the spatial extent and frequency of the spontaneous activity are tightly regulated by stage. In the developing mouse ... -
Stimulating retinal neurogenesis from Müller glia
(2014-02-24)Damage to the retina, through disease or injury, can lead to the permanent loss of neurons and ultimately loss of vision. Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from Müller ... -
Striatal 5-HT6 receptors: Roles in cocaine reinforcement and neuronal primary cilia
Serotonin (5-HT) is neurotransmitter that modulates a range of emotional behaviors and is involved in mediating behaviors related to reinforcement learning. Disturbances of the 5-HT system are implicated in psychiatric ...