Browsing Neuroscience by Title
Now showing items 92-111 of 117
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Serotonin and Song: neuronal and behavioral effects in the zebra finch
(2013-04-17)Serotonin (5-HT) is a neuromodulator important in a vast array of neurological processes, including sensory and motor processing. Dysfunction of the 5-HT system is associated with depression and other clinically important ... -
Simulating the Effects of Neural Pathology on Cochlear Implant Responses
Cochlear implants (CIs) provide a strategy for treating severe to profound sensorineural hearing loss (SNHL) that cannot be adequately managed by amplifying acoustic signals. There is considerable variability of CI ... -
Sleep is important: How circadian-timed trauma keeps mice up at day and the societal implications that keep me up at night
This thesis centers on the vital process of sleep and its profound influences on various dimensions of human life, with focus on connections between sleep and aspects of well-being. This thesis adopts a multidisciplinary ... -
Sleeping on the Job: How studying sleep and circadian rhythm disturbances in a mouse model of Dravet syndrome kept me up at night
Epilepsies are among the most common neurological disorders in the world, and sleep disturbances are highly comorbid with many forms of epilepsy. Dravet syndrome (DS) is a severe form of childhood onset epilepsy caused by ... -
Somatic Size and Cav1.3 Channel Expression in Vulnerable and Resistant Motoneurons of the SOD1 Mouse Model of Amyotrophic Lateral Sclerosis
(2013-11-14)The loss of motoneurons is an undisputed feature of amyotrophic lateral sclerosis (ALS) and its animal models (SOD1 mutant mice), but how the disease affects the size and shape of motoneurons prior to their degeneration ... -
Spatial organization of long-range inhibition in binaural hearing
(2013-02-25)We are able to follow our friend's voice as she calls across a crowded plaza or whispers in a darkened theater. Amazingly our sense of hearing can identify and localize sounds ranging eight orders of magnitude in loudness. ... -
Specificity in Glia-Neuron Interactions
Glia are important regulators of nervous system development and function. In both central and peripheral nervous systems, glia modulate neuron structure and function through a vast array of molecular mechanisms. One remaining ... -
Spontaneous and Evoked Calcium Waves Reveal State Dependent Functional Connectivity Changes in the Developing and Adult Mouse Cortex
During development, and into adulthood, the mouse cortex exhibits propagating waves that span the entire cortex. These waves are typically observed as a pattern whereby local cortical activity is followed by activation in ... -
Spontaneous and task-related changes in resting state connectivity
Resting state brain connectivity is thought to represent ongoing cognitive processes, including memory consolidation, that occur outside of the context of a specific task. While the existence of synchronous brain activity ... -
Stage-dependent regulation of intracellular calcium by spontaneous activity in developing brainstem
(2013-11-14)Spontaneous activity supports developmental processes in many brain regions during embryogenesis, and the spatial extent and frequency of the spontaneous activity are tightly regulated by stage. In the developing mouse ... -
Stimulating retinal neurogenesis from Müller glia
(2014-02-24)Damage to the retina, through disease or injury, can lead to the permanent loss of neurons and ultimately loss of vision. Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from Müller ... -
Striatal 5-HT6 receptors: Roles in cocaine reinforcement and neuronal primary cilia
Serotonin (5-HT) is neurotransmitter that modulates a range of emotional behaviors and is involved in mediating behaviors related to reinforcement learning. Disturbances of the 5-HT system are implicated in psychiatric ... -
Targeted therapies for medulloblastoma: understanding the mechanisms of drug resistance and exploring new peptide-based therapeutics
(2013-07-23)Medulloblastoma, the most common malignant pediatric brain tumor, is currently treated with nonspecific cytotoxic therapies including surgery, radiation, and aggressive chemotherapy. Despite enhancements in treatment ... -
The estimation and explanation of tuning curves in intermediate visual areas
In sensory neuroscience, the characterization of neuronal tuning curves is the de facto method for understanding the bulk of cortical sensory representation. In this thesis, I make two primary contributions to this approach. ... -
The Influence of Environmental Manipulations on Decision-Making and Dopamine Transmission
The process of educating responses/decisions and controlling our environment can be seen as true liberty. The environment and organisms within it have a bidirectional relationship: the environment affects our internal state ... -
The ins of the striatum: Utilizing chemogenetics to define the contribution of cortical and thalamic afferents during addiction behaviors
Addiction is a chronic neuropsychiatric disorder accompanied by high rates of recidivism that lacks effect treatment, part of which may be due to an incomplete understanding of the brain circuits mediating addiction. ... -
THE ROLE OF HYPOCRETIN IN POST-TRAUMATIC BRAIN INJURY SLEEP-WAKE DISTURBANCE
Traumatic brain injury (TBI) is a major cause of disability, affecting millions of individuals in the United States alone. Disorders of sleep and wakefulness occur in over half of people who sustain a TBI. Sleep-wake ... -
The role of macaque V1 neurons in spatiochromatic processing and behavior
Vision is critical for survival. We can easily identify objects, guide actions, and avoid collisions if our eyes are open but these abilities are severely impaired if our eyes are closed. This tremendous feat of vision ... -
The role of muscarinic cholinergic signaling in cost-benefit decision making
Animals regularly face decisions that affect both their immediate success and long term survival. Such decisions typically involve some form of cost-benefit analysis and engage a number of high level cognitive processes, ... -
The role of the FEFsem in smooth pursuit: Insights from varying retinal input
Primates are exceptionally adept at tracking moving objects with their eyes, providing high-acuity vision throughout the duration of tracking. This behavior, called smooth pursuit, relies on incoming visual signals being ...