Browsing Neuroscience by Title
Now showing items 1-20 of 117
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5-HT1B Autoreceptors: Molecular Mechanisms and Behavioral Implications
The serotonergic system is important in modulating a range of emotional behaviors, and disturbances of this system are implicated in psychiatric conditions such as post-traumatic stress disorder, depression, and anxiety. ... -
5-HT2A-mediated signaling regulates spontaneous waves and 5-HT cell number in the embryonic mouse hindbrain
The mouse hindbrain experiences waves of spontaneous depolarizations early in the development of the nervous system. Hindbrain cells along the ventral midline of the neural tube participate in waves for three days with ... -
A diverse network of pericoerulear neurons controls arousal
As the primary source of norepinephrine in the brain, the locus coeruleus (LC) plays a key role in regulating arousal. The tuning of LC noradrenergic neuron (LC-NE) activity by distant and local neuromodulatory networks ... -
A multi-species model for selective pruritus via the direct activation of TRPA1
Pruritus, or itch, is an unpleasant cutaneous sensation that elicits a desire to scratch. In mammals, this sensation occurs when itch-inducing stimuli activate pruritic receptor proteins on somatosensory neurons, which ... -
A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
Voltage-gated sodium channels (Navs) are responsible for the upstroke of action potentials in electrically excitable cells. Transmission of nociceptive information from the body periphery to the central nervous system is ... -
Acute regulation of synaptic NMDA receptor content in hippocampal neurons
Hippocampal-dependent learning, which is required for forming fact-based, declarative memories, involves changing the physical and functional characteristics of connections between neurons, called synapses. This process ... -
Auditory Perception and the Electrode-Neuron Interface in Children and Adults with Cochlear Implants
Cochlear implants (CIs) restore auditory perception to individuals with severe to profound hearing loss, yet identification of speech sounds remains limited due to degraded or distorted representations of frequency ... -
Biophysical Population Models of the Auditory Nerve
Biophysical models of the electrically stimulated auditory nerve are a powerful tool to simulate the neural response to cochlear implant stimulation. We review the history and development of these computational models, ... -
Brain-Based Individual Difference Measures of Reading Skill in Deaf and Hearing Adults
A majority of deaf students leave high school reading at or below a fourth grade level, but some deaf individuals do become highly proficient readers. There is disagreement about the causes of this reading difficulty, and ... -
Central and Peripheral Nervous System Sequelae Following Blast Exposures: A Multi-Organ System Analysis of a Complex Full-Body Injury
Many injuries have the capacity to impact the entire body, even if the inciting incident was something seemingly localized to one body part, like a concussion, it can affect the whole-body. Injuries sustained following ... -
Cerebellar degeneration and prevention of symptom progression in a mouse model of spinocerebellar ataxia type 7
(2013-02-25)Spinocerebellar ataxia type 7 (SCA7) is a dominantly inherited disorder characterized by progressive cerebellar, brainstem, and retinal degeneration. SCA7 is caused by a CAG/polyglutamine (polyQ) repeat expansion in the ... -
CGRP neurons and the neural circuitry underlying conditioned taste aversion
Food aversions develop when the taste of a novel food is associated with sickness, which often occurs after food poisoning or chemotherapy treatment. This phenomenon, known as conditioned taste aversion (CTA), protects ... -
Characterization of galanin in the murine brain
(2001)The neuropeptide galanin has been implicated in a many central nervous system functions. These range from fundamental processes, such the ability to successfully breed and regulate metabolism, to higher order functions ... -
Characterizing the mechanisms of kappa opioid receptor signaling within mesolimbic dopamine circuitry
Our bodies use neuropeptides to modulate our behavioral and emotional responding to stimuli, like stress. These small proteins act on receptors in our brain cells, or neurons, to promote certain behaviors and make long-lasting ... -
Characterizing the role of accumbens medium spiny neurons in vulnerability to heroin addiction
Opioid addiction is a chronic, relapsing disorder that arises from dysregulation of the neural circuits responsible for reward processing, associative learning, and decision making, and is conceptualized as a three-stage, ... -
Characterizing the role of cortical neuronal subtypes and drug intake pattern in cocaine addiction
Drug addiction is a complex neuropsychiatric disorder that takes a great emotional and financial toll on those who suffer from it as well as society as a whole. Psychologically, drugs of abuse produce an unusual mix of ... -
Characterizing the spatial and temporal frequency tuning properties in mouse visual cortex with calcium imaging
In the neocortex, neurons with similar functional properties are clustered together. While incompletely understood, this feature of cortical organization is conserved across a variety of species and sensory systems. In the ... -
Cholinergic signaling is essential for hydrogen sulfide responses in Caenorhabditis elegans
Hydrogen sulfide, H2S, is one of three endogenously produced gaseous molecules that can act in cellular signaling. In the brain, H2S has proposed roles in modulating long-term potentiation, nociception, and neuroprotection. ... -
Chromatic detection from cone photoreceptors to individual V1 neurons to behavior in macaque monkeys
(2013-11-14)Vision is the culmination of countless biophysical events from the initial stages of sensory transduction to conscious perception. Despite the complexity of this process, our brains encode the visual world effortlessly in ... -
Chronic Monitoring and Longitudinal Efficacy of Neuromodulation for Neurological Movement Disorders
Modern chronic stimulation therapies with sensing capability offer a unique opportinuty to effectively manage the symptoms of a disease while also providing an understanding of the progression of neurological disorders. I ...