Browsing Bioengineering by Title
Now showing items 52-71 of 356
-
Computational design of interleukin-2 mimetics
Interleukin-2 is a cytokine that plays a central role in immune system homeostasis, exerting paradoxical immunostimulatory and immunoregulatory effects based on its interactions with various receptor subunits differentially ... -
Computational Design of Proteins and Peptides Harboring Binding Interfaces
Computational protein design has advanced rapidly in recent years. Starting from designing for novel protein and peptide structures, the focus of the field has shifted from designing for folds to designing for functions. ... -
Computational Design of Small Molecule Binding Proteins
Protein design is still in its infancy, yet there have been many impressive examples of success in designing proteins to fold into a predictable structure, to catalyse enzymatic reactions, or to bind a specific protein, ... -
Computational Modeling of Optical Projection Tomographic Microscopy
(2013-07-25)Lung cancer is the leading cause of cancer related deaths worldwide with 1.37 millions deaths per year. In 2011, Computed Tomography became the first method approved for early detection, however it is hindered by safety ... -
Constraint of Motivation and Value by Limbic Opioidergic Systems
The mesolimbic pathway connects the ventral tegmental area (VTA) to the nucleus accumbens (NAc) and has been extensively studied for its role in processing rewards, mediating reinforcement learning and promoting motivated ... -
Constructing functional graphs and recurrent neural network models of neural dynamics using calcium imaging data in Python
Leveraging the power of computational analyses and modeling could assist with the study of neural dynamics. Complex analyses like graph theory could enable biomarker discovery in psychiatric illnesses, and recurrent neural ... -
Constructing Hybrid Cytokine Receptors to Amplify CAR T Cell Anti-Tumor Potency
Chimeric antigen receptors (CARs) have achieved remarkable therapeutic efficacy against cancer by linking natural circuits of T cell activation to the recognition of tumor-associated antigens, but optimal anti-tumor responses ... -
Contractile Properties of Striated Muscle in Development and In Disease
In utero development is a key time for muscle formation, and muscle-related birth defects are sometimes linked to mutations in muscle contractile proteins expressed in utero. Even in heart disease, the development of the ... -
Control of protein activities by conjugation of stimuli-responsive polymers to proteins
(2000)Streptavidin binds biotin with an extraordinary affinity (Ka = 1013--15 M-1). This unique property has found widespread applications in biotechnology fields. However, its application in affinity separation is limited because ... -
Control of stemness in CD8 T cell differentiation
T cell stemness enables continual generation of cytotoxic effector cells from a self-renewing pool of multipotent progenitors. After an acute infection, memory T cells persist for years in a quiescent state and upon ... -
Controlling apoptosis with computationally designed inhibitors targeting pro-survival and pro-apoptosis BCL2 family members
BCL2 family proteins regulate apoptosis and thus play a critical role in tissue homeostasis and development in healthy cells. A number of pathologies exploit the BCL2 family to promote artificially prolonged life or premature ... -
Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
This dissertation discusses the application of light-induced stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter ... -
Controlling Enzyme Expression Dynamics to Improve Production from Engineered Biosynthetic Pathways
Metabolic engineering promises to reduce our reliance on non-renewable chemical synthesis methods by harnessing microbial metabolisms to convert simple renewable resources, such as sugars, into useful chemicals, such as ... -
Converting Vertical Vibration of a Texture Ratchet into Horizontal Drop Motion
(2013-07-23)A texture ratchet is an anisotropic, periodic, microstructured surface that propels drops when vibrated with a sinusoidal signal at certain frequencies and amplitudes. For each input frequency near the resonant frequency ... -
Correlation-Based Contraction Tracking of Cardiomyocyte Monolayers
Cardiac tissue engineering has made great strides in combating cardiovascular disease in modern society utilizing cardiac regenerative medicine as well as in vitro disease modeling. Stem cell-derived cardiomyocytes are a ... -
Cross-linked hydrogels for the delivery of growth factors in tissue engineering
(2003)The goal of tissue engineering is the regeneration or replacement of failed or damaged tissues with viable and functional tissues that integrate with the host system. However, this vision has not yet been fully realized. ... -
De novo design of protein binders as functional therapeutics
De novo design of protein binding proteins (minibinders) with target structure information alone remains a grand challenge. A general computational design framework includes (1) generation of binder backbones, (2) sequence ... -
Decoding Coordinated Hand Movement in Human Primary Motor Cortex Using High Resolution Electrocorticography
(2014-02-24)Electrophysiology studies of the brain allow us to study the dynamics of the cortex as subjects perform tasks and experiment. Of particular interest in human studies is the activity that occurs in motor related areas of ... -
Deep Learning and Cloud Science for the Engineering of Biological Molecules and Systems
Solving many of the greatest challenges facing our industrial landscape and therapeutic de- velopment will require innovations in both computational and experimental biology alike. Deep learning has demonstrated it capacity ... -
Defining murine cardiac fibroblast cellular states via fibroblast-vascular crosstalk and extracellular matrix remodeling
The overarching focus of this thesis is to gain insight into novel categories of cardiac fibroblast cellular state by probing the biological underpinnings of how structure dictates function. Cardiac fibroblasts are responsible ...