Browsing Bioengineering by Subject "Biomedical engineering"
Now showing items 21-40 of 166
-
Computational Design of Small Molecule Binding Proteins
Protein design is still in its infancy, yet there have been many impressive examples of success in designing proteins to fold into a predictable structure, to catalyse enzymatic reactions, or to bind a specific protein, ... -
Computational Modeling of Optical Projection Tomographic Microscopy
(2013-07-25)Lung cancer is the leading cause of cancer related deaths worldwide with 1.37 millions deaths per year. In 2011, Computed Tomography became the first method approved for early detection, however it is hindered by safety ... -
Controlling apoptosis with computationally designed inhibitors targeting pro-survival and pro-apoptosis BCL2 family members
BCL2 family proteins regulate apoptosis and thus play a critical role in tissue homeostasis and development in healthy cells. A number of pathologies exploit the BCL2 family to promote artificially prolonged life or premature ... -
Controlling Arrhythmias Using Optogenetic Actuators in Computational Simulations
This dissertation discusses the application of light-induced stimulation (optogenetics) in computational models of heart cells (cardiomyocytes), cardiac tissues, and heart chambers to control arrhythmia development. Chapter ... -
Converting Vertical Vibration of a Texture Ratchet into Horizontal Drop Motion
(2013-07-23)A texture ratchet is an anisotropic, periodic, microstructured surface that propels drops when vibrated with a sinusoidal signal at certain frequencies and amplitudes. For each input frequency near the resonant frequency ... -
Correlation-Based Contraction Tracking of Cardiomyocyte Monolayers
Cardiac tissue engineering has made great strides in combating cardiovascular disease in modern society utilizing cardiac regenerative medicine as well as in vitro disease modeling. Stem cell-derived cardiomyocytes are a ... -
Design and Evaluation of an In Vivo, Repeatable, and Real Time Reporter for Myofibroblast Cell Fate as a Surrogate for Cardiac Fibrotic Remodeling
Heart disease is the leading cause of death in the United States accounting for 1 in every 4 deaths [“Heart Disease Facts”]. More than half of heart disease deaths are attributed to coronary heart disease which often leads ... -
Developing a library of recognition proteins using FimH as a protein scaffold
(2013-11-14)High specificity recognition proteins, like antibodies, are important biological tools with many applications, including diagnostics, therapeutics, and imaging. However, there are many challenges with antibody recognition ... -
Developing an Inducible Osteoclast System as a Cell Therapy for Ectopic Calcification
Ectopic calcification (EC) is a complex disease in which mineral develops in abnormal locations. It can develop in a variety of locations throughout the body, including the vasculature, heart valves, and in orthopedic ... -
Development and Application of Augmented Smartphone-enabled Imaging in Mobile Health
Mobile health techniques aim to deliver healthcare remotely and wirelessly using surging computing power and mobile connectivity. The commercial smartphone is naturally becoming a popular partner device due to its ... -
Development and Application of Multifunctional Optical Coherence Tomography
Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ... -
Development and Application of Multifunctional Optical Coherence Tomography
Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology ... -
Development and Optimization of Peptide-Based, Tumor-Associated Macrophage (TAM)-Targeting Therapeutics
Cancer is one of the leading causes of death and is a subject of intense research worldwide. Within the past few decades, cancer immunotherapy has emerged as an important arm of cancer therapies following the prominent ... -
Development of a Field-Use Paper-Based PKU Test Using Colorimetric Readout
Current newborn screening programs for phenylketonuria (PKU) do not reach many individuals, worldwide, who would benefit from testing. Existing PKU tests require a high-resource laboratory, as well as a base level of local ... -
Development of a Highly Sensitive Protein Diagnostic Device using Isothermal Strand Displacement Amplification
The lateral flow test (LFT) is the preferred tool for detection of protein biomarkers in low-resource settings. While low-cost and rapid, these immunoassay devices often suffer from limited sensitivity in the single chemical ... -
The development of a multi-model optical imaging system to investigate hemodynamic responses to tissue injury in vivo
(2014-04-30)Ischemic injury is caused by blockage or rupture of a blood vessel supplying an organ with oxygen and nutrients. A reduction of blood flow in the brain below critical values leads to a series of metabolic, functional, and ... -
Development of a Non-Instrumented Point-of-Care (POC) HIV-1 Diagnostic Device
(2013-11-14)There is a growing need for sensitive, simple, affordable and rapid detection of infectious disease biomarkers for faster access to test results and improved patient outcomes. The development of rapid, portable and accurate ... -
Development of a Novel Paper-Based Flu Test for Improved Diagnosis at the Point of Care
The development of paper-based diagnostics has surged in recent years, due to the suitability of these tests for use at the point of care. Paper-based diagnostics offer the ability to perform relatively sophisticated ... -
Development of activatable recognition proteins using the bacterial adhesin FimH
Recognition molecules, such as antibodies, are widely useful in many applications within bioengineering, or life sciences in general. However, the high cost and variability in antibodies has led to the development of ... -
Development of biomaterial porous scaffolds for dendritic cell modulation and mRNA delivery
mRNA has emerged as a potential candidate for vaccine applications in recent years as a versatile, safe, and cost-effective alternative to traditional therapeutics. Efficient delivery to antigen presenting cells and ...