Browsing Bioengineering by Title
Now showing items 1-20 of 356
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3D Printed Polypyrrole Microneedle Arrays for Electronically Controlled Transdural Drug Release
The secondary injury causes further damage to neural cells, due to mechanisms of inflammation and cytotoxicity. Progression of secondary injury damage may be reduced by the administration of anti-inflammatory drugs. In ... -
4D Control of Tissue Development and Blood Vasculature using Photo-mediated Chemistries
Organ function relies on the synergistic interactions and conserved organization between all its system components. Blood, blood vessels, extracellular matrix (ECM), and parenchyma interact dynamically, existing in a state ... -
A comparison of deep learning algorithms for medical image classification and image enhancement
In recent years, machine learning techniques based on neural networks have gained popularity. This is primarily because of improved computational capabilities and the availability of larger datasets. In our work, we ... -
A Computational Tool to Enhance Clinical Selection of Prosthetic Liners for People with Lower Limb Amputation
People with transtibial amputation experience a loss of mobility that results from the removal of propulsive and load bearing anatomy. The more delicate soft tissues of the residual limb are coupled to a hard prosthetic ... -
A Nanopatterned Cantilever Device for Assaying Contractile Properties of Stem Cell-Derived Cardiomyocytes
Drug-induced cardiotoxicity has been a major issue for both patients and pharmaceutical companies. Current in vitro cardiotoxicity screening utilizes genetically modified cell lines, which do not recapitulate adult human ... -
A Thermoresponsive Magnetic Nanoparticle System Using an Antiviral Lectin for HIV Capture and Concentration
Rapid tests have been developed as a method to diagnose HIV infection in resource-limited settings. However, several of these assays suffer from reduced sensitivity due to the limited sample volume. One approach to augment ... -
Accelerated Engineering of Optogenetic Tools with a High-throughput Microwell Array Platform
Optogenetics has shifted from a cutting-edge technology to a mainstay experimental technique. At its core, optogenetics is the use of light sensitive proteins to report or control biological activity. The unique spatiotemporal ... -
Activation of 96-Well Polypropylene Plates with Radio Frequency Plasma Ion Etching to Increase Chromatin Binding Capacity for Immunoprecipitation
Abstract:Activation of 96-Well Polypropylene Plates with Radio Frequency Plasma Ion Etching to Increase Chromatin Binding Capacity for Immunoprecipitation. Theodore Schrimshire. Chair of the Supervisory Committee: Dr. Karol ... -
Advancements in Optical Coherence Tomography: Innovations and Applications for Ophthalmology and Dermatology
Optical coherence tomography (OCT) is a well-established imaging modality widely used in ophthalmology and is emerging as a valuable clinical tool in dermatology. OCT angiography (OCTA), an advanced extension of OCT, ... -
Ambulatory Vascular Monitoring for Quantication of Lower Leg Hemodynamics and Severity of Venous Disease
Persons with chronic venous disease experience progressive deterioration of their lower extremity hemodynamics. Different factors are thought to contribute to this hemodynamic decline, including incompetent venous valves, ... -
An injectable gelatin-based delivery platform mediated by guest-host complexation
Injectable hydrogel systems are beneficial for various biomedical applications, including drug or cell delivery carriers, and tissue engineering scaffolds. In this work, we describe the design and characterization of a ... -
An integrated system for large volume sample processing at the point of care
The emergence of rapid, user-friendly, point-of-care (POC) diagnostic systems is paving the way for better disease diagnosis and control. Lately, there has been a strong emphasis on developing molecular-based systems due ... -
Analysis of defibrillation efficacy and investigation of impedance cardiography with finite element models incorporating anisotropic myocardium
(1999)Increasing defibrillation efficacy by estimating and lowering the defibrillation threshold (DFT) is important in positioning implantable defibrillating electrodes. We analyzed the relation between the experimentally-measured ... -
Analysis of the Ventricular Fibrillation Electrocardiogram During Cardiopulmonary Resuscitation to Predict Outcome of Out-of-Hospital Cardiac Arrest
Out-of-hospital ventricular fibrillation (VF) cardiac arrest results in approximately 50,000 deaths per year in the United States. Treatment includes defibrillation shock supported by cardiopulmonary resuscitation (CPR). ... -
Antibody-mediated SARS-CoV-2 entry and conformational regulation
Antibody-mediated entry (AME) of SARS-CoV-2 into monocytes and macrophages has been linked to activation of inflammatory phenotypes that are associated with severe COVID-19, but why only some antibodies mediate this entry ... -
Antigen Perception in T Cells
The immune system’s threat detection hinges on T cells’ ability to perceive differences in the quality and quantity of peptide-major histocompatibility complex (pMHC) antigens. Our T cells are tolerant to the vast majority ... -
Antithrombotic Peptide Delivery from Glow-Discharge Plasma-Coated Controlled Release Matrices
(University of Washington Graduate School, 2005-06-10)A novel polymeric matrix system has been developed to deliver agents to block platelet adhesion or inhibit thrombin activation on implanted biomaterials. The base material of the system used was BioSpan®, a medical-grade ... -
Application of functional optical coherence tomography angiography in neurovascular research
Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring ... -
Application of Logic Gate Regulated Constitutively Activated STAT Molecule for CAR T Cell Efficacy Improvement
Cancer is a complex disease, therefore the treatment methods used to address it should be robust enough to effectively combat it. Despite their general success, standard methods of treatment such as chemotherapy or radiation ... -
Aptamers and Peptides: Finding and Guiding CAR T Cells for Better Cancer Care
Chimeric antigen receptor (CAR) T-cell therapy has prompted a new age of cancer treatments, in which a patient’s T cells are genetically programmed with a cancer-targeting receptor ex vivo and reinfused for immune-mediated ...