Browsing Bioengineering by Title
Now showing items 24-43 of 356
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Beamforming Approaches for Ultrafast Nonlinear Ultrasound Imaging
Recent advances in ultrafast contrast imaging have facilitated innovations such as super-resolutionimaging and ultrafast contrast-enhanced Doppler imaging (Chapter 1). It has become evident that combining ultrafast imaging ... -
Bioengineering New Therapeutics for Pulmonary Infections
Pulmonary intracellular infections including tuberculosis, legionellosis, tularemia, and melioidosis present serious global health threats. Those intracellular infections, localized to the lung alveolar macrophage (AM), ... -
Bioimpedance Analysis to Determine the Effect of Pressure Release on Limb Fluid Volume Change in Persons with Transtibial Limb Loss
(2012-09-13)INTRODUCTION: Over 1 million Americans currently live with a lower limb amputation. Lower limb prostheses have been designed to produce a secure and comfortable fit between residual limb and prosthesis throughout the day. ... -
Biological Probes to Measure Transcription Dynamics in E. coli
RNA molecules exhibit dynamic behaviors that are critical to maintaining normal cell function, and their dynamic nature has been exploited to engineer biological systems. RNA dynamics processes that are often investigated ... -
Biological Water: Properties and Role in Muscle Function and Development
Water is the most abundant substance on planet Earth and present in large part of our daily lives. Despite such abundance, liquid water still remains mysterious for we do not understand its structure. Similarly, biological ... -
Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
(2013-11-14)Nanoparticles are emerging as versatile vehicles for drug delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) ... -
Biophysical strategies to inhibit bacterial amyloid formation and undermine biofilm infections
When bacteria dwell in biofilms on the surface of an implanted medical device or surgical site, cells co-associate using a self-produced extracellular matrix (EM), which acts as a layer of protection against antibiotic ... -
Bioprinting 3-Dimensional Skeletal Muscle Tissue Models Using Decellularized Extracellular Matrix
Developing biologically relevant models of human tissues and organs is an important enabling step for many applications within biological research and medicine. A specific application that physiologically relevant tissue ... -
Biosensor Platform Development for Studying Carbohydrate-Mediated Bacterial Adhesion
(2013-02-25)Infectious diseases are the second leading cause of mortality worldwide, accounting for 14.9 million deaths each year. Diarrheal diseases, usually a result of infection by enteric pathogens, cause 1.8 million of these ... -
CAR-EBD: Modular Polypeptide Devices for the Small Molecule Regulation of Chimeric Antigen Receptor T cell Activity
The advent of chimeric antigen receptor (CAR) T cell therapies holds immense promise for the future of cancer treatment. However, the vast majority of current CAR T cell therapies are self-guided, relying on endogenous ... -
Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
High intensity focused ultrasound (HIFU) is an emerging non-invasive ablation modality, in which high amplitude ultrasound waves are focused inside the human body to thermally ablate or mechanically disrupt the tissue at ... -
Characterization and Computational Evaluation of a Genetically Encoded Fluorescent Probe for Reactive Oxygen Species
Reactive Oxygen Species (ROS) are highly reactive chemical molecules that have essential roles in physiological processes. H2O2 is a relatively stable member of ROS family in aqueous environment and serves as an important ... -
Characterization of Coronary Arteries: Correlating Mechanical Stiffness with Staining for in vivo Imaging
Widespread prevalence of cardiovascular disease (CVD) in the US is indisputable. Over 82.6 million adults (~30% of the US population) have been diagnosed with one or more forms of CVD. Coronary artery disease (CAD) is the ... -
Characterization of regulation and expression patterns of Escherichia coli Hsp31 protein
(2006)Escherichia coli is exposed to a variety of environmental stresses in its natural habitats. On a cellular level, these stresses wreak havoc by disrupting the structure and function of proteins, which ultimately leads to a ... -
Characterization of Ultrasound Pressure Fields, Microbubbles and Their Interaction
Ultrasound’s therapeutic applications are increasing daily, and have spread in different medical fields, such as cardiology, sports medicine, urology, oncology, and even the field of cosmetics. Focused ultrasound (FUS) has ... -
Characterizing blood protein surface interactions for the development of thromboresistant fluoropolymer coatings
Patients with long term blood-contacting medical devices will continue to require risky systemic anticoagulant administration until the effects of device thrombogenicity can be adequately addressed. Adsorption of the ... -
Chemical Modification of Cellulose for Biomolecule Capture
(2012-09-13)Paper-based analytical devices are the subject of growing interest for the development of low-cost point-of-care diagnostics, environmental monitoring technologies, and research tools for limited-resource settings. However, ... -
Classification of Pain Intensity using Functional Connectivity Networks Derived from Intracranial Electroencephalography in Humans
Pain is an innate response most commonly arising from sensory and emotional stimuli reflecting injury or illness. Brain structures such as the anterior cingulate cortex, insula, and thalamus have been previously implicated ... -
Closed-Loop Neural Engineering Approaches to Motor Rehabilitation
Here I present several approaches to applying engineering design principles to the central nervous system with the goal of using closed-loop approaches to enhance rehabilitative processes. These approaches cover invasive ... -
Combinatorial maturation strategy for disease modeling and phenotypic drug screening of Duchenne muscular dystrophy cardiomyopathy
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer great promise for regenerative medicine, preclinical drug screening, and cardiac disease modeling applications. One of the most significant hurdles towards ...