Browsing Bioengineering by Title
Now showing items 33-52 of 356
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CAR-EBD: Modular Polypeptide Devices for the Small Molecule Regulation of Chimeric Antigen Receptor T cell Activity
The advent of chimeric antigen receptor (CAR) T cell therapies holds immense promise for the future of cancer treatment. However, the vast majority of current CAR T cell therapies are self-guided, relying on endogenous ... -
Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
High intensity focused ultrasound (HIFU) is an emerging non-invasive ablation modality, in which high amplitude ultrasound waves are focused inside the human body to thermally ablate or mechanically disrupt the tissue at ... -
Characterization and Computational Evaluation of a Genetically Encoded Fluorescent Probe for Reactive Oxygen Species
Reactive Oxygen Species (ROS) are highly reactive chemical molecules that have essential roles in physiological processes. H2O2 is a relatively stable member of ROS family in aqueous environment and serves as an important ... -
Characterization of Coronary Arteries: Correlating Mechanical Stiffness with Staining for in vivo Imaging
Widespread prevalence of cardiovascular disease (CVD) in the US is indisputable. Over 82.6 million adults (~30% of the US population) have been diagnosed with one or more forms of CVD. Coronary artery disease (CAD) is the ... -
Characterization of regulation and expression patterns of Escherichia coli Hsp31 protein
(2006)Escherichia coli is exposed to a variety of environmental stresses in its natural habitats. On a cellular level, these stresses wreak havoc by disrupting the structure and function of proteins, which ultimately leads to a ... -
Characterization of Ultrasound Pressure Fields, Microbubbles and Their Interaction
Ultrasound’s therapeutic applications are increasing daily, and have spread in different medical fields, such as cardiology, sports medicine, urology, oncology, and even the field of cosmetics. Focused ultrasound (FUS) has ... -
Characterizing blood protein surface interactions for the development of thromboresistant fluoropolymer coatings
Patients with long term blood-contacting medical devices will continue to require risky systemic anticoagulant administration until the effects of device thrombogenicity can be adequately addressed. Adsorption of the ... -
Chemical Modification of Cellulose for Biomolecule Capture
(2012-09-13)Paper-based analytical devices are the subject of growing interest for the development of low-cost point-of-care diagnostics, environmental monitoring technologies, and research tools for limited-resource settings. However, ... -
Classification of Pain Intensity using Functional Connectivity Networks Derived from Intracranial Electroencephalography in Humans
Pain is an innate response most commonly arising from sensory and emotional stimuli reflecting injury or illness. Brain structures such as the anterior cingulate cortex, insula, and thalamus have been previously implicated ... -
Closed-Loop Neural Engineering Approaches to Motor Rehabilitation
Here I present several approaches to applying engineering design principles to the central nervous system with the goal of using closed-loop approaches to enhance rehabilitative processes. These approaches cover invasive ... -
Combinatorial maturation strategy for disease modeling and phenotypic drug screening of Duchenne muscular dystrophy cardiomyopathy
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer great promise for regenerative medicine, preclinical drug screening, and cardiac disease modeling applications. One of the most significant hurdles towards ... -
Combining Silicon Photonics and Machine Learning for Red Blood Cell Characterization
Tens of millions of units of blood are transfused worldwide each year, with each individual unit requiring manual typing by a trained technician prior to transfusion. Several tools exist to help expedite the typing process, ... -
Comparing the release rates of ciprofloxacin from different polymer structures with different linker chemistries
Polymeric prodrugs of ciprofloxacin for inhalation are attractive alternatives to orally-administered free ciprofloxacin and inhalable liposomal formulations. This study investigated the release kinetics of ciprofloxacin ... -
Comparison of Different Methods on EEG Signal Separating of Stuttering Adult and Child During the Pre-speech Auditory Modulation
During the Event-related potential (ERP) study, ideally, the EEG recording only contains the event-related signal. However, there could exist irrelevant signals and noise. Unconscious activities, such as eye movement and ... -
Comprehensive automated analysis of three-dimensional brain cell-resolution imaging data
Neuroimaging techniques provide immensely valuable data for medical professionals and academic researchers alike, but analysis of these data is difficult and often relies on subjective interpretations. This project proposes ... -
Compressive cervical spine injury: the effect of injury mechanism on structural injury pattern and neurologic injury potential
(2002)Cervical spine trauma resulting in spinal cord injury is a particularly devastating musculoskeletal injury. Every year thousands of individuals are added to the ranks of those afflicted by it. And, the associated socioeconomic ... -
Computational and Experimental Advances in Clinically Relevant Neurostimulation of Non-Human Primates
Neural engineering capabilities in non-human primates (NHPs) dramatically lag the capabilities in rodents, despite NHPs being the most neurophysiologically similar animal model to humans. This work puts forward advances ... -
Computational design and optimization of protein-protein interactions to engineer novel binders of Influenza Hemagglutinin
Influenza is a serious public health concern and new therapeutics that protect against this highly adaptable virus are urgently needed. For this dissertation my efforts were focused on creating and improving de novo designed ... -
Computational design of de novo protein nanoparticles for RNA delivery
Several non-porous RNA encapsulating protein nanoparticles have been reported, but none have been shown to deliver nucleic acids to mammalian cells. Here, I will discuss my efforts to optimize the topology of a de novo ... -
Computational design of interleukin-2 mimetics
Interleukin-2 is a cytokine that plays a central role in immune system homeostasis, exerting paradoxical immunostimulatory and immunoregulatory effects based on its interactions with various receptor subunits differentially ...