Browsing Bioengineering by Title
Now showing items 252-271 of 356
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Nanomaterial Strategies to Enhance Antiretroviral Efficacy for Vaginal Drug Delivery
HIV continues to infect millions of people worldwide, and without an effective vaccine or cure available, there is need for new methods to prevent infection. Women are disproportionately impacted by HIV due to biologic ... -
Neural correlates of human motor planning and visuomotor transformation
Goal-oriented coordinated movement is an everyday feat of computation, the mundaneness of which belies its immense complexity. When we lose function in disease or injury, however, we realize that our understanding of the ... -
Neural correlates of learning and intent during human brain-computer interface use
Brain-computer interface (BCI) technologies can potentially be used restore function in patients with severe motor disorders, however, BCI devices currently do not perform well enough to warrant the risk or expense relative ... -
Neutral Polymeric Micelles for RNA Delivery
(2013-11-14)Small interfering RNA (siRNA) is a therapeutic gene silencing strategy that has generated substantial interest in the scientific community, but it remains a challenge to produce a robust and nontoxic systemic delivery ... -
Novel aptamer development for cell isolation and targeted drug delivery
Aptamers are oligonucleotides that can bind to their targets with high affinity. These “chemical antibodies” provides numerous advantages over their biological counter parts. It is discussed in chapter 1 that aptamers are ... -
Novel backbone methods for de novo protein design
Solving a protein design problem first requires sampling suitable backbones given the needs and constraints of the problem. The available structural space of backbones is vast, containing countless potential solution ... -
Novel Biodegradable Polymer based on Low Molecular Weight Hydrolyzing Units
Polymer scaffolds can be used to restore, maintain, or improve tissues and organs. Poly(2-hydroxyethyl methacrylate), also known as pHEMA, is a commonly used polymer in tissue engineering due to its versatility in application. ... -
On the Auxiliary Driving Mechanism for Blood Circulation
This thesis discusses a driving mechanism for blood circulation over and above the pressure gradient. Fluid commonly flows in response to an external pressure gradient. However, when a tunnel-containing hydrogel is immersed ... -
Oncoslice: A Microfluidic Platform for Personalized Cancer Care and Drug Development
Improving efficacy, minimizing the adverse side effects of drugs, and overcoming acquired resistance to drug treatment have been major goals and emphases in cancer therapy. Existing models of drug activity (based on tumor ... -
Ophthalmic Application of Optical Coherence Tomography Angiography for Retina and Choroidal Imaging
Optical coherence tomography (OCT) angiography (OCTA) is a revolutionary non- invasive imaging modality that has been widely utilized in ophthalmology. OCT and OCTA has huge potentials for quantitative analysis based on ... -
Ophthalmic Application of Optical Coherence Tomography Based Angiography for Choroidal Imaging
We demonstrated in vivo choriocapillaris imaging in normal human subjects with a Cirrus HD 5000 spectral domain OCT prototype. With the tracking system installed in the prototype and the montage scanning protocol, wide ... -
Optical coherence tomography for quantitative analyses of cerebral vessel morphology and hemodynamics
The brain plays a crucial role in life-sustaining activities of human, including consciousness, logical thinking, emotional feeling, memory storage, somatic movement, and communication. As the most complex but least ... -
Optical Coherence Tomography for the Assessment of Skin Adaptation to Repetitive Mechanical Stress
Skin breakdown is a problem that affects many individuals with lower limb loss. Breakdown is caused most commonly by repetitive mechanical stresses that are imposed on the residual limb at its interface with the prosthetic ... -
Optical Mapping of Human Embryonic Stem Cell-Derived Cardiomyocyte Graft Electrical Activity in Injured Hearts
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac repair. hESC-CMs can be efficiently generated in high numbers for cardiac transplantation, have been shown to form stable ... -
Optimizing Markerless Motion Tracking for the Study of Hand Kinematics
To facilitate studies investigating motor movements and learning mechanisms involved in complex kinematic tasks, there is need for effective real time 3D motion tracking. Current methodologies for motion tracking are ... -
Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery
Image-based surgical navigation offers improved integration of preoperative planning with intraoperative execution and documentation. Registration is a fundamental step in all surgical navigation procedures and entails the ... -
Peptide-functionalized Biomaterials for Hemostasis and Cancer Imaging
Molecular recognition drives all biological processes and can be leveraged to engineer a broad range of biomaterials for detection and treatment of altered states in the body. Part I of this dissertation focuses on the use ... -
pH-responsive polymers for nucleic acid and vaccine delivery
Biomacromolecules such as nucleic acids and peptides have great potential as therapeutics but must overcome many challenging biological barriers to succeed in the clinic. In this work, we present several investigations of ... -
Phase Sensitive MRI and its Application to Cardiovascular Diseases
Inversion recovery phase sensitive (IRPS) imaging is a T1 weighted magnetic resonance imaging(MRI) method and its T1 contrast is introduced by a $180^{o}$ radio frequency(RF) pulse. IRPS image keeps the polarity map and ... -
Photo-switching of protein activities by conjugation of photo-responsive polymers to proteins
(2001)Photo-switching of protein functions has recently become more actively investigated by many researchers. Our objective is to create novel photo-switchable proteins by conjugating photo-responsive polymers to proteins ...