Browsing Bioengineering by Title
Now showing items 280-299 of 356
-
Quantification of DNA content using 3D Optical Projection Tomographic Microscopy for Early Cancer Diagnosis
(2014-02-24)Aneuploidy, an accepted biomarker for malignancy, is typically assessed by flow (FCM) and image cytometry (ICM). We used optical projection tomographic microscopy (OPTM) for assessing cellular DNA content using different ... -
Quantification of Multimodal Fluorescence Imaging for Cancer Detection, Guiding Biopsy and Guiding Surgery
Fluorescence imaging is emerging for guiding biopsy, early cancer detection and guiding surgery, with the development of new molecularly selective fluorescence agents and fluorescence imaging systems. Accurate quantification ... -
Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology
Optical coherence tomography (OCT) angiography (OCTA) is a recently developed non-invasive functional imaging technique that have been widely utilized in ophthalmology. OCTA is capable of providing three dimensional detailed ... -
Quantitative Computational and Experimental Characterization of Functionalized Nanoparticles
Nanoparticles are widely used in many fields of science and can often be found in everyday commercial products. This widespread use of nanoparticles in our daily lives and the industry have raised several concerns regarding ... -
Quantitative Objective Assessment of Preoperative Warm-up for Robotic Surgery
(2013-11-14)Here I present the application of three established methods for quantitatively and objectively assessing robotic surgical performance as well the development and application of a fourth. These four tools are used to assess ... -
Quantum Dot Platform for Single-Cell Molecular Profiling
(2013-07-23)In-depth understanding of the nature of cell physiology and ability to diagnose and control the progression of pathological processes heavily rely on untangling the complexity of intracellular molecular mechanisms and ... -
Rapidly prototyping complex microfluidics through stereolithography
As organ-on-a-chip research becomes more popular, greater effort is being placed into creating in vitro cell culture systems that more accurately represent the complexity of in vivo biology. Microfluidics, or the manipulation ... -
Real-time Three-Dimensional DNA Microarrays: How Well Can We Distinguish Between Related Target Sequences?
(2013-04-17)DNA microarrays, due to their highly parallel nature, are in principle well suited for rapid identification of known or related microbial species, but our ability to extract meaningful information from microarray images ... -
Reduction of CT dose for CT-based PET attenuation correction
(2013-02-25)One important goal of quantitative imaging using positron emission tomography (PET) combined with X-ray computed tomography (CT) is to accurately measure a tumor's characteristics both before and during therapy to determine ... -
Reduction of Off-Axis Clutter in Plane-wave Ultrasound Imaging
In ultrasound imaging, an abrupt change in medium, such as the interface between tissue and bone can have a dramatic effect on the image. A bone-tissue interface strongly reflects acoustic signals in comparison to soft ... -
Regenerative matrices for oriented bone growth in craniofacial and dental repair
(2007)Non-healing fractures can result from trauma, disease, or age-related bone loss. While many treatments focus on restoring bone volume, few try to recapitulate bone organization. However, the native architecture of bone is ... -
Regulation of In Vivo Mitochondrial Energetics by Oxidative Stress throughout Life: A Multi-Modal Spectroscopy Approach
(2012-09-13)Age-related skeletal muscle degeneration contributes to lost quality of life and an increased health care burden for the aging population. At the crossroads of energy production, cell signaling, and free-radical production, ... -
Reproducible, Robust, and Reliable Biochemical Reaction Network Models for Systems Biology
Reproducibility, robustness, and reliability are features desired for a biochemical reaction network model. Scientific research is reproducible when the findings can be independently verified and reproducibility is crucial ... -
Repurposing DNA for information processing and storage
DNA is the principal carrier of biological information. It is present in nearly all forms of life and it enables the transfer of genetic information between many generations. Beyond its natural role, DNA is also a programmable ... -
Resonating Fluidic Circuits: A Novel Technology to Create a Portable Blood Viscoelasticity Measuring Device
The prehospital detection of coagulopathy has been identified as an important goal for the future of emergency medicine and trauma care. However, no clinically accepted devices that can diagnose coagulopathy by measuring ... -
Restoring function after neuromuscular trauma: novel paradigms for enhancing volitional control of neural activity in untethered environments and vHAB, a gamified therapy platform
Individuals suffering from neuromuscular traumas, such as stroke and spinal cord injury, face limited options in regaining motor function after injury. Emerging methods in brain-machine interfaces aim to assist individuals ... -
Role of endothelin signaling in osteochondrogenic differentiation and matrix calcification of vascular smooth muscle cells
(2013-07-25)Type II diabetes mellitus (T2DM) and high serum levels of endothelin-1 (ET1) are associated with accelerated ectopic calcification of blood vessels. Most often, this calcification occurs in the medial layer, a layer populated ... -
The role of osteopontin in macrophage-mediated inflammation
(2012-09-13)Osteopontin (OPN) is highly expressed by macrophages and plays a key role in the pathology of several chronic inflammatory diseases. Macrophages are central players in chronic inflammation and OPN orchestrates macrophage ... -
The Role of the Ankle Plantar Flexors During Running with Different Strike Patterns
Different strike patterns result in differences in kinematics and kinetics during running. The objective of this study was to examine differences in muscle activation in rearfoot stike (RFS) and nonrearfoot strike (nRFS) ... -
Role of Vascular Smooth Muscle Cell PiT-2 in Basal Ganglia Calcification
Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder that can be inherited in an autosomal dominant manner. The disease is characterized by bilateral calcium phosphate salt deposition primarily ...