Browsing Bioengineering by Title
Now showing items 114-133 of 356
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Effects of inflammatory conditions on the structure of fibrin clots: modeling a flexible protein dimer with molecular dynamics simulations
Upon vascular injury, fibrin is converted from fibrinogen and polymerizes to form long protofibrils. Protofibrils laterally aggregate via the αC domain to form fibrin fibers, which bind to platelets and form a clot. ... -
Effects of Nanotopography on Structural Maturation and Differentiation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Heart diseases remain the leading cause of morbidity and mortality worldwide. As damages done to the heart are irreversible, heart transplant is the ultimate therapy, but it is greatly limited by the shortage of heart ... -
Effects of the MYH7 R369Q Dilated Cardiomyopathy-causing Mutation on Myosin Crossbridge Kinetics and Cardiomyocyte Contractility
The R369Q mutation in the MYH7 gene is a likely pathogenic variant of familial dilated cardiomyopathy (DCM). This mutation is located in loop 4 of β-myosin heavy chain actin-binding surface and may alter actin-myosin ... -
Electronics Design for a Portable, Disposable Ultrasound Guidance System for Intracranial Pressure-Relieving Surgical Procedures
(2012-09-13)Catheterization is a common procedure used to relieve excess pressure in the brain during cases of hydrocephalus. However, the vast majority of catheterizations are guided using only external anatomical landmarks for ... -
Electrospun Fibers for HIV Prevention: Translational Design for In Vivo Efficacy
Women are disproportionately affected by the HIV epidemic, especially in sub-Saharan Africa, where the majority of the world’s HIV burden is located. The development of female-initiated protection methods is motivated by ... -
Electrospun fibers for the prevention of human immunodeficiency virus
HIV/AIDS education, testing, and treatment have thus far failed to cease the pandemic spread of the HIV virus. HIV prevention is hindered by a lack of protective options beyond the ABC approach of abstinence, being faithful, ... -
Electrospun fibers for the prevention of human immunodeficiency virus
HIV/AIDS education, testing, and treatment have thus far failed to cease the pandemic spread of the HIV virus. HIV prevention is hindered by a lack of protective options beyond the ABC approach of abstinence, being faithful, ... -
Elevated Phosphate-Induced Cell Signaling through Phosphate Transporter PiT-1 in Vascular Smooth Muscle Cells
Vascular calcification (VC) is prevalent in chronic kidney disease and elevated serum inorganic phosphate (Pi) is a recognized risk factor. The type III sodium-dependent phosphate transporter, PiT-1, is required for ... -
Enable Placental Extracellular Vesicle Isolation Using Binary Temperature-responsive Reagent System
Extracellular vesicles (EVs) are cell-secreted lipid bilayer vesicles which play important roles in human cell signaling. In recent years, the researches regarding the placenta derived EVs which are secreted from the ... -
Enabling Brain-Computer Interface Co-Adaptation with Performance-Related Signals
Brain-Computer Interfaces (BCIs) have the potential to positively impact the lives of many people with sensorimotor disabilities due to neurological conditions, such as spinal cord injury and stroke. Through BCIs, individuals ... -
Endosomolytic Biomaterial Vaccines for Cancer Therapy
Stimuli-responsive biomaterials are useful for a variety of therapeutic applications because they function in concert with naturally occurring biological processes. This dissertation is focused on applications of a ... -
Endothelial cell interactions with model surfaces: effect of surface chemistry, surface mobility, and the adsorbed protein layer
(1999)The clinical success of the small diameter vascular graft remains limited due to occlusion resulting from thrombus formation. Methods for promoting graft endothelialization have been investigated to improve graft healing. ... -
Engineered Cardiac Troponin C Structure-Function Studies: Designing Proteins for Treatment of Cardiomyopathies
(2013-04-17)The functional effects of mutations associated with cardiomyopathies generally suggest that the Ca2+ responsiveness of the myofilament was affected. This functional change appears to be independent of which protein contains ... -
Engineered Fibrin Scaffolds for Cardiac Tissue Repair
(2013-07-25)Myocardial infarction (MI) causes significant cell loss and damage to myocardium. Cell-based therapies for treatment of MI aim to remuscularize the resultant scar, but the majority of transplanted cells do not survive or ... -
Engineered microvessels for improved integration with host coronary circulation and for the generation of pre-vascularized cardiac constructs
Engineered cardiovascular tissues are at the forefront of regenerative medicine research and have the potential to redefine the treatment of heart disease in the United States and worldwide. There are many challenges ... -
Engineered Platforms for Molecular Characterization of Human ABO Blood Type Antigens
The most prevalent typing procedures are based on the overly simplified characterization of erythrocyte membrane antigens into the commonly known ABO blood group system. Numerous subgroups of ABO have been described that ... -
Engineering 3D Human Cardiac Ventricular Models with Controllable Architecture
Tissue engineering combined with the power of stem cell technology provides unprecedented opportunity to interrogate and discover human biology. The derivation of human cardiomyocytes from induced pluripotent stem cells ... -
Engineering a Decorin Surface Coating and Evaluating the Role of Decorin in the Foreign Body Response to Implants
(2013-02-25)Encapsulation of medical devices after implantation leads to reduced functionality and device failure of long term implants. To improve healing around implants, and allow long-term implant functionality, the prevention ... -
Engineering a Novel Device to Implement Afterload on Human Stem Cell-Derived Cardiac Tissues
Cardiac tissue engineering is a promising approach towards regenerating healthy myocardium and restoring the function of infarcted hearts. Using human embryonic stem cell (hESC) derived cardiomyocytes seeded in a collagen ... -
Engineering and Evaluating Fibrin-Targeted Biomaterials for Hemostasis
Traumatic injury incurs a heavy burden on both civilian and military populations throughout the world, and a large proportion of these deaths are due to hemorrhage, or uncontrolled bleeding. Current interventions are not ...