Browsing Bioengineering by Title
Now showing items 161-180 of 356
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Fabrication and Characterization of an Acellular Human Kidney ECM-derived Hydrogel
Today, more than 900,000 patients in the United States live with end-stage renal disease, with many more suffer from poor renal regeneration1. Current methods commonly use synthetic tissue-engineered constructs to deliver ... -
Fast and Modular Biomolecular Circuits using Spatial Organization
“Biological information processing hubs” ranging from brain to cells to enzyme cascades extensively use spatial organization to process massively parallel molecular instructions and accurately respond to external and ... -
Field-deployable microfluidics for species identification in conservation
This work explores the development of anisotropic ratchet conveyors (ARCs), a type of microfluidic system that can transport small liquid quantities in the form of droplets. ARCs derive their function from a passive, ... -
Field-deployable system for the detection and measurement of micronutrients
Micronutrient deficiency is a global problem affecting billions of people world-wide. A lack in any of vitamin A, zinc, iron, folic acid or iodine can result in major health defects which can greatly reduce quality of life. ... -
Fluorescence anisotropy near-field scanning optical microscopy (FANSOM): a new technique for biological microviscometry
(2001)To test hypotheses regarding putative roles of water structuring in cell function, a near-field scanning optical microscope system was implemented and adapted for nano-scale fluorescence anisotropy measurement. Technical ... -
Fluorescence Detection of DNA Amplification in Porous Media for Point-of-Care Diagnostics
The translation of sophisticated, laboratory-developed methods for disease diagnosis into devices appropriate for locations with limited infrastructure—whether that is a military setting, resource-poor country, or a ... -
Force Generation and Cytoskeletal Structure of Single Platelets
Cardiovascular disease is the most common cause of death worldwide, and one in four deaths is related to dysfunctional blood clotting. Platelet forces are an emerging metric for the balance of clotting and bleeding due to ... -
Functional De Novo Proteins as Custom Molecular Tools for Bioengineering: from Targeted Cancer Immunotherapy to Modular Biosensors
Traditional protein engineering methods use naturally existing proteins as a starting point and are intrinsically limited to small perturbations of a protein’s original structure and function. Computational de novo protein ... -
Gait Effects of Unexpected and Coronally-Uneven Terrain on Healthy Adults
In the United States, falls are the number one cause of death and injury in adults over the age of 65. Many of these falls occur in the mediolateral direction and are attributed to extrinsic factors, such as uneven terrain. ... -
Gas-vapor bubble dynamics in therapeutic ultrasound
(2008)In applications of therapeutic ultrasound such as shock wave lithotripsy (SWL) and high-intensity focused ultrasound (HIFU), cavitation and the associated bubble dynamics play an important role. Moreover, bubble dynamics ... -
Genetic Selection of Cardiomyocytes and Pacemaker Cells Derived From Human Embryonic Stem Cells
(2013-07-25)Cardiomyocytes derived from human pluripotent stem cells are poised to transform heart disease treatment. However, current methods to produce stem cell-derived cardiomyocytes result in a mixture of cardiac phenotypes that ... -
Genetically Engineered Human Stem Cell-Derived Cardiomyocytes to Study the Novel Titin Isoform Cronos in Development and Disease
The giant sarcomere protein titin plays a number of important roles in the cardiomyocyte, and truncating mutations to the gene that encodes this protein (TTN) are the leading known cause of dilated cardiomyopathy. Despite ... -
Glassy Carbon μECoG Electrode Array for In-vivo Sensing and Stimulation
Current neural-prosthetic devices fail to provide high-quality signals with good resolution for long periods of time. This is due to changes in the device-tissue interface, mostly in the form of device degradation and ... -
Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
Intracellular pathogens are a major cause of global morbidity and mortality due to their complex and intricate ability to replicate within host cells while evading the innate immune defense system. Many intracellular ... -
Growth and function of transgenic endocrine cells on silanized surfaces
(2001)Interactions of transplantable cells with synthetic polymers might influence the function of biohybrid artificial organs. This study explored growth and secretion of human insulin by transgenic betaG I/17 insulinoma cells ... -
Heat, Fluid, and Sample Control in Point-of-Care Diagnostics
Point-of-care diagnostics have transformed healthcare workflow, perhaps most notably in the wide-reaching impact of home pregnancy tests. Lateral flow strips are simple and inexpensive, but limited in their application to ... -
High-intensity focused ultrasound (HIFU) induced hyperechoic regions for the ultrasound guidance of HIFU therapy
(2004)High Intensity Focused Ultrasound (HIFU) treatment of soft tissues has been shown to result in a hyperechoic region in B-mode ultrasound (US) images. The goals of this project were to gain an understanding of the mechanisms ... -
High-Throughput Characterization of Protein-Protein Interactions by Reprogramming Yeast Mating
High-throughput methods for screening protein-protein interactions enable the rapid characterization of engineered binding proteins and interaction networks. While existing approaches are powerful, none allow quantitative ... -
Highly Parallel Tissue Grafting for Combinatorial In Vivo Screening
Material- and cell-based technologies such as engineered tissues hold great promise as human therapies. Yet, the development of many of these technologies becomes stalled at the stage of pre-clinical animal studies due to ... -
Human Engineered Heart Tissues as an In Vitro Model of Duchenne Muscular Dystrophy
Cardiomyopathy is the leading cause of death for patients with Duchenne muscular dystrophy (DMD), a severe, degenerative muscular disorder. This disease results from the lack of functional dystrophin, a protein that localizes ...