Browsing Bioengineering by Title
Now showing items 169-188 of 356
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Gait Effects of Unexpected and Coronally-Uneven Terrain on Healthy Adults
In the United States, falls are the number one cause of death and injury in adults over the age of 65. Many of these falls occur in the mediolateral direction and are attributed to extrinsic factors, such as uneven terrain. ... -
Gas-vapor bubble dynamics in therapeutic ultrasound
(2008)In applications of therapeutic ultrasound such as shock wave lithotripsy (SWL) and high-intensity focused ultrasound (HIFU), cavitation and the associated bubble dynamics play an important role. Moreover, bubble dynamics ... -
Genetic Selection of Cardiomyocytes and Pacemaker Cells Derived From Human Embryonic Stem Cells
(2013-07-25)Cardiomyocytes derived from human pluripotent stem cells are poised to transform heart disease treatment. However, current methods to produce stem cell-derived cardiomyocytes result in a mixture of cardiac phenotypes that ... -
Genetically Engineered Human Stem Cell-Derived Cardiomyocytes to Study the Novel Titin Isoform Cronos in Development and Disease
The giant sarcomere protein titin plays a number of important roles in the cardiomyocyte, and truncating mutations to the gene that encodes this protein (TTN) are the leading known cause of dilated cardiomyopathy. Despite ... -
Glassy Carbon μECoG Electrode Array for In-vivo Sensing and Stimulation
Current neural-prosthetic devices fail to provide high-quality signals with good resolution for long periods of time. This is due to changes in the device-tissue interface, mostly in the form of device degradation and ... -
Glycan polymeric prodrugs against pulmonary intracellular alveolar infections
Intracellular pathogens are a major cause of global morbidity and mortality due to their complex and intricate ability to replicate within host cells while evading the innate immune defense system. Many intracellular ... -
Growth and function of transgenic endocrine cells on silanized surfaces
(2001)Interactions of transplantable cells with synthetic polymers might influence the function of biohybrid artificial organs. This study explored growth and secretion of human insulin by transgenic betaG I/17 insulinoma cells ... -
Heat, Fluid, and Sample Control in Point-of-Care Diagnostics
Point-of-care diagnostics have transformed healthcare workflow, perhaps most notably in the wide-reaching impact of home pregnancy tests. Lateral flow strips are simple and inexpensive, but limited in their application to ... -
High-intensity focused ultrasound (HIFU) induced hyperechoic regions for the ultrasound guidance of HIFU therapy
(2004)High Intensity Focused Ultrasound (HIFU) treatment of soft tissues has been shown to result in a hyperechoic region in B-mode ultrasound (US) images. The goals of this project were to gain an understanding of the mechanisms ... -
High-Throughput Characterization of Protein-Protein Interactions by Reprogramming Yeast Mating
High-throughput methods for screening protein-protein interactions enable the rapid characterization of engineered binding proteins and interaction networks. While existing approaches are powerful, none allow quantitative ... -
Highly Parallel Tissue Grafting for Combinatorial In Vivo Screening
Material- and cell-based technologies such as engineered tissues hold great promise as human therapies. Yet, the development of many of these technologies becomes stalled at the stage of pre-clinical animal studies due to ... -
Human Engineered Heart Tissues as an In Vitro Model of Duchenne Muscular Dystrophy
Cardiomyopathy is the leading cause of death for patients with Duchenne muscular dystrophy (DMD), a severe, degenerative muscular disorder. This disease results from the lack of functional dystrophin, a protein that localizes ... -
Human organ-specific vascular heterogeneity and the endothelial role in fetal liver hematopoiesis
For a long time, the endothelium was considered to be a homogenous passive surface that existed primarily to support blood flow. In recent decades, however, both the heterogeneity of the endothelium and its importance in ... -
Human psychophysics of direct cortical stimulation of somatosensory cortex
Feedback is a vital part of any control system, and somatosensory feedback is essential for efficient and precise movement. Thus, future rehabilitative brain-computer interfaces (BCIs), such as neuroprostheses, require the ... -
Identification and Characterization of M2 Macrophage-targeting Peptide M2pep for the Delivery of Pro-apoptotic Peptides to Tumor-associated Macrophages
Activated macrophages are made up of two broad subsets, M1 “classically activated” macrophages and the M2 “alternatively activated” macrophages. These subsets present diverse functional phenotypes, with M1 macrophages ... -
Identifying the Origins of Bone Loss Induced by Transient Muscle Paralysis Using Novel MicroCT Image Registration Techniques
(2014-02-24)The co-dependency of bone and muscle is exemplified by concomitant catabolic and/or anabolic tissue adaptations, as induced by respective decreases or increases in mechanical loading. Given that muscular contraction is ... -
Image-guided high intensity focused ultrasound treatment for uterine leiomyomata
(2003)High Intensity Focused Ultrasound, or HIFU, is capable of treating tissue deep in the body without the need for surgery. With this premise, an ultrasound image-guided HIFU device has been developed for treating submucosal ... -
Imaging Corneal Stiffness with Optical Coherence Elastography
Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of corneal stiffness. Corneal stiffness measurements may enable an individualized biomechanical model of the eye, ... -
Immunoengineering nanoparticles for mucosal drug and vaccine treatment of sexually transmitted infections
Sexually transmitted infections (STIs) are a major burden on human health worldwide, accounting for nearly 1 million infections daily. Women’s sexual and reproductive health is disproportionately impacted by the most ... -
Immunofluorescence of Intracellular Targets in Live Cells
Every second, living human cells are executing complex functions to initiate or influence various processes such as energy production, growth, metabolism and reproduction. This also means that intracellular structures are ...