Browsing Bioengineering by Title
Now showing items 176-195 of 356
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Heat, Fluid, and Sample Control in Point-of-Care Diagnostics
Point-of-care diagnostics have transformed healthcare workflow, perhaps most notably in the wide-reaching impact of home pregnancy tests. Lateral flow strips are simple and inexpensive, but limited in their application to ... -
High-intensity focused ultrasound (HIFU) induced hyperechoic regions for the ultrasound guidance of HIFU therapy
(2004)High Intensity Focused Ultrasound (HIFU) treatment of soft tissues has been shown to result in a hyperechoic region in B-mode ultrasound (US) images. The goals of this project were to gain an understanding of the mechanisms ... -
High-Throughput Characterization of Protein-Protein Interactions by Reprogramming Yeast Mating
High-throughput methods for screening protein-protein interactions enable the rapid characterization of engineered binding proteins and interaction networks. While existing approaches are powerful, none allow quantitative ... -
Highly Parallel Tissue Grafting for Combinatorial In Vivo Screening
Material- and cell-based technologies such as engineered tissues hold great promise as human therapies. Yet, the development of many of these technologies becomes stalled at the stage of pre-clinical animal studies due to ... -
Human Engineered Heart Tissues as an In Vitro Model of Duchenne Muscular Dystrophy
Cardiomyopathy is the leading cause of death for patients with Duchenne muscular dystrophy (DMD), a severe, degenerative muscular disorder. This disease results from the lack of functional dystrophin, a protein that localizes ... -
Human organ-specific vascular heterogeneity and the endothelial role in fetal liver hematopoiesis
For a long time, the endothelium was considered to be a homogenous passive surface that existed primarily to support blood flow. In recent decades, however, both the heterogeneity of the endothelium and its importance in ... -
Human psychophysics of direct cortical stimulation of somatosensory cortex
Feedback is a vital part of any control system, and somatosensory feedback is essential for efficient and precise movement. Thus, future rehabilitative brain-computer interfaces (BCIs), such as neuroprostheses, require the ... -
Identification and Characterization of M2 Macrophage-targeting Peptide M2pep for the Delivery of Pro-apoptotic Peptides to Tumor-associated Macrophages
Activated macrophages are made up of two broad subsets, M1 “classically activated” macrophages and the M2 “alternatively activated” macrophages. These subsets present diverse functional phenotypes, with M1 macrophages ... -
Identifying the Origins of Bone Loss Induced by Transient Muscle Paralysis Using Novel MicroCT Image Registration Techniques
(2014-02-24)The co-dependency of bone and muscle is exemplified by concomitant catabolic and/or anabolic tissue adaptations, as induced by respective decreases or increases in mechanical loading. Given that muscular contraction is ... -
Image-guided high intensity focused ultrasound treatment for uterine leiomyomata
(2003)High Intensity Focused Ultrasound, or HIFU, is capable of treating tissue deep in the body without the need for surgery. With this premise, an ultrasound image-guided HIFU device has been developed for treating submucosal ... -
Imaging Corneal Stiffness with Optical Coherence Elastography
Optical coherence elastography (OCE) can provide clinically valuable information based on local measurements of corneal stiffness. Corneal stiffness measurements may enable an individualized biomechanical model of the eye, ... -
Immunoengineering nanoparticles for mucosal drug and vaccine treatment of sexually transmitted infections
Sexually transmitted infections (STIs) are a major burden on human health worldwide, accounting for nearly 1 million infections daily. Women’s sexual and reproductive health is disproportionately impacted by the most ... -
Immunofluorescence of Intracellular Targets in Live Cells
Every second, living human cells are executing complex functions to initiate or influence various processes such as energy production, growth, metabolism and reproduction. This also means that intracellular structures are ... -
Implementing an Integrate-and-Fire Neural Network on a Bidirectional Brain-Computer Interface
There is a growing interest in using intracortical microstimulation (ICMS) as a means of neurorehabilitation, from using it to rewire synaptic connections in the brain, to providing a means of providing artificial sensations ... -
Improvement of Vibration and End-to-End Latency for Optical Motion Detection System in Magnetic Resonance Imaging
This dissertation presents improvements to both software and hardware for a marker-less optical motion detection system used in magnetic resonance imaging. Multiple devices have been developed to eliminate artifacts in MRI ... -
Improving diagnosis of tuberculosis from urine cell-free DNA
Tuberculosis (TB) is the leading cause of infectious disease-related mortality worldwide, in part due to limitations in rapid diagnostics. Current TB tests rely on sputum samples, which are difficult to collect from many ... -
Improving the Contractile Performance of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Cell Therapy
(2013-07-25)Heart disease is the leading cause of death worldwide, and each year over 1 million Americans suffer from a myocardial infarction, with many subsequently developing heart failure. Our labs have worked extensively to develop ... -
Increased Anatomical Specificity for Neuromodulation Using Modulated Focused Ultrasound
Transcranial ultrasound can alter brain function transiently and nondestructively, offering a new tool to study brain function now and to inform future therapies. Previous research on neuromodulation implemented pulsed ... -
Increased sensitivity for lateral flow immunoassays through signal amplification methods
The simple and inexpensive sandwich-immunoassay-based lateral flow tests (LFTs, also known as lateral flow immunoassays, LFIAs, and rapid diagnostic tests, RDTs) are one of the general approaches for detection of disease ... -
Increasing the affinity between a targeted axonal import (TAxI) peptide and its target receptor hLamR
An efficient delivery approach for trafficking therapeutics into central nervous system (CNS) is a critical unmet need. Previously, we identified a target axonal import (TAxI) peptide that delivers protein cargo into the ...