Browsing Bioengineering by Title
Now showing items 215-234 of 356
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Lipid binding from aqueous solution by lipid conjugated hydroxypropyl methylcellulose (HPMC): a novel food additive for reducing cholesterol and fat intestinal absorption
(1988)This research project focuses on the development and testing of a novel, medically useful lipid or steroid sequesterant that can be administered orally. Specifically, this compound is designed to absorb cholesterol and ... -
Machine Learning Approach to Predict Life-threatening Outcomes with Admit Electrocardiograms of Hospitalized Patients with COVID-19
COVID-19 has been straining the health care systems worldwide due to its high fatality rate and high infection rate. Recent studies found that COVID-19 can cause life-threatening cardiovascular complications in patients. ... -
Macrophage interactions with biomaterial surfaces and their effects on endothelial cell activation
(1998)This research project focused on the development of in vitro models to study cell reactions with material surfaces and how materials exert their influence on cell-cell interactions. Macrophage inflammatory cytokine release ... -
Mapping Visual Receptive Fields in Convolutional Neural Networks
Receptive field (RF) mapping is a fundamental technique for analyzing visual neurons. Neurophysiologists often use simple stimuli such as light spots or bars to locate visual RFs. While this approach is valid for early ... -
Mass Spectral Imaging for Chemical Analysis of Cancerous Tissues Using Time-of-Flight Secondary Ion Mass Spectrometry
Mass spectrometry imaging is unique as it has becoming a versatile and interdisciplinary technique; it openly crosses the boundaries between chemistry and biology as it combines detailed chemical and spatial information ... -
Maturation of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Cardiac tissue engineering enables the generation of functional human cardiac tissue using cells in combination with biocompatible materials. Human pluripotent stem cell (hPSC)-derived cardiomyocytes provide a cell source ... -
Medical ultrasound algorithm for noninvasive high intensity ultrasound applications
(2001)In order to simulate ultrasound propagation and subsequent thermal effects in biological media in which blood vessels and other structures may be present, a 3-dimensional model has been developed that eliminates the need ... -
Megakaryopoiesis, Thrombopoiesis and the Microenvironment
Bone marrow microenvironment has been suggested to be critical for platelet generation. Understanding the environmental cues that regulate megakaryocytes development and platelet production remains a major goal of developmental ... -
Megakaryopoiesis, Thrombopoiesis and the Microenvironment
Bone marrow microenvironment has been suggested to be critical for platelet generation. Understanding the environmental cues that regulate megakaryocytes development and platelet production remains a major goal of developmental ... -
Metabolic Pathway Optimization with Data Driven Approaches
The flux control coefficient (FCC) is a sensitivity coefficient that measures the percent change in flux as a result of a given percentage change in the activity of the enzyme. The higher the FFC the more controlling the ... -
Methods and Applications of Computational Design in Multiple States
The balance between flexibility and stability is a key property of proteins, contributing to the vast area of structures and functions observed in nature. Flexibility arises from the complex energy landscape that determines ... -
Methods and models to control and predict behavior of two dimensional paper networks for diagnostics
Medical care is dramatically more efficient when physicians can diagnose their patient's illness to guide appropriate treatment. Currently, there are two classes of diagnostic tests: high-performance gold standard ... -
Microfluidic Platforms for Focal Stimulation of Muscle Cells and Large-scale Studies of Synaptogenesis
A central question in neurobiology is how the neuromuscular junction (NMJ) forms and maintains its high density of acetylcholine receptors (AChRs) in development. Although many of the molecules involved in NMJ synaptogenesis ... -
Microfluidic platforms for multiplexed functional testing of intact tumor tissues
Despite advances in targeted therapies, cancer treatment continues to face significant challenges as it moves toward the goal of rationally chosen personalized therapy. There is a great need for functional testing platforms ... -
Microfluidic-based Fluorescence Detection for Biomarker Analysis
In this dissertation, 2 platforms are described with the combination of microfluidics and fluorescence detection for biomarker analysis. The first platform described here is to isolate CTCs with high purity by using 2-stage ... -
Microvascular models for cerebral malaria and vascular inflammation
More than 90% of all malaria mortality is from infection with Plasmodium falciparum. Severe cases of P. falciparum infection can progress to cerebral malaria which is characterized by infected red blood cells sequestering ... -
Mobile phone imaging of fluorescence assays in scattering media
Recent efforts to translate diagnostic tests from laboratories to the point of care have yielded countless assays used in clinics and even the home. Point-of-care tests enable earlier diagnosis, potentially improving patient ... -
A model for microcirculatory fluid and solute exchange in the heart
(2002)The exchange of fluids and solutes across the capillary wall is necessary to sustain multicellular life. Although the basic physiology of these processes is understood qualitatively, predicting the detailed kinetics of ... -
Model for Studying the Physiological Role of Non-cell Autonomous Factors on Neuromodulation
The intercellular communication in the ventral horn of the spinal cord is essential for the motor function to innervate skeletal muscle. Hence, the progressive pathologies of several neuromuscular diseases (NMDs) are likely ... -
Modeling Geometric and Hemodynamic Cues in Cardiovascular Biology
From the capillaries to the aorta, the behavior of endothelial cells lining the vasculature is guided by local hemodynamic conditions that can induce both development and disease. Much remains unknown, however, about how ...