Browsing Bioengineering by Title
Now showing items 267-286 of 356
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Patient-Specific Guides: Improved Point-Registration Accuracy for Surgical Navigation and Robotic-Assisted Surgery
Image-based surgical navigation offers improved integration of preoperative planning with intraoperative execution and documentation. Registration is a fundamental step in all surgical navigation procedures and entails the ... -
Peptide-functionalized Biomaterials for Hemostasis and Cancer Imaging
Molecular recognition drives all biological processes and can be leveraged to engineer a broad range of biomaterials for detection and treatment of altered states in the body. Part I of this dissertation focuses on the use ... -
pH-responsive polymers for nucleic acid and vaccine delivery
Biomacromolecules such as nucleic acids and peptides have great potential as therapeutics but must overcome many challenging biological barriers to succeed in the clinic. In this work, we present several investigations of ... -
Phase Sensitive MRI and its Application to Cardiovascular Diseases
Inversion recovery phase sensitive (IRPS) imaging is a T1 weighted magnetic resonance imaging(MRI) method and its T1 contrast is introduced by a $180^{o}$ radio frequency(RF) pulse. IRPS image keeps the polarity map and ... -
Photo-switching of protein activities by conjugation of photo-responsive polymers to proteins
(2001)Photo-switching of protein functions has recently become more actively investigated by many researchers. Our objective is to create novel photo-switchable proteins by conjugating photo-responsive polymers to proteins ... -
Physical and computational methods of investigating the relationship between stress, cognition, and behavior in the context of the KOR-dynorphin system
Motivation: Chronic stress is an aversive experience that can have maladaptive effects on an individual’s cognition and behavior, ultimately leading to increased risk of developing conditions such as anxiety, depression, ... -
Physiological and Mechanical Effects of Prosthetic Elevated Vacuum Systems in People with Transtibial Amputation
A major problem among people with a lower limb amputation is maintaining socket fit. Long-term and short-term changes of residual limb volume can alter socket fit resulting in pain, skin breakdown, or falls. Several ... -
Polymerase Engineering to Expand Access to Nucleic Acid Diagnostics and Technologies
Diagnostic and molecular biology workflows are often complex when first developed, and simplifying them is a key step in expanding their use from high-resource labs to low-resource settings such as clinics and developing ... -
Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
For the treatment of cancer, peptides hold great potential as both targeting and therapeutic agents. One particularly promising anti-cancer strategy is peptides derived from the third Bcl-2 homology domain (BH3), which ... -
Porous membranes for interfacing microfluidics with cell cultures
(2013-11-14)The sensing of chemical gradients plays an important role in the guidance of cells for tissue development, migration of cells in the immune system, and human disease. We have developed a microfluidic transwell insert for ... -
Porous Template Scaffolds as a Three-Dimensional Culture Platform for Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) have been investigated for therapeutic applications due to their regenerative and immunomodulatory properties. While the cells show promise for eventual clinical translation, barriers remain ... -
Predicting expression levels of de novo protein designs in yeast through machine learning.
Protein engineering has unlocked potential for the biomolecular synthesis of amino acid sequences with specified functions. With the many implications in enhancing therapy development, developing accurate functional models ... -
Programming Sequential Reagent Delivering Using a Pseudo-One Dimensional Paper Network
(2013-07-25)Lateral flow tests (LFTs) have been identified as a diagnostic technology well suited for point-of-care use in low resource settings. In addition to being rapid, affordable, disposable, and easy to use, fluid transport of ... -
Quantification of DNA content using 3D Optical Projection Tomographic Microscopy for Early Cancer Diagnosis
(2014-02-24)Aneuploidy, an accepted biomarker for malignancy, is typically assessed by flow (FCM) and image cytometry (ICM). We used optical projection tomographic microscopy (OPTM) for assessing cellular DNA content using different ... -
Quantification of Multimodal Fluorescence Imaging for Cancer Detection, Guiding Biopsy and Guiding Surgery
Fluorescence imaging is emerging for guiding biopsy, early cancer detection and guiding surgery, with the development of new molecularly selective fluorescence agents and fluorescence imaging systems. Accurate quantification ... -
Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology
Optical coherence tomography (OCT) angiography (OCTA) is a recently developed non-invasive functional imaging technique that have been widely utilized in ophthalmology. OCTA is capable of providing three dimensional detailed ... -
Quantitative Computational and Experimental Characterization of Functionalized Nanoparticles
Nanoparticles are widely used in many fields of science and can often be found in everyday commercial products. This widespread use of nanoparticles in our daily lives and the industry have raised several concerns regarding ... -
Quantitative Objective Assessment of Preoperative Warm-up for Robotic Surgery
(2013-11-14)Here I present the application of three established methods for quantitatively and objectively assessing robotic surgical performance as well the development and application of a fourth. These four tools are used to assess ... -
Quantum Dot Platform for Single-Cell Molecular Profiling
(2013-07-23)In-depth understanding of the nature of cell physiology and ability to diagnose and control the progression of pathological processes heavily rely on untangling the complexity of intracellular molecular mechanisms and ... -
Rapidly prototyping complex microfluidics through stereolithography
As organ-on-a-chip research becomes more popular, greater effort is being placed into creating in vitro cell culture systems that more accurately represent the complexity of in vivo biology. Microfluidics, or the manipulation ...