Browsing Bioengineering by Title
Now showing items 321-340 of 356
-
Targeted Nanocarriers for HIV Therapy
Highly active antiretroviral therapy (HAART) can successfully suppress HIV-1 replication in plasma to undetectable levels, but is not capable of eradicating the virus from long-live cellular reservoirs. The latent reservoir ... -
Temperature-dependant [sic] smart bead adhesion: a versatile platform for biomolecular immobilization in microfluidic devices
(2003)Microfluidic systems for chemical and biochemical analysis promise increased process portability, speed, and efficiency as well as decreased waste. One important aspect of microfluidic design is the incorporation of ... -
Tending towards Non-fouling: A study of the interaction between proteins and surfaces prepared by radio frequency glow-discharge plasma
All proteins adsorb irreversibly onto surfaces and often results in denaturation, aggregation and loss of activity. This has serious implications not only for medical devices that are used clinically for the treatment of ... -
The Development, Quantification and Verification of a High-Fidelity Male Urethral Catheter Simulator
Urinary catheter placement is one of the most commonly performed medical procedures in the hospital setting. Many papers present issues with current training tools and educational methods that ultimately may result in ... -
The Endothelium and the Bone Marrow Microenvironment
The bone marrow vasculature provides an interface between the circulation and hematopoietic tissue, allowing for hundreds of billions of blood cells to enter the circulation in an adult human every day. Much is unknown, ... -
The modulation of myosin function: How small molecules and sarcomeric mutations impact actomyosin interactions
The subcellular mechanisms that regulate striated muscle function have been studied by biophysicists and physiologists for over a century. Numerous scientists have made significant findings in the field of muscle biology ... -
The myofilament basis of striated muscle function: Experimental and computational models
For over a century, understanding the subcellular mechanisms that regulate striated muscle function has been of great interest to biophysicists and physiologists. During contraction-relaxation cycles, both skeletal and ... -
The Optimization and Validation of Intranasal GHK-Cu Peptide Drug Delivery in Cognitive Impairment Pathology
Neurological diseases present in 3 individuals out of every 100 over the age of 65. Neurological disorders are characterized by progressive impairment of cognitive function focusing on learning, memory, and decision-making. ... -
The role of metabolism in cardiomyocyte maturation, disease and regeneration
Cardiovascular disease, broadly encompassing both genetic and environmental cardiac pathology, remains the leading cause of death. As such, there is a great need to better model cardiac diseases in an attempt to find novel ... -
The unusual strength of the FimH catch bond under force
Many receptor ligand interactions have developed catch bond properties to overcome and even utilize forces that may oppose the attachment. The lifetime of a catch bond increases under force. FimH is an E. coli adhesive ... -
The Thresholds and Mechanisms of Tissue Injury by Focused Ultrasound
(2014-02-24)Therapeutic ultrasound is used in clinics around the world to treat ailments such as uterine fibroids, kidney stones, and plantar fasciitis. While many of the therapeutic effects of ultrasound are elicited by hyperthermia, ... -
Tissue Engineering Strategies to Improve Post-MI Engraftment of hESC-Derived Cardiomyocytes
Transplantation of stem cell-derived cardiomyocytes is a promising strategy for repairing damaged cardiac muscle following a myocardial infarction. Our group and others have demonstrated both long-term engraftment and ... -
Tissue-Engineered Arterial Tunica Media with Multi-layered, Circumferentially Aligned Smooth Muscle Architecture
Blood vessels play an important role in drug screening in terms of permeability and control of blood flow through cellular responses. Three distinctive functional layers make up the architecture of blood vessels, including ... -
Tissue-Engineered Prostate Cancer Xenografts: A Biomaterials-Based Approach to Study Tumorigenesis and Dormancy Escape
(2014-02-24)Despite massive investments in research and development, it is estimated that 95% of oncology compounds that enter clinical trials ultimately fail to receive FDA approval [1]. This disconnect between pre-clinical testing ... -
Toward a Wholly Organic, Immunomodulatory Neuroelectronic Interface
The neuroelectronic interface is a fascinating and powerful tool for enabling direct electrochemical interaction with the central and peripheral nervous systems as a means to alleviate symptoms of debilitating neurological ... -
Towards a Scalable, Future-Proof Platform for Dynamical Modeling in Biology
Mathematical models are used widely throughout the sciences, and often influence not only research, but our daily lives. For example, weather prediction is made possible by numerical weather models that have advanced ... -
Towards Personalized Cancer Therapy: Microfluidic Approaches for Drug Screening
The ability to predict a patient's response to chemotherapy is a major challenge in oncology. Despite the years of research and development with countless investments, clinical trials in oncology still experience high ... -
Towards Widespread Adoption of Automated Microfluidic Systems
In recent years, sophisticated new microfluidic devices showcasing high degrees of throughput and parallelization have offered great promise towards increasing the speed and efficiency at which research is performed in ... -
Transdural Drug Release for Treatment of Central Nervous System Injury
Traumatic spinal cord and brain injuries may lead to a devastating loss of neurological function. After the traumatic, primary insult, a secondary injury phase ensues, which significantly increases the extent of the injury. ... -
Translational evaluation of electrospun drug delivery systems: fabrication, pharmacokinetics, and tissue-specific host responses
Pre-exposure prophylaxis (PrEP) is an oral regimen of antiretroviral (ARV) drugs for the prevention of HIV. However, near-perfect adherence to PrEP is needed to maintain protective drug concentrations in the lower female ...