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Browsing Bioengineering by Title
Now showing items 149-168 of 356
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Engineering Zwitterionic-switchable Chromatin-mimetic Nanoparticles for Immune Modulation
Currently, one of the major obstacles that impede the wide application of therapeutic protein products is their potential immunogenicity, especially for those obtained from non-human sources. The immune response will ... -
Enhancing CAR T cell safety with new universal CAR systems and anatomically restricted tumor targeting
Chimeric antigen receptor (CAR) T cells are a potent class of immunotherapy that have revolutionized the treatment of hematological malignancies. However, high relapse rates and severe side effects have limited their impact. ... -
Enhancing the performance of silicon photonic biosensors for clinical applications
Silicon photonic biosensors have the potential to transform medical diagnostics and healthcare delivery. Hundreds of these nano-scale sensors can be integrated onto a single millimeter-sized silicon substrate and fabricated ... -
Enzymatically Triggered Delivery of Proteins from Gel Biomaterials using Orthogonal Sortases
Hydrogel biomaterials have proven useful in a variety of medical and basic life science applications, including as platforms for 3D cell culture and controlled drug delivery. User-defined specification over protein ... -
Escherichia coli's literal link to infection: Exploring mutagenesis of the FimH adhesin to allosterically "lock" in low-affinity
(2013-04-17)Expressed by most commensal and uropathogenic <italic>Escherichia coli (E.coli)</italic>, the protein FimH mediates adhesion via catch–bonds to ligand mannose and has become a significant antigen for antiadhesive therapies ... -
Evaluation of a Multivalent Artificial Opsonin to Target and Phagocytose Gram-Negative Bacteria
Hospital-acquired infections (HAIs) are a significant medical concern that must be tackled. HAIs cost the United States billions of dollars annually, and in 2002, were the sixth-leading cause of death [1-2]. Klebsiella ... -
Evaluation of Antibiotic Release from Polymeric Prodrugs
Melioidosis is a bacterial lung infection caused by a pathogen capable of invading alveolar macrophages, where it gains protection from the immune system and antibiotic treatment. These complications necessitate an extensive ... -
Ex Vivo Biomechanical Testing to Examine the Etiology of Low Back Pain as a Result of Whole Body Vibration
(2013-04-17)An association between occupational whole body vibration (WBV) exposure and the development of lower back pain (LBP) has been established through numerous epidemiological studies. However, the etiological and biomechanical ... -
Expanding the capabilities of lateral flow assays using computationally designed affinity proteins
Point-of-care diagnostics have enabled clinical testing in areas previously considered challenging, specifically for underserved populations and in low resource settings. Lateral flow tests, such as the ubiquitous pregnancy ... -
Expanding the Reach of Electrocorticographic Brain-Computer Interfaces: A Bimanual Approach
Brain-computer interface (BCI) technologies have traditionally been designed under the assumption that BCI users are patients who no longer exhibit any significant motor control abilities, due in part to deficits resulting ... -
Exploring heterogeneous phenotypic states in bacteria.
The collective dry biomass of all bacteria on earth is estimated to be in the ballpark of 400 trillion tons. A single human body alone can harbor approximately 100 trillion bacterial cells. We are only just beginning to ... -
Exploring the Molecular Design of Ligand Binding Sites by Computational Protein Design
Ligand binding sites in natural proteins, with diverse structural details, provide the foundation for enzymatic activity, antibody-antigen recognition, ligand-induced pathway activation and drug discovery in general. The ... -
Fabrication and Characterization of an Acellular Human Kidney ECM-derived Hydrogel
Today, more than 900,000 patients in the United States live with end-stage renal disease, with many more suffer from poor renal regeneration1. Current methods commonly use synthetic tissue-engineered constructs to deliver ... -
Fast and Modular Biomolecular Circuits using Spatial Organization
“Biological information processing hubs” ranging from brain to cells to enzyme cascades extensively use spatial organization to process massively parallel molecular instructions and accurately respond to external and ... -
Field-deployable microfluidics for species identification in conservation
This work explores the development of anisotropic ratchet conveyors (ARCs), a type of microfluidic system that can transport small liquid quantities in the form of droplets. ARCs derive their function from a passive, ... -
Field-deployable system for the detection and measurement of micronutrients
Micronutrient deficiency is a global problem affecting billions of people world-wide. A lack in any of vitamin A, zinc, iron, folic acid or iodine can result in major health defects which can greatly reduce quality of life. ... -
Fluorescence anisotropy near-field scanning optical microscopy (FANSOM): a new technique for biological microviscometry
(2001)To test hypotheses regarding putative roles of water structuring in cell function, a near-field scanning optical microscope system was implemented and adapted for nano-scale fluorescence anisotropy measurement. Technical ... -
Fluorescence Detection of DNA Amplification in Porous Media for Point-of-Care Diagnostics
The translation of sophisticated, laboratory-developed methods for disease diagnosis into devices appropriate for locations with limited infrastructure—whether that is a military setting, resource-poor country, or a ... -
Force Generation and Cytoskeletal Structure of Single Platelets
Cardiovascular disease is the most common cause of death worldwide, and one in four deaths is related to dysfunctional blood clotting. Platelet forces are an emerging metric for the balance of clotting and bleeding due to ... -
Functional De Novo Proteins as Custom Molecular Tools for Bioengineering: from Targeted Cancer Immunotherapy to Modular Biosensors
Traditional protein engineering methods use naturally existing proteins as a starting point and are intrinsically limited to small perturbations of a protein’s original structure and function. Computational de novo protein ...