Browsing Bioengineering by Author "Pun, Suzie H"
Now showing items 1-10 of 10
-
Development and Optimization of Peptide-Based, Tumor-Associated Macrophage (TAM)-Targeting Therapeutics
Ngambenjawong, ChayanonCancer is one of the leading causes of death and is a subject of intense research worldwide. Within the past few decades, cancer immunotherapy has emerged as an important arm of cancer therapies following the prominent ... -
Development of Biomaterials for Chimeric Antigen Receptor (CAR) T Cell Therapy
Olden, BrynnChimeric antigen receptor (CAR) T cell therapy has emerged as an effective new cancer treatment that genetically reprograms a patient’s T cells to recognize an epitope specifically expressed on the surface of cancer cells ... -
Development of Peptide-Polymers for Drug and Gene Delivery to the Central Nervous System
Chu, David Sai-HoDiseases of the central nervous system are largely untreatable, with most current treatment strategies palliative. Current therapeutic strategies are limited by drugs of low potency, poor pharmacokinetics, and poor ... -
Engineering and Evaluating Fibrin-Targeted Biomaterials for Hemostasis
Lamm, Robert JamesTraumatic injury incurs a heavy burden on both civilian and military populations throughout the world, and a large proportion of these deaths are due to hemorrhage, or uncontrolled bleeding. Current interventions are not ... -
Engineering multiscale therapeutics for kidney disease
Liu, GaryNew therapies are urgently needed to address the growing chronic kidney disease epidemic. Nanoscale materials can enable precision drug delivery to kidney cells, improving the efficacy and safety profile of drug cargo. ... -
Engineering Nanomaterials to Overcome Barriers in Cancer Therapy
Wang, Christine ErlineCytotoxic chemotherapy is used for the frontline treatment of most types of cancer but is associated with significant toxicity due to the lack of cell specificity of these drugs. Newer treatment strategies, such as polymeric ... -
Identification and Characterization of M2 Macrophage-targeting Peptide M2pep for the Delivery of Pro-apoptotic Peptides to Tumor-associated Macrophages
Cieslewicz, Mary E.Activated macrophages are made up of two broad subsets, M1 “classically activated” macrophages and the M2 “alternatively activated” macrophages. These subsets present diverse functional phenotypes, with M1 macrophages ... -
Investigating the Intracellular Trafficking of Polymeric Vectors for Gene Delivery
Shi, Julie (2013-11-14)Gene therapy has the potential to revolutionize the treatment of diseases caused by genetic mutations. The development of effective, biocompatible synthetic gene delivery vectors can be improved by understanding the ... -
Peptide-functionalized Biomaterials for Hemostasis and Cancer Imaging
Chan, Leslie Wan-GeeMolecular recognition drives all biological processes and can be leveraged to engineer a broad range of biomaterials for detection and treatment of altered states in the body. Part I of this dissertation focuses on the use ... -
Synthetic Polymer and Microbubble Systems for Gene Delivery to the Brain
Tan, James-Kevin YoungThe natural neurogenesis after neuron death in cases like traumatic brain injury and neurological diseases is sparse. Increasing the replenishment of functional neurons can improve patient outcome and prognosis. One way ...