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Browsing Bioengineering by Subject "Nanotechnology"
Now showing items 1-13 of 13
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A Nanopatterned Cantilever Device for Assaying Contractile Properties of Stem Cell-Derived Cardiomyocytes
Drug-induced cardiotoxicity has been a major issue for both patients and pharmaceutical companies. Current in vitro cardiotoxicity screening utilizes genetically modified cell lines, which do not recapitulate adult human ... -
Combinatorial maturation strategy for disease modeling and phenotypic drug screening of Duchenne muscular dystrophy cardiomyopathy
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer great promise for regenerative medicine, preclinical drug screening, and cardiac disease modeling applications. One of the most significant hurdles towards ... -
Development of Peptide-Polymers for Drug and Gene Delivery to the Central Nervous System
Diseases of the central nervous system are largely untreatable, with most current treatment strategies palliative. Current therapeutic strategies are limited by drugs of low potency, poor pharmacokinetics, and poor ... -
Engineering multiscale therapeutics for kidney disease
New therapies are urgently needed to address the growing chronic kidney disease epidemic. Nanoscale materials can enable precision drug delivery to kidney cells, improving the efficacy and safety profile of drug cargo. ... -
Engineering polymeric biomaterials to treat kidney diseases and leverage boronic acid chemistry for drug delivery
Polymer drug delivery vehicles are diverse and powerful tools to modulate biodistrubution, cellular uptake, and dosing of therapeutics. As our understanding of the biological barriers improves, the challenges facing the ... -
Fast and Modular Biomolecular Circuits using Spatial Organization
“Biological information processing hubs” ranging from brain to cells to enzyme cascades extensively use spatial organization to process massively parallel molecular instructions and accurately respond to external and ... -
Immunoengineering nanoparticles for mucosal drug and vaccine treatment of sexually transmitted infections
Sexually transmitted infections (STIs) are a major burden on human health worldwide, accounting for nearly 1 million infections daily. Women’s sexual and reproductive health is disproportionately impacted by the most ... -
Immunofluorescence of Intracellular Targets in Live Cells
Every second, living human cells are executing complex functions to initiate or influence various processes such as energy production, growth, metabolism and reproduction. This also means that intracellular structures are ... -
Insights of Mixing on the Assembly of DNA Nanoparticles
(2013-07-25)Size is a crucial parameter in the delivery of nanoparticle therapeutics, affecting mechanisms such as tissue delivery, clearance, and cellular uptake. The morphology of nanoparticles is dependent both upon chemistry and ... -
Multiscale Tunable Hybrid Biomaterials for Engineering Human iPSC-Based Cardiac Microphysiological Systems
Human induced pluripotent stem cells (hiPSCs) offer tremendous potential for use in engineering human tissues for disease modeling, drug development, and cell therapy. However, differentiated cardiomyocytes are phenotypically ... -
Nanomaterial Strategies to Enhance Antiretroviral Efficacy for Vaginal Drug Delivery
HIV continues to infect millions of people worldwide, and without an effective vaccine or cure available, there is need for new methods to prevent infection. Women are disproportionately impacted by HIV due to biologic ... -
Quantum Dot Platform for Single-Cell Molecular Profiling
(2013-07-23)In-depth understanding of the nature of cell physiology and ability to diagnose and control the progression of pathological processes heavily rely on untangling the complexity of intracellular molecular mechanisms and ... -
Repurposing DNA for information processing and storage
DNA is the principal carrier of biological information. It is present in nearly all forms of life and it enables the transfer of genetic information between many generations. Beyond its natural role, DNA is also a programmable ...