Browsing Bioengineering by Subject "Biomedical engineering"
Now showing items 1-20 of 166
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A Computational Tool to Enhance Clinical Selection of Prosthetic Liners for People with Lower Limb Amputation
People with transtibial amputation experience a loss of mobility that results from the removal of propulsive and load bearing anatomy. The more delicate soft tissues of the residual limb are coupled to a hard prosthetic ... -
A Nanopatterned Cantilever Device for Assaying Contractile Properties of Stem Cell-Derived Cardiomyocytes
Drug-induced cardiotoxicity has been a major issue for both patients and pharmaceutical companies. Current in vitro cardiotoxicity screening utilizes genetically modified cell lines, which do not recapitulate adult human ... -
A Thermoresponsive Magnetic Nanoparticle System Using an Antiviral Lectin for HIV Capture and Concentration
Rapid tests have been developed as a method to diagnose HIV infection in resource-limited settings. However, several of these assays suffer from reduced sensitivity due to the limited sample volume. One approach to augment ... -
Ambulatory Vascular Monitoring for Quantication of Lower Leg Hemodynamics and Severity of Venous Disease
Persons with chronic venous disease experience progressive deterioration of their lower extremity hemodynamics. Different factors are thought to contribute to this hemodynamic decline, including incompetent venous valves, ... -
Analysis of the Ventricular Fibrillation Electrocardiogram During Cardiopulmonary Resuscitation to Predict Outcome of Out-of-Hospital Cardiac Arrest
Out-of-hospital ventricular fibrillation (VF) cardiac arrest results in approximately 50,000 deaths per year in the United States. Treatment includes defibrillation shock supported by cardiopulmonary resuscitation (CPR). ... -
Atherosclerosis Plaque Neovascular Inflation Using Ultrasound Strain Imaging
Vasa vasorum (VV) are small arterial and venous networks that originate from major arteries and drain into major veins; penetrating into the arterial wall to supply oxygen and nutrition for the tissues on the outer layer ... -
Bioengineering New Therapeutics for Pulmonary Infections
Pulmonary intracellular infections including tuberculosis, legionellosis, tularemia, and melioidosis present serious global health threats. Those intracellular infections, localized to the lung alveolar macrophage (AM), ... -
Bioimpedance Analysis to Determine the Effect of Pressure Release on Limb Fluid Volume Change in Persons with Transtibial Limb Loss
(2012-09-13)INTRODUCTION: Over 1 million Americans currently live with a lower limb amputation. Lower limb prostheses have been designed to produce a secure and comfortable fit between residual limb and prosthesis throughout the day. ... -
Biological Probes to Measure Transcription Dynamics in E. coli
RNA molecules exhibit dynamic behaviors that are critical to maintaining normal cell function, and their dynamic nature has been exploited to engineer biological systems. RNA dynamics processes that are often investigated ... -
Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
(2013-11-14)Nanoparticles are emerging as versatile vehicles for drug delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) ... -
Biosensor Platform Development for Studying Carbohydrate-Mediated Bacterial Adhesion
(2013-02-25)Infectious diseases are the second leading cause of mortality worldwide, accounting for 14.9 million deaths each year. Diarrheal diseases, usually a result of infection by enteric pathogens, cause 1.8 million of these ... -
Cavitation monitoring and spatial mapping for pulsed high-intensity focused ultrasound enhanced drug delivery
High intensity focused ultrasound (HIFU) is an emerging non-invasive ablation modality, in which high amplitude ultrasound waves are focused inside the human body to thermally ablate or mechanically disrupt the tissue at ... -
Characterization and Computational Evaluation of a Genetically Encoded Fluorescent Probe for Reactive Oxygen Species
Reactive Oxygen Species (ROS) are highly reactive chemical molecules that have essential roles in physiological processes. H2O2 is a relatively stable member of ROS family in aqueous environment and serves as an important ... -
Characterization of Ultrasound Pressure Fields, Microbubbles and Their Interaction
Ultrasound’s therapeutic applications are increasing daily, and have spread in different medical fields, such as cardiology, sports medicine, urology, oncology, and even the field of cosmetics. Focused ultrasound (FUS) has ... -
Chemical Modification of Cellulose for Biomolecule Capture
(2012-09-13)Paper-based analytical devices are the subject of growing interest for the development of low-cost point-of-care diagnostics, environmental monitoring technologies, and research tools for limited-resource settings. However, ... -
Closed-Loop Neural Engineering Approaches to Motor Rehabilitation
Here I present several approaches to applying engineering design principles to the central nervous system with the goal of using closed-loop approaches to enhance rehabilitative processes. These approaches cover invasive ... -
Combinatorial maturation strategy for disease modeling and phenotypic drug screening of Duchenne muscular dystrophy cardiomyopathy
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer great promise for regenerative medicine, preclinical drug screening, and cardiac disease modeling applications. One of the most significant hurdles towards ... -
Comparing the release rates of ciprofloxacin from different polymer structures with different linker chemistries
Polymeric prodrugs of ciprofloxacin for inhalation are attractive alternatives to orally-administered free ciprofloxacin and inhalable liposomal formulations. This study investigated the release kinetics of ciprofloxacin ... -
Comprehensive automated analysis of three-dimensional brain cell-resolution imaging data
Neuroimaging techniques provide immensely valuable data for medical professionals and academic researchers alike, but analysis of these data is difficult and often relies on subjective interpretations. This project proposes ... -
Computational design and optimization of protein-protein interactions to engineer novel binders of Influenza Hemagglutinin
Influenza is a serious public health concern and new therapeutics that protect against this highly adaptable virus are urgently needed. For this dissertation my efforts were focused on creating and improving de novo designed ...