Browsing Bioengineering by Author "Yager, Paul"
Now showing items 1-12 of 12
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An integrated system for large volume sample processing at the point of care
Byrnes, Samantha AnnThe emergence of rapid, user-friendly, point-of-care (POC) diagnostic systems is paving the way for better disease diagnosis and control. Lately, there has been a strong emphasis on developing molecular-based systems due ... -
Development of a Highly Sensitive Protein Diagnostic Device using Isothermal Strand Displacement Amplification
Guelig, DylanThe lateral flow test (LFT) is the preferred tool for detection of protein biomarkers in low-resource settings. While low-cost and rapid, these immunoassay devices often suffer from limited sensitivity in the single chemical ... -
Development of a Novel Paper-Based Flu Test for Improved Diagnosis at the Point of Care
Holstein, Carly AnnThe development of paper-based diagnostics has surged in recent years, due to the suitability of these tests for use at the point of care. Paper-based diagnostics offer the ability to perform relatively sophisticated ... -
Expanding the capabilities of lateral flow assays using computationally designed affinity proteins
Anderson, Caitlin EPoint-of-care diagnostics have enabled clinical testing in areas previously considered challenging, specifically for underserved populations and in low resource settings. Lateral flow tests, such as the ubiquitous pregnancy ... -
Fluorescence Detection of DNA Amplification in Porous Media for Point-of-Care Diagnostics
Monahan, Caitlin MalloryThe translation of sophisticated, laboratory-developed methods for disease diagnosis into devices appropriate for locations with limited infrastructure—whether that is a military setting, resource-poor country, or a ... -
Heat, Fluid, and Sample Control in Point-of-Care Diagnostics
Buser, Joshua R.Point-of-care diagnostics have transformed healthcare workflow, perhaps most notably in the wide-reaching impact of home pregnancy tests. Lateral flow strips are simple and inexpensive, but limited in their application to ... -
Increased sensitivity for lateral flow immunoassays through signal amplification methods
Abe, KojiThe simple and inexpensive sandwich-immunoassay-based lateral flow tests (LFTs, also known as lateral flow immunoassays, LFIAs, and rapid diagnostic tests, RDTs) are one of the general approaches for detection of disease ... -
Insights of Mixing on the Assembly of DNA Nanoparticles
Williams, Manda (2013-07-25)Size is a crucial parameter in the delivery of nanoparticle therapeutics, affecting mechanisms such as tissue delivery, clearance, and cellular uptake. The morphology of nanoparticles is dependent both upon chemistry and ... -
Methods and models to control and predict behavior of two dimensional paper networks for diagnostics
Fridley, Gina EllaMedical care is dramatically more efficient when physicians can diagnose their patient's illness to guide appropriate treatment. Currently, there are two classes of diagnostic tests: high-performance gold standard ... -
Mobile phone imaging of fluorescence assays in scattering media
Shah, KamalRecent efforts to translate diagnostic tests from laboratories to the point of care have yielded countless assays used in clinics and even the home. Point-of-care tests enable earlier diagnosis, potentially improving patient ... -
Real-time Three-Dimensional DNA Microarrays: How Well Can We Distinguish Between Related Target Sequences?
Lemba, Maris (2013-04-17)DNA microarrays, due to their highly parallel nature, are in principle well suited for rapid identification of known or related microbial species, but our ability to extract meaningful information from microarray images ... -
The Development, Quantification and Verification of a High-Fidelity Male Urethral Catheter Simulator
Schul, Alyssa LouiseUrinary catheter placement is one of the most commonly performed medical procedures in the hospital setting. Many papers present issues with current training tools and educational methods that ultimately may result in ...