Now showing items 1-1 of 1
Identifying substrate and E2 interactions of the BRCA1/BARD1 ubiquitin ligase
My thesis project addresses the need to understand the function of the Breast Cancer Susceptibility Protein, BRCA1, during the process of protein ubiquitination. A significant number of known cancer predisposing mutations are found within BRCA1's RING domain which, when associated with BARD1, functions as a ubiquitin ligase. ...