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Structural Studies of RNF146-Mediated PARylation-Dependent Ubiquitylation
The ubiquitylation of proteins is involved in nearly every cellular process. Hence, precise control of the ligases that facilitate the attachment ubiquitin (Ub) to target substrates is of the utmost importance to eukaryotic biology. My thesis work on the RING E3 ubiquitin ligase RNF146 has defined a new mechanism by which a ...