The Notch receptor of Drosophila and its homologues in other organisms mediate cell-cell interactions required for the correct partitioning of cell fates within equivalence groups. Genes related to Notch and other components of the Notch signaling pathway represent a well conserved system for signal transduction, having been ...

Experiments early in this century indicated that dorsoventral axis formation in the Xenopus embryo requires the activity of the Spemann organizer, or gastrula organizer. Cell and cytoplasmic transplantation studies subsequently defined the earlier acting blastula organizer, or Nieuwkoop center, which induces formation of the ...

Nuclear magnetic resonance spectroscopy was used to study the DNA-binding domain of yeast transcription factor ADR1. A polypeptide containing the minimal DNA-binding region was overexpressed in E. coli and purified to homogeneity. The construct, ADR1z, contains two Cys$\sb2$-His$\sb2$ zinc fingers and an N-terminal sequence ...

The mitogen activated protein kinase (MAP kinase) cascade has emerged as an evolutionarily conserved element in the transduction of a wide variety of extracellular signals. In mammals, at least three distinct pathways have been identified. These include ERKs, activated by growth factors and other mitogenic stimuli; JNKs, ...