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Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions
Proteins possess huge potential as therapeutic agents for the control and modulation of human physiology. Protein interactions regulate most physiological processes, mediating the connection between atomic-scale self-assembly and macroscale health and disease. Natural proteins often display exquisite specificity and high ...
Protein Structure Determination from Cryo-electron Microscopy Density Maps
Single-particle cryo-electron microscopy (cryo-EM) has emerged as a powerful tool in structure determination of macromolecular complexes that are not suitable for crystallographic studies. Recent advances in direct electron detectors and image-processing techniques have allowed cryo-EM to reach near-atomic resolution (3–5 Å) ...