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The conserved coiled-coil protein CCCP1 and the endosomal complex EARP regulate dense-core vesicle cargo sorting
The regulated release of peptide hormones (e.g. insulin), neuropeptides, and monoamines depends on their being packaged into dense-core vesicles (DCVs). How these vesicles are made and how their cargo is properly selected is not well understood, especially at the molecular level. DCVs are generated at the trans-Golgi network ...