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Innate and humoral immune responses to HIV-1
(2014-02-24)
Understanding cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to HIV-1 infection and vaccination ...
Assessing and Improving Computational Models of Protein Thermodynamics and Kinetics
(2013-04-17)
The purpose of this thesis is to rigorously assess and improve computational models of protein thermodynamics and kinetics. The first part consists of computational ddG prediction; we explore the performance of protocols which sample an increasing diversity of conformations and examine their abilities to recapitulate both ...
Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions
(2014-04-30)
Proteins possess huge potential as therapeutic agents for the control and modulation of human physiology. Protein interactions regulate most physiological processes, mediating the connection between atomic-scale self-assembly and macroscale health and disease. Natural proteins often display exquisite specificity and high ...
Biophysical mechanisms of the kinetochore-microtubule interface and its regulation during mitosis
Chromosomes carry the genetic information that acts as a "blueprint" for every organism. When cells divide, replicated copies of the chromosomes are segregated into two new cells that are genetic copies of the original. This process is mediated by the mitotic spindle, a bipolar array of dynamic microtubules that connect to ...
Structural and Functional Characterization of Non-Canonical Ubiquitin Conjugating Enzymes
Thirty-five years ago, during its initial discovery, the field of ubiquitination could not have been more aptly named. In fact, as the study of ubiquitin (Ub) expands, it is becoming clear that this small post-translational modification is far more ubiquitous than the founders of this field could have originally imagined. ...