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The Role of A-type Lamins in Normal Cardiac Function
A-type lamins, primarily represented by the proteins lamin A and lamin C, are unique intermediate filaments that localize to the inner nuclear membrane to form the nuclear lamina. The lamina helps maintain nuclear structure in addition to having regulatory roles in a range of nuclear processes. Point mutations in lamin A have ...
Roles of the HOPS complex and Sec1/Munc18 proteins in membrane fusion
A fundamental feature of the eukaryotic cell is its diversity of membrane bound compartments. Despite a constant flux of proteins and lipids through these compartments, organelle identity and function is maintained by regulating membrane fusion. Membrane fusion is driven by the coordinated action of a several families of ...