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Innate and humoral immune responses to HIV-1
(2014-02-24)
Understanding cellular and humoral immune responses to HIV-1 infection and designed HIV immunogens are imperative to the development of an effective anti-HIV vaccine. In this thesis we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to HIV-1 infection and vaccination ...
Exploring Epitope-Focused Vaccine Development: Design of Epitope Scaffolds and Nanoparticle Presentation Platforms, and Computational Prediction of Conformational Epitopes
(2014-02-24)
Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) evolved a number of defense strategies to evade protective mechanisms of the immune system. Classical vaccine approaches have failed to elicit a protective response for these targets. Epitope Scaffolding is a theoretically attractive immunogen design strategy, ...
Computational Design of Protein Therapeutics with Reduced Immunogenicity through Structural Modeling of Protein Interactions
(2014-04-30)
Proteins possess huge potential as therapeutic agents for the control and modulation of human physiology. Protein interactions regulate most physiological processes, mediating the connection between atomic-scale self-assembly and macroscale health and disease. Natural proteins often display exquisite specificity and high ...
Kinetochore-microtubule coupling and its regulation during mitosis
(2014-04-30)
The coupling of kinetochores to dynamic spindle microtubules is crucial for chromosome positioning and segregation, error correction, and cell cycle progression. This linkage depends on the Ndc80 complex, a conserved and essential microtubule-binding component of the kinetochore. As a member of the complex, the Ndc80 protein ...
Understanding and Manipulating Anti-HIV Antibody Responses via Structural Methods
(2014-02-24)
Anti-HIV antibody responses offer one of very few potential routes towards a protective HIV vaccine; structural biochemistry methods such as crystallography and computational modeling can provide key insights for the design of candidate vaccine components and enhance the evaluation of complex experimental outcomes. Accordingly, ...