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Structural and biochemical studies of protein poly(ADP-ribosyl)ation
Protein poly(ADP-ribosyl)ation (PARylation) has been found to be involved in various cellular processes, such as DNA damage recognition and repair, chromatin structure dynamics, gene transcription and poly(ADP-ribose)-dependent cell death. Most recently, PARylation has been shown to control the polyubiquitination and degradation ...
An ancient neurotrophin code in zebrafish; the Runx/Cbfβ complex specifies the fate switch from TrkB+ to TrkC+ nociceptors and sensory receptor expression
The somatosensory system is a critical interface to the environment. It contains a highly diverse group of sensory neurons that are responsible for sensing touch, temperature, pain, and proprioception. The Runx transcription factors have been identified as key factors in generating some somatosensory neuron diversity. However, ...