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Defining the cis-acting requirements in the HMG-CoA reductase gene for karmellae biogenesis
In yeast and mammalian cells, increased levels of the ER membrane protein, HMG-CoA reductase (HMGR), induce specific ER membrane arrays. Yeast express two HMGR isozymes, Hmg1p and Hmg2p, each of which induces a morphologically distinct proliferation of the ER. Hmg2p induces short stacks of ER membranes that may be found ...