The population attributable fraction (PAF) is an important measure in evaluating the contribution of risk factors to disease burden or mortality. It is a useful tool for planning of prevention actions. Recent development ...

Identity-by-descent (IBD) is defined as two individuals sharing a haplotype they have both inherited from a common ancestor, where a haplotype is a segment of genetic material found on a single homologue. Existing methods ...

This study was a secondary analysis of data from a study investigating the association between inflammatory bowel syndrome (IBS) and nocturnal cortisol and catecholamines in a sample of IBS subjects and healthy controls. ...

Sequential safety monitoring of newly-licensed vaccines is a national health priority and is routinely conducted using observational data. However, applying sequential methods in observational settings where the adverse ...

Smoking as an epidemiological exposure can be quantified in terms of duration, intensity, pack-years, recency, and time of life. It is not clear which of these are important for cardiovascular disease, and how they should ...

In this dissertation, we set out to develop new methods for the analysis of time-to-event data. In particular, we are concerned with residual time, or the time remaining to an event after a certain amount of time has passed ...

Fluorescence image cytometry is a common laboratory method used to analyze tissue and culture specimens at the cellular level. Fluorescence imaging is useful because fluorescent stains are highly specific and imaging allows ...

Many common diseases that potentially have a large public health impact, such heart disease, cancer, and diabetes, are known or thought to have a genetic component to risk. These traits are often complex with multiple ...

Cost data are being collected more frequently in randomized clinical trials in order to assess the cost-effectiveness of experimental treatments. As such, the goal of this dissertation is to study three separate topics ...

Recent emergence of the common disease-rare variant hypothesis has renewed interest in the use of large pedigrees for identifying rare causal variants. Genotyping of dense variants using technologies that include next-generation ...