Browsing Chemical engineering by Author "Jiang, Shaoyi"
Now showing items 1-20 of 24
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A Study of Zwitterionic Polypeptide-Protein Conjugates
Niu, LiqianProtein therapeutics has been an attractive approach to serve patients. However, the safety and efficacy of these products are limited by their immunogenicity, low circulation time, and instability. Conjugation is one of ... -
Biocompatible zwitterionic polymer chemistries and hydrogels for gene therapy, drug delivery, and regenerative medicine
Sinclair, Andrew WilliamZwitterionic polymers have recently gained significant attention as a unique class of biomaterials, with their superhydrophilicity and unrivaled biocompatibility setting them apart from non-ionic and single-charged polymers. ... -
Bioinspired Anti-fouling Coating on Hydrophobic Surfaces
Che, XinranAnti-biofouling is very important in many applications ranging from marine coatings to biomedical devices. The poor bio-compatibility of medical devices with human body causes undesired effects. Therefore, to achieve ... -
Coupling molecular dynamics and machine learning to accelerate the design of bioinspired materials
Smith, Joshua KenyonBiological systems, including the human body, are directed by networks of exquisitely selective chemical interactions. Following the paradigm of bioinspired materials design, scientists and engineers aim to understand the ... -
Developing Low Fouling Peptides and Zwitterionic Materials for Biomedical Applications
Nowinski, Ann KateThis dissertation is a compilation of efforts aimed at developing mixed charge and zwitterionic materials to prevent biofouling in biomedical applications. Peptides are considered for use as natural low fouling materials ... -
Developing Multifunctional Surface Chemistry for Plasmonic Biosensing in Complex Media
Sun, FangDuring the past decades, plasmonic sensors have been explored extensively due to their ultra-sensitivity and emerged as a new generation of analytical tools. Two of the most widely used and studied plasmonic sensors are ... -
Developing Nonfouling Zwitterionic Coating for Biomedical Applications
Wu, KanDuring the past decades, the demand for biomaterials with good biocompatibility is increasing with the rapid development of advanced medical technologies, such as biosensors, implantable chips, hemodialysis and biopharmaceutical ... -
Developing Zwitterionic Hydrogel for Biomedical Applications
Bai, TaoUltra-low fouling zwitterionic hydrogels offer unique advantages over conventional biomaterials in biomedical applications. By exclusively using zwitterionic monomer and crosslinker, pure zwitterionic hydrogels can be ... -
Development of a High-Strength Zwitterionic Hydrogel to Combat Biofouling in Marine and Medical Applications
MacArthur, JoelBiofouling is a phenomenon that targets nonnative objects in biological settings, which has detrimental economic effects on global industry, notably those operating in marine or medical environments. In our efforts to ... -
Development of Mixed-Charge EK Polypeptides for Protein Protection
Liu, Erik JerryThe presented work focuses on the development of mixed charge polypeptides and their fusion proteins and protein conjugates for the protection of proteins. Compared to many polymers used to modify proteins, polypeptides ... -
Discovery and Development of Synthetic and Natural Biomaterials for Protein Therapeutics and Medical Device Applications
Keefe, Andrew (2013-11-14)Controlling nonspecific protein interactions is important for applications from medical devices to protein therapeutics. The presented work is a compilation of efforts aimed at using zwitterionic (ionic yet charge neutral) ... -
Environmentally friendly self-polishing anti-fouling coatings for marine applications
Xue, JiaweiMarine environment is highly prone to fouling for all water-immersed surfaces. This causes huge burden on marine vessels and structures. Environmental friendly coatings are highly desirable to replace existing toxic coatings. ... -
Hunt for a Genetically Engineered, Rationally Designed, Stealth Peptide to Prevent Non-Specific Protein Interactions
Corrigan, TrevorThe objective of this study is to identify the best zwitterionic peptide as a tail of a fusion protein to preserve protein stability and bioactivity without immunogenicity. Two major strategies currently available to ... -
Improving Safety and Efficacy of Protein Therapeutics by Chemical Modifications
Zhang, PengProtein therapeutics offer the advantages of high specificity and potency. However, their applications are greatly limited due to undesired immune responses, which not only reduce their therapeutic efficacy, but also cause ... -
Mixed-charge copolymer as environmentally friendly low fouling marine coatings
Ai, Jia-RueySelf-polishing marine coatings made of mixed charged and other hydrophobic methacrylates are developed via free radical polymerization. By introducing the mixed-charge structure into the copolymer system, the marine coatings ... -
Modeling Nonspecific Interactions at Biological Interfaces
White, Andrew David (2013-07-25)Difficulties in applied biomaterials often arise from the complexities of interactions in biological environments. These interactions can be broadly broken into two categories: those which are important to function (strong ... -
Molecular Engineering Approaches against Germs, Spores and Biofilm Formation
Mi, LuoBacterial surface adhesion, colonization and related infections have been major issues plaguing many industrial and biomedical applications. In fact, the very subject has posed engineering challenges and incented scientific ... -
Multifunctional Zwitterionic Surface Chemistry for Applications in Complex Media
Brault, Norman D (2014-04-30)The realization of personalized medicine relies on the discovery of clinically relevant biomarkers as well as on the development of corresponding assays. Due to the complexity of human blood plasma and serum, the most ... -
Study of a Novel Zwitterionic Material and Its Biological Applications
Ma, JinrongZwitterionic materials have been demonstrated to have excellent non-fouling properties for a wide range of biomedical and engineering applications. Inspired by naturally occurring osmolytes, our group have developed new ... -
Understanding Properties of Zwitterionic Materials from Their Molecular Structures
Shao, Qing (2014-04-30)Materials that resist nonspecific protein adsorption in complex media are important for many biological and chemical applications, such as surface coatings of biosensors, marine coatings, drug delivery, and therapeutic ...