Chemistry
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Hydroalkylation of Alkynes via Dual Copper-Nickel Catalysis
Chapter 1 describes the stereospecific synthesis of E-alkenes through a dual copper and nickel catalysis system involving terminal alkynes and primary and secondary alkyl iodides. This reaction proceeds with excellent ... -
Advancements in Single Molecule Localization Microscopy for Improved Multichannel, 3-Dimensional, and Structurally-Dense Imaging
Super-resolution fluorescence microscopy now enables cellular detail to be probed at the nanometer scale using far-field optics with widely available instrumentation. However, single molecule localization microscopy (SMLM) ... -
Dissecting Mechanisms of Antimalarials using CRISPR/Cas9 Editing in Plasmodium falciparum
Malaria, caused by Plasmodium infections, continues to be a global disease of public health importance with 300 million annual cases and about 500,000 deaths. Continual emergence of resistance to commonly used antimalarials ... -
Leveraging Operando Characterization Methods to Reveal Failure and Optimization Mechanisms of Group IV Semiconductor Battery Anodes
Expanding the application space of lithium battery technology will require electrode materials that exhibit performance metrics which outperform their modern counterparts. The availability of prospective next-generation ... -
Cross Coupling of Alkenyl Gold Complexes with Alkyl Electrophiles and Nickel Catalyzed Hydroarylation of Alkenes
Transition metal catalysis is a powerful strategy for the construction of organic molecules. The development of novel methods in this field can help improve the speed and efficiency with which we synthesize complex organic ... -
Modeling Nanomaterials with Efficient and Accurate Electronic Structure Methods
Electronic structure methods are one of the most powerful tools in the computational toolbox to provide an atomistic understanding of molecules and materials. Among all electronic structure methods, Density functional ... -
Novel Mass Spectroscopy Techniques Implementing UV Action Spectroscopy for the Characterization of DNA Cation Radicals and Transition Metal Complexes
Mass spectrometry has become a powerful analytical tool for the detection and characterization of chemical compounds for biological and environmental studies. Advancements in mass spectrometry including new ionization ... -
Partial Modulation Injection for Gas Chromatography
Partial modulation is developed and refined for one-dimensional gas chromatography (1D-GC), comprehensive two-dimensional gas chromatography (GCÃ GC), and comprehensive three-dimensional gas chromatography (GC3). Since ... -
Chemical Approaches to Study the Effect of Histone Post-translational Modifications
Genetic material is stored in a massive nucleoprotein complex called Chromatin. The basic unit of Chromatin is the Nucleosome Core Particle or NCP, made up of 147 bp DNA wound around a core of histone protein octamer ... -
Synthesis of colloidal semiconductor heterostructures for photocatalysis
The development of colloidal nanoscale semiconductors for next-generation technologies is attractive due to their size-dependent optoelectronic properties and compatibility with solution-based manufacturing methods. This ... -
Probing Electrochemical Processes of Single Entities at the Electrode/Solution Interface
This dissertation presents the development and application of new experimental tools and methods for studying single-entity (such as nanoparticles, molecules, and nanobubbles) electrochemistry. Compared to traditional ... -
Lewis Acid Passivation of Mechanically Exfoliated Black Phosphorus
Exfoliated black phosphorus (exf-BP) is a 2D material with a tunable bandgap and favorable electron transport properties for optoelectronic applications. However, its instability under ambient conditions presents challenges ... -
Pharmacological Modulation and Functional Characterization of the Protein Kinase-Endoribonuclease IRE1α
Faithful folding of proteins in the endoplasmic reticulum (ER) is essential for cell survival and proper cellular function. Understandably, unfolded or misfolded proteins contribute to a myriad of human diseases. Numerous ... -
Computational Modeling of Dynamic Electron Paramagnetic Resonance Spectra
A comprehensive method is laid out for the solution of the stochastic Liouville equation to simulate spectral lineshapes for continuous-wave EPR spectra. The method is presented in a general fashion so that the same ... -
Electrochemical Characterization of Nanomaterials and Development of New Electrochemical Methods
This dissertation focuses on studying fundamental properties of nanomaterials with electrochemical methods and the development of new electrochemical methods to study single nanoparticles and vesicles. Chapter 1 introduces ... -
Characterization of Trp-Cage and Its Circular Permutation
The relationship between sequence, the folded structure, and the folding pathway by which that structure is reached presents a topic of tremendous importance in the understanding of proteins. However, the study of most ... -
Using Molecular Dynamics Simulations and Statistical Modeling to Explore Membrane Structure and Membrane-Protein Interactions
The structure of cellular membranes gives rise to important biological phenomena, and understanding the (de)mixing behavior of multicomponent lipid bilayers is an important step toward unraveling the nature of spatial ... -
A high-throughput screening assay based on TR-FRET to identify inhibitors for T. brucei kinases
African Sleeping Sickness or Human African Trypanosomiasis (HAT) is one of the most under studied tropical diseases and continues to be a threat to more than 65 million people in sub-Saharan Africa. It is caused by the ... -
Molecular Composition, Volatility, and Formation Mechanisms of Biogenic Secondary Organic Aerosol
The research herein seeks to answer the following question: what are the main processes governing the formation and properties of secondary organic aerosol (SOA) from oxidation of biogenic volatile organic compounds (BVOC) ... -
Chemical strategies for investigation of deubiquitinases
Regulation of protein structure and function by post-translational modification is a key mechanism in cellular homeostasis. Among known modifications the small protein ubiquitin is unique in the breadth of functions it ...
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