Chemistry
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Dissection of spatiotemporal intracellular signaling using engineered chemical and genetic tools
Cellular signaling proteins are responsible for transmitting intracellular signals and enacting the appropriate response to received stimuli. These messages are propagated through networks that rely on allosteric regulation, ... -
Aminophosphines as Precursors for Doped and Phase Pure Metal Phosphide Nanocrystals: Synthesis Beyond P(SiMe3)3
Colloidal metal phosphide nanocrystals represent attractive synthetic targets for researchers. They exemplify the diversity of emergent properties presented by nanomaterials, as the class encompasses both semiconductors ... -
Designing the Interface of Transition Metal Phosphides for Electrocatalysis
Colloidally synthesized nanocrystals are a compelling class of materials for catalysis due to their high surface-area-to-volume ratios. The surface chemistry of nanocrystal catalysts is particularly important because of ... -
Investigating Defects and Magnetism in Nanocrystals by Magnetic Spectroscopies
Magnetically-active nanocrystals have long attracted significant attention for their prospective applications in spintronics and other emergent technologies. Additionally, nanocrystals doped with magnetic impurities are ... -
Structural Elucidation of Biomolecular Ions in the Gas Phase Using Novel Mass Spectrometric and Computational Methods
Biological molecules such as protein and DNA play critical roles in various cellular reactions and carry out essential biological functions. But the mechanisms of these reactions, and the essential molecular structures to ... -
Sorting through the JuNK: Using Chemical and Genetic Tools to Probe c-Jun N-Terminal Kinase Allostery and Scaffolding, as well as a General Methodology for Studying Localized Kinase Biology
This dissertation explores the complicated nature of protein kinase allostery and the use of ATP-competitive inhibitors as tools to study kinase function. Much of this work focuses on the c-Jun N-Terminal Kinases (JNKs), ... -
Correlated Electronic and Vibrational Motion: A Direct Perspective Through Multidimensional Electronic-Vibrational Spectroscopy
Developing a thorough mechanistic understanding of photoexcited charge transfer and proton transfer reactions at the molecular-level requires a deep knowledge of coupled electronic and nuclear motion. Two-Dimensional ... -
Insights into Dioxygen Activation by Biomimetic Alkyl Thiolate-Ligated Iron Complexes
Dioxygen activation by non-heme thiolate-ligated Fe-enzymes, such as isopenicillin N synthase (IPNS) and cysteine dioxygenase (CDO) are believed to proceed through several intermediates, including an Fe-superoxo, -hydroperoxo, ... -
Ultrafast Photochemical Reactivity of Heptazine-Based Materials
Solar energy conversion and storage is one key aspect in addressing and mitigating the global energy crisis. Photon conversion efficiencies and production rates of photovoltaics have dramatically increased over the last ... -
A New Approach to 3-Dimensional Super-Resolution Microscopy
Super-Resolution microscopy has transformed our ability to image biological specimens at the nanoscale with high contrast and molecular specificity. However, acquiring 3-dimensional images over large volumes remains a ... -
Chemical Approaches to Investigate the Biochemical Crosstalk Between Histone Sumoylation, Methylation and Acetylation
Histone post-translational modifications (PTM) within chromatin control many DNA-templated cellular processes, from DNA damage repair pathways to gene transcription. In order to understand the influence of PTM on these ... -
Design and Synthesis of Organic Functional Materials for Energy Conversion and Storage Applications
Carbon emission from consumption of fossil fuels has led to global warming accompanying with a large number of environmental issues. In order to lessen the strong dependence on fossil fuels in modern society, it is crucial ... -
Designing nickel- and palladium-based precatalysts to improve catalyst-transfer polymerization towards conjugated polymer synthesis
Catalyst transfer polymerization (CTP) is a versatile synthetic tool to obtain access to sequence specific π-conjugated polymers, which are attractive materials for organic electronics. CTP proceeds through a chain-growth ... -
Targeting RNA Structures that Control Protein Synthesis and RNA Stability
RNA structures play a pivotal role in many biological processes and the progression of human disease, making them an unexploited target for therapeutic development. The first chapter of this thesis reviews features related ... -
Synthesis and Reactivity of PtII Complexes with Secondary Sphere N-H Moieties
Direct transformations of abundant hydrocarbons into higher valued products would circumvent energy intensive processes, reforming the chemical industry. Late transition metals, particularly platinum, are known to selectively ... -
Understanding Ion Injection and Transport in Mixed Ionic/Electronic Conductors
Materials with the ability to conduct both ionic and electronic charge have found a number of new applications recently with real potential to change the world. Each of these applications has its own design requirements, ... -
Development of Organic Photoredox-Mediated Ring-Opening Metathesis Polymerization through Expanded Functionalities of Initiators and Monomers
Ring-opening metathesis polymerization (ROMP), which is derived from transition-metal-based olefin metathesis, has evolved into one of the most prevalent technologies for making functional polymeric materials. Due to the ... -
Understanding lipid membranes' interactions with small molecules and cholesterol using molecular dynamics computer simulations.
Cellular membranes are made up of phospholipids, proteins and cholesterol. The packing of components within the membrane gives rise to important biological phenomena. Understanding these interactions is the most critical ... -
Molecular Dynamics Simulations of DNA Hybridization and Dynamic Force Spectroscopy
A ubiquitous problem in chemistry is determining the energy change of moving from one state to another. Often these states are separated by a large energy barrier which can prevent the observation of the equilibrium ... -
Explorations into the Synthesis and Reactivity of Polynorbornene Frameworks
Polynorbornenes are a highly versatile polymer that allows for much modification of the side chains and multiple methods for polymerization. Chapter 1 introduces our unique photoredox mediated ring-opening metathesis ...
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