Chemistry
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Incorporating Relativistic Effects in the Calculation of Core and Valence Excitations in Metal Complexes and Molecular Clusters
Spectroscopy is one of the most powerful tools humanity has to probe the structure of matter. By seeing how light interacts with the atoms or molecules in a sample, intricate details of the quantum mechanical structure is ... -
New Analytical Tools for Native Mass Spectrometry and Ion Mobility Mass Spectrometry Analysis of Intact Proteins
Native mass spectrometry (MS) is a structural biology tool that probes proteins and protein complexes in the gas phase. In native MS, electrospray ionization (ESI) of protein samples are prepared in nondenaturing conditions ... -
The role of excited-state energy landscapes in directing electron and proton motion for light harvesting applications
To meet the increasing global demand for energy we need to innovate new ways to harness and convert renewable energy sources. Solar energy provides a huge potential to meet these demands, but there is still a plethora of ... -
Advances in Feature Selection in One- and Two-Dimensional Gas Chromatography with Mass Spectrometry
One- and two-dimensional gas chromatography coupled with mass spectrometry provides an enormous amount of quantitative data describing the chemical composition of complex samples. Besides quantification and identification ... -
Cross-linking Methods for 3D Printable Hydrogel Materials
Stimuli-responsive hydrogels have gained increased attention for a broad range of biomedical and biotechnological applications. Synthetic polymeric systems are an attractive platform as they afford tunability through the ... -
The Quantitative Analysis and Modification of Colloidal Nanoparticle Surfaces and Structures
Nanoparticles have consumed the attention of inorganic and materials chemists for decades owing to both their tremendous breadth in composition, size, and shape, as well as the many exceptional physical and chemical ... -
Chemical Tools for Profiling the Allosteric Regulation and Interactomes of Inhibitor-Bound Protein Kinases
This dissertation describes the development of a chemoproteomic method for profiling the interaction network of inhibitor-bound kinase complexes and chemical probes for understanding how ATP-competitive inhibitors can ... -
High-Resolution ENDOR Studies on Vanadyl Porphyrins and Crude-Oil Petroporphyrins
An open area of inquiry in chemistry research is the chemical environment surrounding vanadyl ions and particularly vanadyl porphyrins in crude oil. This is of interest due to the deleterious effect vanadyl has upon the ... -
Studying Intercellular Signaling Underlying Human Diseases Using Open Microfluidic Coculture
This dissertation focuses on the development of innovative open microfluidic cell culture platforms and their application in studying intercellular signaling underlying human diseases in controlled ex vivo microenvironments. ... -
Advanced chemometrics and fundamental considerations for non-targeted analysis with comprehensive multidimensional gas chromatography coupled with time-of-flight mass spectrometry
Comprehensive two-dimensional gas chromatography (GCÃ GC) coupled with time-of-flight mass spectrometry (TOFMS) is a powerful analytical technique capable of separating complex mixtures, providing valuable information about ... -
Fluorescent Labeling Methods for Super-resolution and Optical-sectioning Imaging
Throughout the development of light and fluorescence microscopy, a variety of labeling methods have evolved; from mostly affinity-based labeling used in histological staining to specific labeling using antibodies and ... -
Lipid Membranes: From Organizational Strategies in Cells to the Origins of Life
Lipids, a fundamental building block of cells, can spontaneously self-assemble into vesicles, which are spherical shells consisting of a lipid bilayer. The structure of lipid bilayers determines their biological function: ... -
Spectroscopic Studies on the Impact of Defects in Hybrid Organic-Inorganic Perovskites on Charge Carrier Dynamics and Photovoltaic Device Performance
Photovoltaic devices based on hybrid organic-inorganic perovskites have seen a historic rise in efficiency over the past decade. Relatively low cost of fabrication has allowed a wide range researchers to make meaningful ... -
Nonlinear optical microscopy for tissue imaging and analysis in anatomic pathology
Stimulated Raman Scattering (SRS) microscopy provides chemical information for imaged tissue at submicron resolution. In the experiments described, I combine SRS with other non-linear microscopies, including second harmonic ... -
Organoselenium-Catalyzed Oxidative Transformations of Alkenes
The field of homogeneous catalysis is dominated by transition metals. There exists a vast array of methods available for the conversion of a huge variety of starting materials into an equally diverse collection of useful ... -
Understanding Src Kinase Regulatory Mechanisms and Drug Resistance Using Deep Mutational Scanning and Chemical Biology
Protein phosphorylation controls a wide variety of cellular processes such as growth, differentiation, proliferation, and apoptosis in eukaryotes. Kinases are signaling enzymes that dictate cellular phosphorylation state ... -
Photophysical and Redox Properties of Degenerately Doped Nanocrystals
For the past few decades, semiconductor nanocrystals (NCs) have been the subject of intense interdisciplinary research in both fundamental science and device engineering. Their size-tunable electronic and optical properties, ... -
Developing Catalytically Active Living Materials for Additive Manufacturing
Living materials are created through the embedding of live, whole cells into a matrix that can house and sustain the viability of the encapsulated cells. Through the cell immobilization process, their bioactivity (natural ... -
Development of Biochemical Assays for the Screening, Diagnosis, and Prognosis of Treatable Inborn Errors of Metabolism
Inborn errors of metabolism (IEM) are a phenotypically and genetically heterogenous group of disorders caused by defective enzymes, cofactors or transporters in metabolic pathways, which lead to dysfunctional metabolism ... -
Metal and Gas Adsorption on High-surface-area Catalyst Support Materials: Energetics by Calorimetry and Adsorbate Structure
Along with the increase in the world population and global economy, the world primary energy consumption is also growing year by year, which in turn has brought about energy shortage and global warming. Developing renewable ...
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