Chemistry
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Development of Organic Photoredox-Mediated Ring-Opening Metathesis Polymerization through Expanded Functionalities of Initiators and Monomers
Ring-opening metathesis polymerization (ROMP), which is derived from transition-metal-based olefin metathesis, has evolved into one of the most prevalent technologies for making functional polymeric materials. Due to the ... -
Understanding lipid membranes' interactions with small molecules and cholesterol using molecular dynamics computer simulations.
Cellular membranes are made up of phospholipids, proteins and cholesterol. The packing of components within the membrane gives rise to important biological phenomena. Understanding these interactions is the most critical ... -
Molecular Dynamics Simulations of DNA Hybridization and Dynamic Force Spectroscopy
A ubiquitous problem in chemistry is determining the energy change of moving from one state to another. Often these states are separated by a large energy barrier which can prevent the observation of the equilibrium ... -
Explorations into the Synthesis and Reactivity of Polynorbornene Frameworks
Polynorbornenes are a highly versatile polymer that allows for much modification of the side chains and multiple methods for polymerization. Chapter 1 introduces our unique photoredox mediated ring-opening metathesis ... -
Design and Characterization of Novel Tandem Ion Mobility Mass Spectrometry Instrumentation
Native ion mobility (IM) mass spectrometry (MS) is a gas-phase structural biology technique that couples low-pressure, electrophoretic separation of ions with mass detection to provide low-resolution information on the ... -
Programming Bacterial Gene Expression Using Synthetic CRISPR-Cas Transcriptional Regulators
Bacteria play a central role in biosynthesis to produce value-added organic chemicals due to its diverse carbon and energy source preferences. Implementing synthetic transcriptional regulation devices can advance our ability ... -
Exploring the Photophysics of Engineered and Intrinsic Charge-Carrier Trapping Processes in Semiconductor Nanocrystals
Colloidal semiconductor nanocrystals (NCs) have been a topic of extensive research over the past few decades, as the materials’ photoluminescence (PL) properties are particularly interesting for a variety of applications. ... -
Elucidating Structural Effects of Conjugated Polymers on Charge Transport and Durability for Organic Electronics and Development of Stretchable Semiconducting Materials
Understanding structure-property relationships of π-conjugated polymers is key to the development of functional materials for organic electronics. Molecular structure and polymer chain order strongly influence the electrical ... -
Additive Manufacturing of Mechanoresponsive Polymers
Polymer mechanochemistry has been investigated for the mechanism of mechanical force-induced chemical reactivity within polymers. Many efforts have been made to fine tune the mechanoresponsiveness of the polymeric materials ... -
Bead-based chemistries to quantitate antibody responses to multiple Plasmodium falciparum and Plasmodium vivax antigens
Each year malaria impacts approximately 219 million people and causes over 400,000 deaths. The worldwide parasite burden remains high, even with the availability of efficacious antimalarial drugs and vector control tools ... -
Theoretical and Computational Studies of the Lateral Phases on a Multicomponent Lipid-Bilayer Surface
The lipid-bilayer membrane is the fundamental structure of a cell plasma membrane and has been largely studied by biophysical experiments, theoretical modeling and computer simulations. Two major aspects of lipid bilayer ... -
Mechanisms for Scaffold-Mediated Regulation of Kinase Activity in the Wnt Signaling Pathway
Cellular signaling is a complex process involving numerous pathways. Many of these pathways are connected through shared proteins, creating branch points that may result in crosstalk between pathways. It is not fully ... -
Hydroalkylation of Alkynes via Dual Copper-Nickel Catalysis
Chapter 1 describes the stereospecific synthesis of E-alkenes through a dual copper and nickel catalysis system involving terminal alkynes and primary and secondary alkyl iodides. This reaction proceeds with excellent ... -
Advancements in Single Molecule Localization Microscopy for Improved Multichannel, 3-Dimensional, and Structurally-Dense Imaging
Super-resolution fluorescence microscopy now enables cellular detail to be probed at the nanometer scale using far-field optics with widely available instrumentation. However, single molecule localization microscopy (SMLM) ... -
Dissecting Mechanisms of Antimalarials using CRISPR/Cas9 Editing in Plasmodium falciparum
Malaria, caused by Plasmodium infections, continues to be a global disease of public health importance with 300 million annual cases and about 500,000 deaths. Continual emergence of resistance to commonly used antimalarials ... -
Leveraging Operando Characterization Methods to Reveal Failure and Optimization Mechanisms of Group IV Semiconductor Battery Anodes
Expanding the application space of lithium battery technology will require electrode materials that exhibit performance metrics which outperform their modern counterparts. The availability of prospective next-generation ... -
Cross Coupling of Alkenyl Gold Complexes with Alkyl Electrophiles and Nickel Catalyzed Hydroarylation of Alkenes
Transition metal catalysis is a powerful strategy for the construction of organic molecules. The development of novel methods in this field can help improve the speed and efficiency with which we synthesize complex organic ... -
Modeling Nanomaterials with Efficient and Accurate Electronic Structure Methods
Electronic structure methods are one of the most powerful tools in the computational toolbox to provide an atomistic understanding of molecules and materials. Among all electronic structure methods, Density functional ... -
Novel Mass Spectroscopy Techniques Implementing UV Action Spectroscopy for the Characterization of DNA Cation Radicals and Transition Metal Complexes
Mass spectrometry has become a powerful analytical tool for the detection and characterization of chemical compounds for biological and environmental studies. Advancements in mass spectrometry including new ionization ... -
Partial Modulation Injection for Gas Chromatography
Partial modulation is developed and refined for one-dimensional gas chromatography (1D-GC), comprehensive two-dimensional gas chromatography (GCÃ GC), and comprehensive three-dimensional gas chromatography (GC3). Since ...
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