Chemistry
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Late Transition-Metal Complexes Supported by Pincer Ligands: Applications in Partial Oxidation Catalysis
Late transition-metal pincer complexes of primarily palladium(II) and platinum(II) have been investigated for their application as catalysts in partial oxidation reactions. The epoxidation of higher olefins using molecular ... -
Alkyl-heteroatom Bond Forming Reactions from the Late Transition Metals
C(sp3)-N bond formation is a potential high value reaction in transition metal catalysis, however, only a handful of examples of this fundamental coupling reaction step have been reported. Presented in this thesis are new ... -
Single-Cell Molecular Profiling of Nucleic Acids in the Microfluidic Self-Digitization Chip
In the last four decades, advancements in technologies to copy, measure, and manipulate DNA and RNA in situ have enabled new methods for research and diagnosis of disease. As a subset of these methods, novel microfluidic ... -
Helping Observe and Tune Diffusion Using Mn2+ Photophysics in Inorganic Nanocrystals after Growth
Doped inorganic crystals exhibit attractive optical, electrical, and magnetic properties that enabled the development of important modern technologies including ruby lasers and silicon microelectronics. The next frontier ... -
Development of a Small Molecule Regulated Cre Recombinase and A Chemical-Genetic Strategy for the Investigation of Kinase Non-Catalytic Function using Covalent Conformation-Selective Inhibitors
Chapter 1: Development of a Small Molecule Regulated Cre Recombinase Our lab has previously developed a chemical genetic method for controlling signaling enzymes with a small molecule. In this method, the endogenous ... -
Exploring the Thermal and Mechanochemical Reactivity of 1,2-Oxazine Hetero Diels-Alder Adducts for Stimuli-Responsive Polymers
Stimuli-responsive materials is an area of significant research with a broad scope of applications in fields such as drug delivery, self-healing materials, and lithography. The ideal stimuli-responsive polymer construct ... -
Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-Phase Structures of Protein and Protein Complex Ions
This dissertation reports the development of new ion mobility mass spectrometry (IM-MS) instrumentation to analyze protein and protein complex ions. IM-MS is a gas-phase analytical technique that separate ions based on ... -
Preparation and Characterization of Iridium Hydride and Dihydrogen Complexes Relevant to Biomass Deoxygenation
This thesis describes the fundamental organometallic reactivity of iridium pincer complexes and their applications to glycerol deoxygenation catalysis. These investigations provide support for each step of a previously ... -
New Tandem Mass Spectrometric Methods of Structure and Sequence Elucidation of Synthetic and Tryptic Peptides
Over the last few decades, technological advances in the physical and life sciences have enabled scientists to look at various systems ever so intricately and to gather evidence for the mechanisms behind these systems, be ... -
Development of Instrumental and Computational Methods for Accessing Information in Multi-Dimensional Gas Chromatography with Mass Spectrometry
Three instrumental and computational methods are demonstrated in an endeavor to create novel techniques to extract information from the troves of data generated by multi-dimensional gas chromatography with mass spectrometry. ... -
Spectroscopic Characterization of Interfacial Charge Transfer and Recombination in Polymer/Quantum Dot Blends
Considerable research interest in solution-processed semiconductors, including conjugated polymers and colloidal quantum dots, has been primarily motivated by the desire to produce optoelectronic devices using low-cost ... -
Development of Fluorescence-Enabled Electrochemical Microscopy for Electrochemical Imaging and Detection
This dissertation discusses various aspects of the fundamental development of fluorescence-enabled electrochemical microscopy (FEEM) into a useful analytical tool for electrochemical imaging and detection. Chapter 1 briefly ... -
Characterization and Exploitation of Bidirectional Allosteric Coupling in Multi-Domain Tyrosine Kinases using Conformation-Selective ATP-Competitive Inhibitors
Protein kinases are a large family of enzymes that play integral roles in cell signaling networks and are thus critical for effecting appropriate cellular responses to environmental stimuli. Much of kinase biological ... -
Pin the Protein on the Membrane: Using Numerical Simulations to Explore Membrane-Protein Systems
The structure of the membrane gives rise to important biological phenomena. In this dissertation we focus on the shape of the membrane and its interactions through two different coupling schemes to membrane bound proteins. ... -
Fundamental Insights into Catalyst Design: Energetics of Metal Atom Adsorption and Nanoparticle Adhesion on Oxide Surfaces
Heterogeneous catalysts consisting of transition metal nanoparticles dispersed on high surface area oxide supports are ubiquitous in industrial-scale chemistry and alternative energy technology. Despite their importance, ... -
A Theoretical and Synthetic Investigation of New Donors for Organic Electro-Optic Chromophores: Understanding the Effects of Structure and Substituents on Donor Strength
Understanding of the intricate connection between shape, structure and property has al- lowed many challenges facing the adoption of organic chromophores for electro-optic (EO) applications to be overcome. Still, there is ... -
It’s a Trap! Unravelling Reversible Charge Trapping in Nanocrystals Through Single Particle and Ensemble Studies
Copper containing semiconductors such as copper-doped ZnS and CuInS2 are classic phosphors materials that have had wide general use for decades. The photophysical processes of these bulk materials have been well studied. ... -
Palladium-Catalyzed Cross-Couplings of 2-Alkylaziridines and Alkenylboronic Acids
A new method to synthesize substituted homoallylic amines is reported. Homoallylic amines are important structural moieties in natural products and pharmaceutical agents. The reaction couples N-nosyl-2-alkylaziridines with ... -
Positive Encounters: An Investigative Study on the Effects of Interactions between Cations and Quantum Dots
Semiconductor nanocrystals, also known as quantum dots (QDs), have gained much popularity in recent years not only in the researching community but also in general public. Within researching circles, there are many areas ... -
Insight into Biological Small-Molecule Activation from Enzymes, Model Complexes, and X-ray Spectroscopy
This dissertation covers the investigation of biological strategies for activating inert small molecules. Chapters 1 and 2 respectively present an introduction to some notable biological systems of interest and the X-ray ...
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