Chemistry
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Electron Energy-Loss Spectroscopy: Analytical Theory and Numerical Simulations of Individual Nanoparticles and Nanostructures
The field of nanotechnology has experienced rapid growth over the past three decades which can largely be attributed to advances in technologies and experimental techniques. One technology in particular, the electron ... -
Photo and Electrochemical Investigations of Solution Processable Molecules and Materials for the Hydrogen Evolution Reaction
Sustainable hydrogen production photoelectrochemically or photocatalytically is a desirable process that has the potential to allow hydrogen to be utilized as a carbon free fuel. In order for this method to become commercially ... -
Characterization of the Structures of Small Peptides and their Interactions with Inorganic Minerals
Proteins mediate the nucleation and growth of many biominerals, yet the specifics of these protein-mineral interactions are often poorly understood. The focus of this dissertation is to better understand these interactions ... -
On the Excited States Formed During Interfacial Charge Transfer and Recombination in Organic Bulk Heterojunction Photovoltaic Devices
The optimization and implementation of organic photovoltaic (OPV) devices as low-cost and highly modular power sources are complicated by the intricacies of materials design and processing. Small variations in molecular ... -
Utilizing Molecular Dynamics' Multipotent Methodologies to Measure Microscopic Motions of DNA Molecules: A Magniloquent Manuscript on DNA’s Means and Mannerisms
DNA is an amazing molecule which is the basic template for all genetics. It is the primary molecule for storing biological information, and has many applications in nanotechnology. Double-stranded DNA may contain mismatched ... -
Preparation, Characterization, and Reactivity of Ruthenium Protic N-Heterocyclic Carbene Complexes
As carbon dioxide levels continue to rise in our atmosphere, scientific interest has peaked around the capture and utilization of CO2. Not only does CO2¬¬ have the potential to be used as a C1 building block for the ... -
Probing Local Heterogeneity in the Optoelectronic Properties of Organic-Inorganic Perovskites Using Fluorescence Microscopy
Unregulated emission of carbon dioxide and greenhouse gases into our atmosphere has led to an increase in the average global surface air temperature, to a disruption of weather patterns, and to the acidification of oceans ... -
Correlating nanoscale optoelectronic and mechanical properties of solution processable thin film photovoltaic materials using scanning probe microscopy
Solution processable materials present a competitive alternative to traditional silicon solar cells based on inexpensive processing and flexible form factors. Several competing technologies have entered the market in the ... -
New Tools for Studying Nanoscale Electrochemical Phenomena
This dissertation focuses primarily on the fabrication of micro and nanoscale electrochemical structures such as electrodes, electrode arrays, and nanopores. It also discusses the use of these tools in studying nanoscale ... -
Reversibly Reconfigurable Plasmonic Nanomaterials
University of Washington Abstract Reversibly Reconfigurable Plasmonic Nanomaterials Soumyadyuti Samai Chair of the Supervisory Committee: Professor David S. Ginger Department of Chemistry Plasmonic nanoparticles have been ... -
The Role of Precursor Conversion in the Nucleation and Growth of Zinc Pnictide Based Semiconductor Quantum Dots
Interest in the synthesis of colloidal semiconductor nanocrystals has boomed over the last thirty years. This is, in part, due to the tunable optoelectronic properties of these colloids, which stems from the quantum ... -
Investigation of the Fundamentals of Electrospray Ionization and the Separation of Small Molecules using Ion Mobility Mass Spectrometry
Ion mobility mass spectrometry (IM-MS) is a gas-phase technique used to separate ions based on their mass-to-charge ratio and collision cross section (i.e. shape). Accurate MS analysis of analytes, such as proteins and ... -
Hallmarks of Reversible Phase Separation in Living, Unperturbed Cell Membranes
Controversy has long surrounded the question of whether spontaneous lateral demixing of membranes into coexisting liquid phases can organize proteins and lipids on micron scales within unperturbed, living cells. A clear ... -
Development of auxiliary-mediated protein semisynthesis methods toward the study of histone SUMOylation
Eukaryotic DNA is packaged into chromatin, which consists of a fundamental repeating unit, the nucleosome, and its associated proteins. Nucleosomes are made up of histone protein octamers, containing two each of histones ... -
Electronic and Geometric Structure of Biological Spin Centers Investigated with EPR Spectroscopy
In this dissertation, the fundamental concepts and techniques of electron paramagnetic resonance (EPR) spectroscopy, which are important for understanding electronic structure and relating it to geometric structure, are ... -
Caps - Turns - Loops: Designing Better β-Hairpins
As protein engineering promises advances in almost every field of science and medicine, a greater understanding of the protein folding problem is necessary to make these innovations a reality. This thesis examines one ... -
Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway and Toward Discovery of Inhibitors of Human Group III Secreted Phospholipase A2 and Lessons Learned from In Vivo Mouse Studies of Secreted Phospholipase A2 Clearance from Extra-Cellular Medium by the M-type Receptor
Chapter I. Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway The serine hydrolase inhibitors Pyrrophenone and KT195 were found to inhibit cell death induced by A23187 and H2O2 in mouse lung ... -
Small-Molecule Gated Artificial Regulatory Domains: A Novel Tool For Dissecting Signaling Pathways
The activities of the proteins involved in eukaryotic signaling networks are controlled by a complex system of allosteric regulatory domains, in which auto-inhibitory interacting domains repress protein activity. The field ... -
Copper-Catalyzed Synthesis of Alkyl Fluorides, Sterically Hindered Anilines, and 1,4-Dienes
Copper is a versatile transition metal and has been used as a catalyst for constructing a variety of bonds in organic synthesis. It is relatively abundant, cheap, and less toxic than other transition metals, making it an ... -
Cells Incognito: Microfluidic Tools for Detecting and Isolating Cancer Cells
Cancer continues to be one of the leading causes of death around the world. The disease is characterized by uncontrolled cell growth and is spread throughout the body by the dissemination of cancer cells into circulation. ...
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