Chemistry
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Development of chemometric methodologies for supervised class-based discovery experiments using GCÃ GC-TOFMS: application to aerospace fuel analysis
Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection (GCÃ GC-TOFMS) is a prominent instrumental technique which produces information rich datasets for the analysis of complex ... -
Working Toward a Long-Term, Real-Time Measurement Network for Atmospheric Aerosol Sources
Aerosols have a significant impact on both human health and the Earth’s climate. Due to their complexity and variety, however, relatively little is known about them. ASCENT is a new aerosol measuring network that aims to ... -
Protocell development within evaporating lakes on the early Earth
My research addresses the problem of how the first cells assembled from non-living material in the early Earth environment by testing whether putative components of the first cells could have assembled within evaporating ... -
Photophysical Properties of Quantum-Cutting Ytterbium(III)-Doped Perovskite Nanocrystals
Ytterbium(III)-doped all-inorganic lead-halide perovskites (Yb3+:CsPb(Cl1-xBrx)3) have recently been discovered to display highly efficient quantum cutting, in which the energy from each ultraviolet photon absorbed by the ... -
Leveraging Molecular Nanoclusters for Atomistic Insights into Reactive Interfaces
Tuning metal/support interactions represents a powerful strategy to modulate catalytic activity, making supported single-site catalysts that harness these effects an active frontier of research. However, probing the complex ... -
Application of HS-SPME-GC for Sample Classification
The thesis presents two studies related to the analysis of volatile organic compounds(VOCs) in various samples using solid-phase microextraction gas chromatography (SPME-GC). The first study focuses on improving the ... -
Dancing at the Interface: Surface-Mediated Active Site Dynamics within Molecular Nanoclusters
The key to accessing next-generation heterogeneous catalysts, which lie at the heart of many industrial manufacturing and energy conversion processes, is the identification and detailed surveillance of the catalytic active ... -
Cross-Nucleophile coupling: synthesis of a new C-C bond between alkylboranes and boronates
Many general methods are now available for the cross-coupling of carbon nucleophiles with carbon electrophiles, and even the couplings between two electrophiles have been gradually developed in the last decade. There remain ... -
Using Reduced Dimensional Models to Interpret Spectral Signatures of Large Amplitude Motions of OH Bonds
Understanding the spectral signatures of hydrogen bonding is an ongoing topic of study inphysical chemistry. Determining the origins of these spectral signatures will lead to increased understanding of the underlying physics ... -
Structural Effects on the Kinetics and Thermodynamics of Making and Breaking O-O Bonds
Nature has developed enzymes over millennia that perform difficult chemical transformations in mild conditions, using structural controls to aid in the generation of powerful reactive intermediates. Metalloenzymes such as ... -
Experimental implementation of third-order nonlinear infrared spectroelectrochemistry
Infrared (IR) spectroelectrochemistry (SEC) is a field with both established and emerging techniques. This work presents a broadly applicable and extensively modular IR-SEC design that’s specialized for laser table ... -
Approaching Accurate Description of Molecular Spectroscopies with Multi-reference Electronic Structure Methods
In this dissertation we aim to approach an accurate description of molecular spectroscopy with multi-reference electronic structure methods, for the investigation of real-world problems. Among the challenges that our society ... -
CRISPR-Cas Tools for Engineering Genome Structure and Gene Expression
This thesis focuses on the development of two distinct sets of CRISPR-Cas tools: one for gene tethering and the other for logic-based transcriptional regulation. The first tool is a CRISPR-based gene tethering tool. The ... -
Into the unknown: Exploring the surface chemistry of black phosphorus
Black phosphorus (bP), a layered 2D allotrope of elemental phosphorus, is a promising material for electronic and catalytic applications, among others, due to its direct, tunable bandgap, high carrier mobility, and relatively ... -
Enabling Multidimensional Ion Mobility Separations Using Structures for Lossless Ion Manipulations
This dissertation describes the development and application of multidimensional ion mobility (IM) techniques using the modular Structures for Lossless Ion Manipulations (SLIM) architecture. IM is an analytical technique ... -
Multiplexed, Single-Cell Profiling of Chromatin States with Expansion Microscopy
Proper regulation of genome architecture and activity is essential for the development and function of multicellular organisms. Histone modifications can act in combination to specify these activity states at individual ... -
Global Methods for Discovering and Characterizing Regulatory Mechanisms of Multi-Domain Protein Kinase
Perturbations to cellular phosphorylation levels are highly correlated with a variety of disease states. Because protein kinases are the enzymes responsible for protein phosphorylation, they play a central role in maintaining ... -
Theoretical advances in signal analysis of DEER spectroscopy
Electron paramagnetic resonance (EPR) spectroscopy has been established as an indispensable tool for a wide range of scientific fields. Within the field of EPR, pulse methods, particularly those that measure dipolar ... -
Structural investigations of ytterbium dopant sites and elpasolite nanocrystal structure
The relationship between molecular and materials structure and observed properties is a pillar of chemistry and materials science. Understanding the structural character of materials at both the bulk and nanoscale is ... -
Leveraging Open Microfluidic Patterning and Home Blood Sampling and Stabilization to Advance Tissue Engineering and Translational Research
Engineered systems and microfluidic devices have long been used to gain insight into a range of disciplines in the medical sciences, from three-dimensional (3D) bioprinting to home biofluid sampling devices. This dissertation ...
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