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Browsing Chemistry by Title
Now showing items 111-130 of 463
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Development and Expansion of Tools for Data-Driven Materials Development
Machine learning and natural language processing techniques are being integrated into chemistry and materials science, finding utility at field and domain levels of research. While these tools have existed, the relative ... -
Development and Mechanistic Study of Copper-Based Water Oxidation Catalysts
(2013-11-14)Water oxidation is a challenging reaction that has great importance for alternative energy and fuel generation. Although several water oxidation catalysts have been discovered, much improvement is needed for the technology ... -
Development of a machine learning pipeline to analyze biological multiple particle tracking datasets
Multiple Particle Tracking (MPT) has been demonstrated as an important tool for understanding changes to biological environments. MPT studies are capable of generating gigabytes of data across hundreds to thousands of ... -
Development of a Small Molecule Regulated Cre Recombinase and A Chemical-Genetic Strategy for the Investigation of Kinase Non-Catalytic Function using Covalent Conformation-Selective Inhibitors
Chapter 1: Development of a Small Molecule Regulated Cre Recombinase Our lab has previously developed a chemical genetic method for controlling signaling enzymes with a small molecule. In this method, the endogenous ... -
Development of auxiliary-mediated protein semisynthesis methods toward the study of histone SUMOylation
Eukaryotic DNA is packaged into chromatin, which consists of a fundamental repeating unit, the nucleosome, and its associated proteins. Nucleosomes are made up of histone protein octamers, containing two each of histones ... -
Development of bead injection methodology for immunoassays
(2003)The research presented in this thesis develops Bead Injection techniques for application in immunological research and with the aim of developing rapid screening methods for use in clinical settings.A method is introduced, ... -
Development of Biochemical Assays for the Screening, Diagnosis, and Prognosis of Treatable Inborn Errors of Metabolism
Inborn errors of metabolism (IEM) are a phenotypically and genetically heterogenous group of disorders caused by defective enzymes, cofactors or transporters in metabolic pathways, which lead to dysfunctional metabolism ... -
Development of Catalytic Processes for the Transformation of Low Value Chemical Feedstocks to Value Added Chemicals
(2013-11-14)Dwindling oil reserves have necessitated the shift to alternative sources for fuels and commodity chemicals. This thesis describes fundamental studies and development of catalytic processes for the transformation of abundant, ... -
Development of chemometric methodologies for supervised class-based discovery experiments using GCÃ GC-TOFMS: application to aerospace fuel analysis
Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection (GCÃ GC-TOFMS) is a prominent instrumental technique which produces information rich datasets for the analysis of complex ... -
Development of CRISPR-Cas tools towards rewiring 3D genome structure
New genomic methods have revealed a high level of spatial organization in the nucleus, and the subnuclear positioning of genes correlates with transcriptional activity. It is thought that 3D genome organization and positioning ... -
Development of Fluorescence-Enabled Electrochemical Microscopy for Electrochemical Imaging and Detection
This dissertation discusses various aspects of the fundamental development of fluorescence-enabled electrochemical microscopy (FEEM) into a useful analytical tool for electrochemical imaging and detection. Chapter 1 briefly ... -
Development of grating light reflection spectroscopy for chemical sensing applications
(2000)Grating Light Reflection Spectroscopy (GLRS) exploits the interaction of light with a transmission diffraction grating in contact with a sample. With this technique, light reflected from the grating exhibits a redistribution ... -
Development of Instrumental and Chemometric Techniques for the Analysis of Complex Samples via Multi-Dimensional Gas Chromatography
A combination of four instrumental systems and five chemometric methods are shown to improve the efficiency and resolving power (i.e. peak capacity/ peak capacity production) of multi-dimensional gas chromatography (MDGC) ... -
Development of Instrumental and Computational Methods for Accessing Information in Multi-Dimensional Gas Chromatography with Mass Spectrometry
Three instrumental and computational methods are demonstrated in an endeavor to create novel techniques to extract information from the troves of data generated by multi-dimensional gas chromatography with mass spectrometry. ... -
Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-Phase Structures of Protein and Protein Complex Ions
This dissertation reports the development of new ion mobility mass spectrometry (IM-MS) instrumentation to analyze protein and protein complex ions. IM-MS is a gas-phase analytical technique that separate ions based on ... -
Development of Lysine-Targeted Probes for Protein Kinases
Lysine is one of the most common amino acids in the proteome, but relatively few probes have been designed to label specific lysine. Properties of lysine such as its low intrinsic nucleophilicity and its ubiquity has made ... -
Development of Mass Spectrometry-Based Assays for Newborn Screening: Novel Approaches to Lysosomal Acid Lipase and the Mucopolysaccharidoses
Newborn screening has been an important public health tool for over fifty years. As technology improves, new testing has developed for rare diseases including lysosomal storage disorders (LSDs) in parallel with novel ... -
Development of New Modulation Methods Using the Pulse Valve Modulator for Multidimensional Gas Chromatography
The potential efficiency and applicability of gas chromatography is advanced through the continued development and use of the pulse valve modulator. New advancements in modulation techniques are reported with the pulse ... -
Development of Newborn Screening Methods for Mucopolysaccharidosis III type A and type B in Dried Blood Spot using Tandem Mass Spectrometry
Chapter I. Development of Newborn Screening Method for Mucopolysaccharidosis III Type A in Dried Blood Spot using Tandem Mass Spectrometry Mucopolysaccharidosis III type A (MPS III A) is an autosomal recessive inherited ... -
Development of Novel Direct Arylation Methodology for the Synthesis of Conjugated Polymers
Conjugated polymers (CP) represent an important class of materials in the field of organic electronics. From the seminal Nobel prize-winning studies on the semiconducting properties of polyacetylene in the 1970s, the ...