Browsing Chemistry by Subject "Analytical chemistry"
Now showing items 21-40 of 53
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Fluorescence-Enabled Electrochemical Microscopy and Nanoscale Electrochemical Analysis
(2013-07-25)This dissertation discusses the fundamental study of several electroanalytical chemistry tools and methods. Unifying factors between the various chapters include the use of nano and microscale materials for electrode ... -
Fundamental Considerations in One and Two-Dimensional Chromatography for Improved Chemometric Analysis
One and two-dimensional chromatography offer well-established instrumental platforms that produce separations of chemical compounds in complex samples in a variety of fields and applications and when coupled with spectral ... -
Fundamental studies of Rocket propellant fuel using GC × GC - TOFMS instrumentation with chemometric data analysis
University of Washington Abstract Fundamental studies of Rocket propellant fuel using GC × GC &mdash TOFMS instrumentation with chemometric data analysis. Benjamin Kehimkar Chair of the Supervisory Committee: Professor ... -
Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States
This dissertation explores the utility of cation-to-anion proton transfer reactions (CAPTR) in native mass spectrometry, and investigates the relationship between the charge state (z) and collision cross section (Ω) of ... -
Investigation of supervised and unsupervised discovery–based chemometric tools to expand the scope of multidimensional gas chromatography
Comprehensive two-dimensional gas chromatography (GCÃ GC) has emerged as a powerful multidisciplinary tool for the separation of complex mixtures since its inception in 1991. When coupled to a time-of-flight mass spectrometer ... -
Investigation of the Fundamentals of Electrospray Ionization and the Separation of Small Molecules using Ion Mobility Mass Spectrometry
Ion mobility mass spectrometry (IM-MS) is a gas-phase technique used to separate ions based on their mass-to-charge ratio and collision cross section (i.e. shape). Accurate MS analysis of analytes, such as proteins and ... -
Ion Spectroscopy Studies of DNA Cation Radicals Generated from Electron Transfer and Collision-Induced Dissociations
This dissertation reports the UV/Vis spectroscopic investigations of transient DNA cation radical intermediates generated from collision-induced dissociation and electron transfer dissociation. To generate cation radicals ... -
Leveraging Open Microfluidic Patterning and Home Blood Sampling and Stabilization to Advance Tissue Engineering and Translational Research
Engineered systems and microfluidic devices have long been used to gain insight into a range of disciplines in the medical sciences, from three-dimensional (3D) bioprinting to home biofluid sampling devices. This dissertation ... -
Leveraging Open Microfluidics for Platform Development and Cell-Signaling Studies In Vitro
This dissertation discusses the fundamentals, development, validation, and application of open microfluidic technologies as a research tool in biological studies. Open microfluidics is a rapidly evolving and expanding ... -
Measurement of Dissolved Oxygen in Highly Restricted (PIcoliter) Volumes Utilizing Thin Film Luminescent Sensors
(2013-07-25)Researchers at the Microscale Life Sciences Center undertook an ambitious project to examine the metabolic and genomic processes in single mammalian cells related to esophageal adenocarcinomas in Barrett's Esophagus patients. ... -
Molecular Composition, Volatility, and Formation Mechanisms of Biogenic Secondary Organic Aerosol
The research herein seeks to answer the following question: what are the main processes governing the formation and properties of secondary organic aerosol (SOA) from oxidation of biogenic volatile organic compounds (BVOC) ... -
Native Ion Mobility Mass Spectrometry: Characterizing Biological Assemblies and Modeling their Structures
Native mass spectrometry (MS) is an increasingly important structural biology technique for characterizing protein complexes. Conventional structural techniques such as X-ray crystallography and nuclear magnetic resonance ... -
New Analytical Tools for Native Mass Spectrometry and Ion Mobility Mass Spectrometry Analysis of Intact Proteins
Native mass spectrometry (MS) is a structural biology tool that probes proteins and protein complexes in the gas phase. In native MS, electrospray ionization (ESI) of protein samples are prepared in nondenaturing conditions ... -
New Electroanalytical Tools for Exocytosis: From Single Cells Toward Single Vesicles
This dissertation focuses on the development and application of new electroanalytical tools for the measurement of neurotransmitter release (e.g. dopamine, norepinephrine, epinephrine) from vesicles. Advancements in biosensor ... -
New Electrochemical Methods for Studying Nanoparticle Electrocatalysis and Neuronal Excocytosis
(2013-04-17)This dissertation presents the construction and application of micro and nanoscale electrodes for electroanalytical analysis. The studies presented herein encompass two main areas: electrochemical catalysis, and studies ... -
New Ion Mobility-Mass Spectrometry Tools to Characterize and Differentiate Similar Proteins
This dissertation describes new ion mobility-mass spectrometry (IM-MS) approaches for the characterization and differentiation of similar proteins, namely antibodies. Antibodies form the basis of a growing class of ... -
New Mass Spectrometry Approaches to Investigate Proteins and Protein Interactions
Mass spectrometry (MS) is essential for understanding the composition, structures, and interactions of proteins. There are various forms of MS that can be used to obtain valuable information about proteins and protein ... -
New Microfabricated Tools for Electrochemical Imaging and Sensing
This dissertation covers the development of microfabricated bipolar ultramicroelectrode arrays consisting of many thousands of individually addressable electrodes to enable high resolution electrochemical imaging. Two ... -
New Tools for Studying Nanoscale Electrochemical Phenomena
This dissertation focuses primarily on the fabrication of micro and nanoscale electrochemical structures such as electrodes, electrode arrays, and nanopores. It also discusses the use of these tools in studying nanoscale ... -
Novel Electroanalytical Tools for Probing Electrochemically Generated Surface Nanobubble Characteristics
Gaseous surface nanobubbles are produced in numerous electrochemical reactions of utmost economic and industrial importance. Despite the need to understand surface nanobubble characteristics and dynamics for continued ...