Browsing Chemistry by Title
Now showing items 234-253 of 453
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Kinetic Insights into Dioxygen Activation by Biomimetic Thiolate-Ligated Iron Complexes
Non-heme thiolate-ligated metalloenzymes such as isopenicillin N synthase (IPNS) and cysteine dioxygenase (CDO) active dioxygen to produce catalytic oxidative intermediates including metal -superoxos, -hydroperoxos, and ... -
Label Transfer Reagents for the Investigation of Protein Kinase Complexes
(2013-02-25)Protein kinases are essential enzymes for cellular signaling, and are often regulated by participation in protein complexes. The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation ... -
Late Transition Metal Pre-Catalysts for the Hydrogenation of Carbonyl-Containing Substrates
This thesis describes efforts to develop new pre-catalysts for the hydrogenation of challenging carbonyl substrates, including esters and amides. We seek to understand the mechanisms by which these catalysts operate, and ... -
Late Transition-Metal Complexes Supported by Pincer Ligands: Applications in Partial Oxidation Catalysis
Late transition-metal pincer complexes of primarily palladium(II) and platinum(II) have been investigated for their application as catalysts in partial oxidation reactions. The epoxidation of higher olefins using molecular ... -
Leveraging Molecular Nanoclusters for Atomistic Insights into Reactive Interfaces
Tuning metal/support interactions represents a powerful strategy to modulate catalytic activity, making supported single-site catalysts that harness these effects an active frontier of research. However, probing the complex ... -
Leveraging Open Microfluidic Patterning and Home Blood Sampling and Stabilization to Advance Tissue Engineering and Translational Research
Engineered systems and microfluidic devices have long been used to gain insight into a range of disciplines in the medical sciences, from three-dimensional (3D) bioprinting to home biofluid sampling devices. This dissertation ... -
Leveraging Open Microfluidics for Platform Development and Cell-Signaling Studies In Vitro
This dissertation discusses the fundamentals, development, validation, and application of open microfluidic technologies as a research tool in biological studies. Open microfluidics is a rapidly evolving and expanding ... -
Leveraging Operando Characterization Methods to Reveal Failure and Optimization Mechanisms of Group IV Semiconductor Battery Anodes
Expanding the application space of lithium battery technology will require electrode materials that exhibit performance metrics which outperform their modern counterparts. The availability of prospective next-generation ... -
Lewis Acid Passivation of Mechanically Exfoliated Black Phosphorus
Exfoliated black phosphorus (exf-BP) is a 2D material with a tunable bandgap and favorable electron transport properties for optoelectronic applications. However, its instability under ambient conditions presents challenges ... -
Lipid Membranes: From Organizational Strategies in Cells to the Origins of Life
Lipids, a fundamental building block of cells, can spontaneously self-assemble into vesicles, which are spherical shells consisting of a lipid bilayer. The structure of lipid bilayers determines their biological function: ... -
Liquid chromatographic separation and sensing principles with a water only mobile phase
(1996)Two separate subjects will be developed in this work. The first subject is a novel chemical analyzer based on a polymer clad optical fiber inserted into a transparent capillary tube. This configuration is referred to as ... -
Local Imaging of Optoelectronic Properties and Film Degradation in Polymer/Fullerene Solar Cells with Electrostatic Force Microscopy
With power conversion efficiencies on the rise, organic photovoltaics (OPVs) hold promise as a next-generation thin-film solar technology. However, both device performance and stability are inextricably linked to local ... -
Localization of the Human Malaria Parasite's Dihydrofolate Reductase-Thymidylate Synthase and Examining Its Role in Proguanil and Atovaquone Drug Synergy
Malaria is the common name for a disease caused by <italic>Plasmodium</italic> parasites. Malaria kills an estimated 1 million people out of approximately 200 to 500 million cases annually. The incredible number of cases ... -
Long-lived charge carrier dynamics in polymer/quantum dot blends and organometal halide perovskites
Solution-processable semiconductors offer a potential route to deploy solar panels on a wide scale, based on the possibility of reduced manufacturing costs by using earth-abundant materials and inexpensive production ... -
Long-lived charge carrier dynamics in polymer/quantum dot blends and organometal halide perovskites
Solution-processable semiconductors offer a potential route to deploy solar panels on a wide scale, based on the possibility of reduced manufacturing costs by using earth-abundant materials and inexpensive production ... -
Luminescent Manganese in Nanocrystals
Manganese doped semiconductors such as ZnSe are classic phosphor materials that have been in wide use for many decades, and a great deal of research has been done on their optical, physical and magnetic properties. Recent ... -
Manganese(II) in Semiconductor Nanocrystals
(2014-04-30)The following chapters describe the state of II-VI semiconductor nanocrystal preparation. Introduction of transition metal dopants gave rise to new materials and provided an insight into both physical and chemical properties ... -
Measurement of Dissolved Oxygen in Highly Restricted (PIcoliter) Volumes Utilizing Thin Film Luminescent Sensors
(2013-07-25)Researchers at the Microscale Life Sciences Center undertook an ambitious project to examine the metabolic and genomic processes in single mammalian cells related to esophageal adenocarcinomas in Barrett's Esophagus patients. ... -
Mechanisms for Scaffold-Mediated Regulation of Kinase Activity in the Wnt Signaling Pathway
Cellular signaling is a complex process involving numerous pathways. Many of these pathways are connected through shared proteins, creating branch points that may result in crosstalk between pathways. It is not fully ... -
Mechanistic analysis of scaffold contributions to specificity and insulation in Wnt signaling
Glycogen Synthase Kinase 3β (GSK3β) plays a pivotal role in a large number of signaling pathways. To avoid cross-pathway interference, signaling pathways that rely on GSK3β must have regulatory features that allow signals ...