Browsing Chemistry by Title
Now showing items 279-298 of 453
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Native Ion Mobility Mass Spectrometry: Characterizing Biological Assemblies and Modeling their Structures
Native mass spectrometry (MS) is an increasingly important structural biology technique for characterizing protein complexes. Conventional structural techniques such as X-ray crystallography and nuclear magnetic resonance ... -
A neutralization-reionization mass spectrometry and computational analysis of 3-hydroxypyridine, 2-hydroxypyridine/2-(1H)pyridone, and uracil
(2000)Free radical damage to DNA has been studied since the early years of radiobiology, when it became well established that DNA, and specifically the purine and pyrimidine bases are critical cellular target for radiation-induced ... -
New Analytical Tools for Native Mass Spectrometry and Ion Mobility Mass Spectrometry Analysis of Intact Proteins
Native mass spectrometry (MS) is a structural biology tool that probes proteins and protein complexes in the gas phase. In native MS, electrospray ionization (ESI) of protein samples are prepared in nondenaturing conditions ... -
New Approaches for the Synthesis of Alkenes
Alkenes are an important class of compounds common among biologically active molecules and often used as intermediates in organic synthesis. Many alkenes can exist in two stereoisomeric forms (E and Z), which have different ... -
New Copper-Catalyzed Reactions of Organoboron and Organosilicon Compounds
(2013-11-14)Copper-catalyzed transformations such as allylic substitution, conjugate addition, and electrophilic amination have proven to be indispensable tools for the formation of carbon-carbon and carbon-heteroatom bonds. ... -
New Electroanalytical Tools for Exocytosis: From Single Cells Toward Single Vesicles
This dissertation focuses on the development and application of new electroanalytical tools for the measurement of neurotransmitter release (e.g. dopamine, norepinephrine, epinephrine) from vesicles. Advancements in biosensor ... -
New Electrochemical Methods for Studying Nanoparticle Electrocatalysis and Neuronal Excocytosis
(2013-04-17)This dissertation presents the construction and application of micro and nanoscale electrodes for electroanalytical analysis. The studies presented herein encompass two main areas: electrochemical catalysis, and studies ... -
New Electrochemical Strategies for Studying Single Nanoparticles
This dissertation describes new advances and applications of single nanoparticle collision electrochemistry and is divided into two broad sections. First, new methods are described to overcome longstanding limitations of ... -
New Mass Spectrometry Approaches to Investigate Proteins and Protein Interactions
Mass spectrometry (MS) is essential for understanding the composition, structures, and interactions of proteins. There are various forms of MS that can be used to obtain valuable information about proteins and protein ... -
New Methods for Investigating the Interplay of Photoluminescence Intermittency and Local Dielectric Constant
New experimental and data analysis methods for investigating the influence of local environment on the photoluminescence intermittency (PI) or "blinking" exhibited by single luminophores are presented. Specifically, the ... -
New Microfabricated Tools for Electrochemical Imaging and Sensing
This dissertation covers the development of microfabricated bipolar ultramicroelectrode arrays consisting of many thousands of individually addressable electrodes to enable high resolution electrochemical imaging. Two ... -
New Selenium Catalyzed Reactions and Computational Chemistry to Understand Regio- and Diastereoselectivities: Directed C-H Allylic Amination
Allylic amines are an important class of nitrogen-containing compounds for use in synthesis or medicinal properties. Direct strategies to make allylic amines involve activation of an allylic C-H bond (allylic C-H amination), ... -
New Statistical Inference Methods for DEER Spectroscopy on Proteins
Double Electron-Electron Resonance (DEER) spectroscopy is a pulse-EPR experiment that can provide sub-ångström resolution distance measurements of proteins and other biomacro- molecules in the distance range of about 2-16 ... -
New Tandem Mass Spectrometric Methods of Structure and Sequence Elucidation of Synthetic and Tryptic Peptides
Over the last few decades, technological advances in the physical and life sciences have enabled scientists to look at various systems ever so intricately and to gather evidence for the mechanisms behind these systems, be ... -
New Tools for Studying Nanoscale Electrochemical Phenomena
This dissertation focuses primarily on the fabrication of micro and nanoscale electrochemical structures such as electrodes, electrode arrays, and nanopores. It also discusses the use of these tools in studying nanoscale ... -
New Transformations in the Transition-Metal Catalyzed Hydrofunctionalization of Alkynes
Hydrofunctionalization reactions are very useful transformations of unsaturated compounds and their development has been a major focus of research in the field of transition metal catalysis. These reactions allow the rapid ... -
Next-Generation Nanospectroscopy: Analytical and Numerical Models of New Developments in Electron Beam and Scanning Probe Experiments
The research field of nanophotonics, which aims to understand the propagation of light at the nanoscale and design novel optically-active materials, has risen to prominence since the discovery of the surface plasmon in ... -
NMR characterization guides the design of beta hairpins and sheets while providing insights into folding cooperativity and dynamics
(2006)Peptides populating the beta hairpin and sheet folding motifs commonly found in proteins have been designed using peptide design criteria and these sequences have been characterized with NMR spectroscopy. The use of chemical ... -
NMR Studies of Polypeptide Structuring and Aggregation
(2013-11-14)The importance of studying polypeptide structuring and folding mechanisms lies in the damage caused by misfolding proteins in the human body. The misfolding of proteins can lead to the off-pathway formation of aggreagates ... -
Nonlinear optical microscopy for tissue imaging and analysis in anatomic pathology
Stimulated Raman Scattering (SRS) microscopy provides chemical information for imaged tissue at submicron resolution. In the experiments described, I combine SRS with other non-linear microscopies, including second harmonic ...