Browsing Chemistry by Title
Now showing items 343-362 of 453
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Quantitative Analysis of Tyrosine Kinase Inhibitors Uptake in Cancer Cells Using Stimulated Raman Scattering Microscopy
Multidrug resistance remains a challenging problem in anti-cancer treatment. Transporters that regulate drug uptake and excretion are widely known to be the cause of multidrug resistance in cancer cells. Tyrosine kinase ... -
Quantitative kinetic analyses of adsorption and desorption processes at the liquid-solid interface with surface plasmon resonance
(1999)Surface Plasmon Resonance (SPR) spectroscopy is one of the few techniques that can directly detect adsorption onto a surface immersed in liquid with high time resolution and sensitivity to <5% of a monolayer. By modifying ... -
Quantum Cutting via Broadband Sensitization in Ytterbium-Doped Lead Halide Perovskites
The trivalent lanthanide (Ln3+) family has long been utilized for optical applications such as in lasing materials, lighting, and fiber optics. Their electronic structure is dominated by coulombic interactions and ... -
Reactive and soft landing of polyatomic gas-phase ions on plasma-treated metal surfaces
(2006)Non-destructive physical isolation of ions from the gas phase with preservation of their structure is referred to as ion soft landing. The presented dissertation describes in-situ plasma oxidized dry metal surfaces as novel ... -
Reactivity and Thermochemistry of First-Row Transition Metal Complexes with Stable Organic Radicals
Reactions involving transition metals and organic free radicals are critically important in a variety of chemical and biological processes. Because of their prevalence, there is a fundamental interest in better understanding ... -
Regenerating the sampling interface of modular chemical sensing systems
(2002)This dissertation describes modular chemical sensing systems (MCSS) and how the sampling interfaces of these systems can be regenerated. By regenerating the sampling interface, the reproducibility of the sensing system's ... -
Regio and diastereoselective synthesis of allylic amine through hydrocupration of terminal alkynes
Allylic amines play a crucial role in organic synthesis, owing to their versatility and unique chemical reactivity resulting from the allylic double bond. The significance of them is further evident in their incorporation ... -
Relating phase separation and thickness mismatch in model lipid membranes.
Membrane lipids can spontaneously undergo a process called phase separation wherein they organize into domains with different compositions. Phase separation has been proposed as a mechanism in the formation of heterogeneous ... -
Reversibly Reconfigurable Plasmonic Nanomaterials
University of Washington Abstract Reversibly Reconfigurable Plasmonic Nanomaterials Soumyadyuti Samai Chair of the Supervisory Committee: Professor David S. Ginger Department of Chemistry Plasmonic nanoparticles have been ... -
Room temperature methods of direct arylation for conjugated polymer and small molecule synthesis
Direct arylation polymerization (DArP) offers numerous benefits over classical methods of crosscouplingpolymerization, although improvements are still warranted to increase simplicity and reduce cost. Room temperature ... -
Scratching the Surface of Colloidal InP Nanoparticles: Tuning the Physical and Electronic Structure through Surface Chemistry
The structural and compositional variety of materials afforded by nanocrystal synthetic chemistry has established a foundation for developing high quality and tailored materials for a broad spectrum of applications, including ... -
Selective Bivalent Reagents for the Study of Protein Kinases
Protein kinases are involved in the regulation of many intracellular processes. Misregulation of these enzymes has been implicated in a variety of diseases making protein kinases viable drug targets. Despite this interest ... -
Semisynthesis of Ubiquitinated Histone H2B via Native Chemical Ligation
The ubiquitylation of histone H2B at Lys (K) 120 is known to be associated with methylation of H3K4 and H3K79, transcription elongation, and DNA repair. Mechanistic studies of interactions between H2BK120ub and other ... -
Sensitive and High-throughput Detection, Separation and Analysis of Circulating Tumor Cells
(2013-07-25)This dissertation describes novel methods to detect, separate and analyze circulating tumor cells (CTCs) from peripheral blood, with a high sensitivity and throughput. The ensemble-decision aliquot ranking (eDAR) platform ... -
Sequential injection analysis for the investigation of biomolecular interactions
(2000)This thesis presents the application of Flow and Sequential Injection technologies to problems of biomolecular interaction analysis. Both biochemical and biological systems are addressed.The biochemical application involved ... -
Simple Yet Versatile Fluorescent Labeling Methods for Advanced Microscopy Techniques
Advanced microscopy techniques have undergone rapid development in recent years and now enable the comprehensive 3-dimensional analysis of intact biological specimens over a wide range of length scales. Despite these ... -
Single-Cell Molecular Profiling of Nucleic Acids in the Microfluidic Self-Digitization Chip
In the last four decades, advancements in technologies to copy, measure, and manipulate DNA and RNA in situ have enabled new methods for research and diagnosis of disease. As a subset of these methods, novel microfluidic ... -
Single-Molecule Fluorescence Imaging of the Electrochemical Interface
In this dissertation, I firstly aim to use a solvatochromic dye, Nile red, to probe the dynamics of translocating oil emulsions through a nanopore, as well as to probe the hydrophobicity of bubble surface. Chapter 2 presents ... -
Single-Molecule Studies for the Characterization of Synaptic Vesicles
(2013-04-17)Synaptic vesicles are subcellular organelles that are found in the synaptic bouton and are responsible for the propagation of signals between neurons. Synaptic vesicles undergo a fast and tightly regulated cycle in which ... -
Small Molecule Activation Studies Involving Thiolate-Ligated Manganese(II) Complexes and Biologically-Relevant Oxidants
(2013-04-17)This dissertation focuses upon the synthesis, characterization, and reactivity of thiolate-ligated manganese complexes. Chapter 1 provides a brief introduction to the importance of manganese ions in biology, as well as the ...