Browsing Chemistry by Title
Now showing items 129-148 of 463
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Development of Newborn Screening Methods for Mucopolysaccharidosis III type A and type B in Dried Blood Spot using Tandem Mass Spectrometry
Chapter I. Development of Newborn Screening Method for Mucopolysaccharidosis III Type A in Dried Blood Spot using Tandem Mass Spectrometry Mucopolysaccharidosis III type A (MPS III A) is an autosomal recessive inherited ... -
Development of Novel Direct Arylation Methodology for the Synthesis of Conjugated Polymers
Conjugated polymers (CP) represent an important class of materials in the field of organic electronics. From the seminal Nobel prize-winning studies on the semiconducting properties of polyacetylene in the 1970s, the ... -
Development of Organic Photoredox-Mediated Ring-Opening Metathesis Polymerization through Expanded Functionalities of Initiators and Monomers
Ring-opening metathesis polymerization (ROMP), which is derived from transition-metal-based olefin metathesis, has evolved into one of the most prevalent technologies for making functional polymeric materials. Due to the ... -
Development of Palladium and Hypervalent Iodine(III) Catalyzed Alkene Difunctionalization Reactions; Hydroamination, Carboamination, Aminofluorination & Diamination
(2014-04-30)The investigation and development of synthetic methodologies for direct alkene difunctionalization is described. The utility of these processes is demonstrated by the synthesis of a number of functionalized nitrogen-containing ... -
Development of Practical Synthetic Tools Using Copper and Gold Catalysis
(2014-02-24)The use of transition metal catalysis in the synthesis of complex organic molecules has dramatically expanded the role of synthetic chemistry across a broad spectrum of applications including drug discovery, chemical ... -
Development of sirtuin and calmodulin-dependent protein kinase inhibitors as anti-cancer therapeutics
(2006)Small molecule inhibitors of the human sirtuins and calmodulin-dependent protein kinases have shown promising anti-cancer activity in cell-based screens and animal models. We have synthesized analogues of these compounds, ... -
Development of theory, instrumentation, and chemometric data analysis tools for comprehensive two- and three-dimensional gas chromatography
Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GCÃ GC-TOFMS) is now recognized as a powerful analytical platform for the separation and analysis of complex mixtures containing ... -
Development of Ultra-Fast Modulation for Application in Multi-Dimensional Gas Chromatography
A combination of four instrumental systems and one chemometric method are presented that improves the efficiency, resolving power (i.e. peak capacity/ peak capacity production), and lessens the typical time of multi-dimensional ... -
Dicationic dihydrogen complexes of osmium and ruthenium
(1997)The dicationic complexes $\rm\lbrack Os(H\sb2)(PR\sb3)\sb2(bpy)(CO)\rbrack\sp{2+}\ (PR\sb3=PPh\sb3,\ PMePh\sb2),\ \lbrack Os(H\sb2)(PPh\sb3)\sb2(phen)(CO)\rbrack\sp{2+},\ \lbrack Ru(H\sb2)(PPh\sb3)\sb2(bpy)(CO)\rbrack\sp{2+},\ ... -
Dioxygen Activation by Thiolate Ligated Complexes with Tunable pi-Acceptor N-Heterocyclic Ligands
Dioxygen reduction and water oxidation are critical processes for aerobic life. Developing a better understanding of O-O bond activation and formation mechanisms mediated by metalloenzymes involving first-row transition ... -
Direct Solution Synthesis of Transition Metal Borides
Recent years have seen an increase in the study of metal borides due to their multifaceted applications, ranging from abrasive materials to superconductors. This variety in function emerges from the distinctive bonding ... -
Discovery based yeast metabolomic analysis using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry and chemometrics
(2007)Comprehensive two-dimensional (2D) separations are highly beneficial in the characterization of complex samples. The research presented in this dissertation involves the analysis of the small polar molecules comprising the ... -
Dissecting Mechanisms of Antimalarials using CRISPR/Cas9 Editing in Plasmodium falciparum
Malaria, caused by Plasmodium infections, continues to be a global disease of public health importance with 300 million annual cases and about 500,000 deaths. Continual emergence of resistance to commonly used antimalarials ... -
Dissection of spatiotemporal intracellular signaling using engineered chemical and genetic tools
Cellular signaling proteins are responsible for transmitting intracellular signals and enacting the appropriate response to received stimuli. These messages are propagated through networks that rely on allosteric regulation, ... -
Divergent Allosteric Control of IRE1alpha endoribonuclease using small molecule kinase inhibitors
When unfolded proteins get accumulated in the endoplasmic reticulum (ER), signaling pathways called the unfolded protein response (UPR) get turned on in the cell. However under conditions of chronic ER stress, the cell ... -
DNA studies: a novel structural transition, relaxation of secondary structure by TOPO I, and resolution of a PCR problem
(2006)Both theory and experiments were employed previously to investigate the effects of small neutral osmolytes on the twist energy parameter ( ET) and average intrinsic twist (l 0) of p30delta DNA (4932 bp). The results for ... -
Dyeing crystals: 19th century phenomenology to 21st century technology
(2007)The linear dichroism of organic light-absorbing molecules (dyes) contained within varied solid matrices are analyzed. Hosts of increasing disorder from single crystals, to organized polycrystalline formations, to polymers ... -
Dynamics and structures of linear and supercoiled DNAs
(1989)A normal mode theory is developed for the Brownian dynamics of weakly bending rods with preaveraged hydrodynamic interactions. An expression is given for the mean squared angular displacement $$ of the $m\sp{th}$ bond-vector ... -
Effects of Ligand-Constraints on the Reactivity of Biomimetic Thiolate-Ligated Transition Metal Complexes
The addition of steric constraints to thiolate-ligated transition metal complexes was explored herein, with particular focus on the addition of a tertiary amine to the backbone to form complexes [FeII(S2Me2N2NMe(Pr,Pr))] ... -
Electro-Optic Material Design Criteria Derived from Condensed Matter Simulations Using the Level-of-Detail Coarse-Graining Approach
Electro-optic materials enable a wide variety of photonics applications such as micro-scale optical sensors, terahertz spectroscopy, photonic computing, quantum key distribution, and high speed data transmission for computing ...