Browsing Chemistry by Title
Now showing items 43-62 of 463
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The biosynthesis of manumycin type metabolites
(2000)The biosynthesis of manumycin type metabolites has been thoroughly studied, mainly with the asukamycin producer, Streptomyces nodosus. A complete biosynthetic pathway has been elucidated from two approaches: (i) synthesizing ... -
The biosynthesis of the thiopeptide antibiotic thiostrepton
(1999)Thiostrepton is a sulfur rich, highly modified peptide antibiotic produced by the soil bacteria Streptomyces laurentii, Streptomyces azureus , and Streptomyces hawaiiensis. It is a member of the structurally similar ... -
Breaking symmetry in time-dependent electronic structure theory to describe spectroscopic properties of non-collinear and chiral molecules.
Time-dependent electronic structure theory has the power to predict and probe the ways electron dynamics leads to useful phenomena and spectroscopic data. Here we report several advances and extensions of broken-symmetry ... -
A Broadband Optical Ring Resonator for Absorption and Refractive Index Detection
(2013-07-23)Optical ring resonators have been studied in recent years as chemical sensors. Conventionally, these devices are operated by means of tracking a single resonance wavelength through use of a finely tunable laser source. ... -
C-H Functionalisation of Alkenes via Organoselenium Catalysis
C-H functionalisation of simple, abundant, and inexpensive alkenes is a privileged strategy for rapid construction of complex molecular architectures in organic synthesis and industrial chemical processes. Although this ... -
Capillary Flow Characterization and Application in Saliva Sampling
The use of microfluidic channels is becoming increasingly prevalent in the biomedical field. Assuch, the characterization of capillary flow is vital to facilitate functional adaptations. The impact of progressive converging ... -
Caps - Turns - Loops: Designing Better β-Hairpins
As protein engineering promises advances in almost every field of science and medicine, a greater understanding of the protein folding problem is necessary to make these innovations a reality. This thesis examines one ... -
Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway and Toward Discovery of Inhibitors of Human Group III Secreted Phospholipase A2 and Lessons Learned from In Vivo Mouse Studies of Secreted Phospholipase A2 Clearance from Extra-Cellular Medium by the M-type Receptor
Chapter I. Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway The serine hydrolase inhibitors Pyrrophenone and KT195 were found to inhibit cell death induced by A23187 and H2O2 in mouse lung ... -
Cationic dihydrogen complexes of rhenium with isonitrile coligands
(1996)The syntheses, characterizations, and reactivities of the following new complexes are reported: Re(CNtBu)$\rm\sb3(PR\sb3)\sb2$X(R = Cy, X = H, F, Cl, Br, I; R = Ph, X = H, Cl), (Re(CNtBu)$\rm\sb3(PR\sb3)\sb2L\rbrack\sp+$ ... -
CE-microreactor-CE-MS-MS for protein analysis
(2006)Capillary electrophoresis-mass spectrometry (CE-MS) provides a powerful system that combines the speed and automation capabilities of CE with the detection and identification capabilities of MS. Integrating on-line enzymatic ... -
Cells Incognito: Microfluidic Tools for Detecting and Isolating Cancer Cells
Cancer continues to be one of the leading causes of death around the world. The disease is characterized by uncontrolled cell growth and is spread throughout the body by the dissemination of cancer cells into circulation. ... -
Characterization and Exploitation of Bidirectional Allosteric Coupling in Multi-Domain Tyrosine Kinases using Conformation-Selective ATP-Competitive Inhibitors
Protein kinases are a large family of enzymes that play integral roles in cell signaling networks and are thus critical for effecting appropriate cellular responses to environmental stimuli. Much of kinase biological ... -
Characterization of the Structure and Dynamics of Biomimetic Peptides by Solid-State NMR
Diatoms and sponges use proteins, long chain polyamines, and other biomolecules to assemble silica structures of controlled morphology. Investigated here are biosilicification peptides. Under mild conditions, these peptides ... -
Characterization of the Structures of Small Peptides and their Interactions with Inorganic Minerals
Proteins mediate the nucleation and growth of many biominerals, yet the specifics of these protein-mineral interactions are often poorly understood. The focus of this dissertation is to better understand these interactions ... -
Characterization of Trp-Cage and Its Circular Permutation
The relationship between sequence, the folded structure, and the folding pathway by which that structure is reached presents a topic of tremendous importance in the understanding of proteins. However, the study of most ... -
Chemical Approaches to Investigate the Biochemical Crosstalk Between Histone Sumoylation, Methylation and Acetylation
Histone post-translational modifications (PTM) within chromatin control many DNA-templated cellular processes, from DNA damage repair pathways to gene transcription. In order to understand the influence of PTM on these ... -
Chemical Approaches to Study the Effect of Histone Post-translational Modifications
Genetic material is stored in a massive nucleoprotein complex called Chromatin. The basic unit of Chromatin is the Nucleosome Core Particle or NCP, made up of 147 bp DNA wound around a core of histone protein octamer ... -
Chemical Proteomic Tools for Studying Protein Kinase Active Sites
(2013-02-25)Protein kinases constitute one of the largest protein families in humans. These enzymes catalyze phosphorylation of serine, threonine or tyrosine residues in their protein substrates. As protein kinases regulate most signal ... -
Chemical strategies for investigation of deubiquitinases
Regulation of protein structure and function by post-translational modification is a key mechanism in cellular homeostasis. Among known modifications the small protein ubiquitin is unique in the breadth of functions it ... -
Chemical Strategies to Enrich Malarial Proteins from Wheat Lysate
(2012-09-13)Malaria is a major public health burden and developing the next generation of anti-malarials is vital to control the spread of disease. Protein arrays, which can investigate binding of many proteins to various probes ...