Browsing Chemistry by Subject "Mass Spectrometry"
Now showing items 1-8 of 8
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Development of chemometric methodologies for supervised class-based discovery experiments using GCÃ GC-TOFMS: application to aerospace fuel analysis
Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry detection (GCÃ GC-TOFMS) is a prominent instrumental technique which produces information rich datasets for the analysis of complex ... -
Development of Instrumental and Computational Methods for Accessing Information in Multi-Dimensional Gas Chromatography with Mass Spectrometry
Three instrumental and computational methods are demonstrated in an endeavor to create novel techniques to extract information from the troves of data generated by multi-dimensional gas chromatography with mass spectrometry. ... -
Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-Phase Structures of Protein and Protein Complex Ions
This dissertation reports the development of new ion mobility mass spectrometry (IM-MS) instrumentation to analyze protein and protein complex ions. IM-MS is a gas-phase analytical technique that separate ions based on ... -
Investigating the Relationship Between the Gas-Phase Structures of Protein Ions and Their Charge States
This dissertation explores the utility of cation-to-anion proton transfer reactions (CAPTR) in native mass spectrometry, and investigates the relationship between the charge state (z) and collision cross section (Ω) of ... -
New Analytical Tools for Native Mass Spectrometry and Ion Mobility Mass Spectrometry Analysis of Intact Proteins
Native mass spectrometry (MS) is a structural biology tool that probes proteins and protein complexes in the gas phase. In native MS, electrospray ionization (ESI) of protein samples are prepared in nondenaturing conditions ... -
New Ion Mobility-Mass Spectrometry Tools to Characterize and Differentiate Similar Proteins
This dissertation describes new ion mobility-mass spectrometry (IM-MS) approaches for the characterization and differentiation of similar proteins, namely antibodies. Antibodies form the basis of a growing class of ... -
Structural Elucidation of Gas-Phase Peptide Ions by Tandem Mass Spectrometry and Molecular Dynamics Simulations
The invention of the mass spectrometer has enabled scientists to discover numerous fascinating reactive gas-phase chemical species such as peptide cation radicals. The generation of these radicals can be accomplished via ... -
Working Toward a Long-Term, Real-Time Measurement Network for Atmospheric Aerosol Sources
Aerosols have a significant impact on both human health and the Earth’s climate. Due to their complexity and variety, however, relatively little is known about them. ASCENT is a new aerosol measuring network that aims to ...