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Electron paramagnetic resonance spectroscopy of spin-labeled RNA: an emerging tool for the elucidation of RNA structure and dynamics
Electron paramagnetic resonance (EPR) spectroscopy was applied to the study of RNA structure and dynamics. A general and efficient method for the site-specific incorporation of nitroxide spin-labels into internal sites of RNA is described. The spin labeling reagent 4-isocyanato TEMPO reacts with 2'-amino modified RNA in >90% ...