Now showing items 1-1 of 1
Pharmacological Modulation and Functional Characterization of the Protein Kinase-Endoribonuclease IRE1α
Faithful folding of proteins in the endoplasmic reticulum (ER) is essential for cell survival and proper cellular function. Understandably, unfolded or misfolded proteins contribute to a myriad of human diseases. Numerous cellular perturbations can overwhelm the homeostatic capacity of the ER, causing the accumulation of ...