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Chemical Approaches to Study the Effect of Histone Post-translational Modifications
Genetic material is stored in a massive nucleoprotein complex called Chromatin. The basic unit of Chromatin is the Nucleosome Core Particle or NCP, made up of 147 bp DNA wound around a core of histone protein octamer comprising two of each histone H2A, H2B, H3 and H4. The positively charged tails of the histones extend outwards ...