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Solution-state conformational studies of endothelin analogs
Endothelin-1 (ET-1), a 21-residue peptide hormone containing two disulfide bridges, is the most potent endogenous mammalian vasoconstrictor known. Endothelin binds, with high specificity, to a G-protein coupled transmembrane receptor, designated ETA. Although a consensus NMR structure of the bicyclic core has been reached, ...