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The biosynthesis of the thiopeptide antibiotic thiostrepton
Thiostrepton is a sulfur rich, highly modified peptide antibiotic produced by the soil bacteria Streptomyces laurentii, Streptomyces azureus , and Streptomyces hawaiiensis. It is a member of the structurally similar thiopeptide antibiotic family. Thiostrepton has been found to show strong antibiotic activity towards Gram-positive ...