The packaging of DNA within the nucleus of a eukaryotic organism is facilitated by the formation of a nucleoprotein complex known as chromatin. There are various DNA binding proteins that play an important part in this process, but the four core histone proteins namely, H2A, H2B, H3 and H4 are essential for forming the ...

Eukaryotic DNA is packaged into chromatin, which consists of a fundamental repeating unit, the nucleosome, and its associated proteins. Nucleosomes are made up of histone protein octamers, containing two each of histones H2A, H2B, H3, and H4, around which ~147 bp of DNA is wound. The tails of histones are disordered and extend ...