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Divergent Allosteric Control of IRE1alpha endoribonuclease using small molecule kinase inhibitors
When unfolded proteins get accumulated in the endoplasmic reticulum (ER), signaling pathways called the unfolded protein response (UPR) get turned on in the cell. However under conditions of chronic ER stress, the cell undergoes apoptosis. Key events of this "Terminal UPR" are controlled by IRE1α - an ER bifunctional ...